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Autoimmune and Hypersplenic Cytopenias

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Chronic Lymphocytic Leukemia

Part of the book series: Contemporary Hematology ((CH))

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Abstract

Perhaps the most important observation concerning chronic lymphocytic leukemia (CLL) made in the 20th century was the assertion by Rai in America (1) and Binet in France (2) that anemia or thrombocytopenia carries a grave prognosis. Although neither of these authors’ scoring system demands it, it is axiomatic that for this to be true, the cytopenia must be the consequence of bone marrow suppression. As it happens, there are two other important reasons for cytopenias in CLL: autoimmunity and hypersplenism. Neither of these causes necessarily carries the same dire consequences.

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Authors
  1. Terry Hamblin MB, DM
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  1. Section of Hematology/Oncology, Veterans Affairs Medical Center, Augusta, GA, USA

    Guy B. Faguet MD

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Hamblin, T. (2004). Autoimmune and Hypersplenic Cytopenias. In: Faguet, G.B. (eds) Chronic Lymphocytic Leukemia. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-412-2_20

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  • DOI: https://doi.org/10.1007/978-1-59259-412-2_20

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