Parkinson’s Disease: Etiologic Considerations

  • Peter A. LeWitt
Part of the Current Clinical Practice book series (CCP)


Parkinson’ s disease (PD) is associated with distinctive and highly localized pathologic changes in the brain. Degeneration of substantia nigra pars compacta neurons within the midbrain is pronounced in patients with PD. These dopaminergic neurons project to the striatum, and loss of striatal dopamine is responsible for most of the motor deficits of PD.


Substantia Nigra Multiple System Atrophy Lewy Body Essential Tremor Striatal Dopamine 
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© Springer Science+Business Media New York 2000

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  • Peter A. LeWitt

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