Parkinson’s Disease: Etiologic Considerations
Parkinson’ s disease (PD) is associated with distinctive and highly localized pathologic changes in the brain. Degeneration of substantia nigra pars compacta neurons within the midbrain is pronounced in patients with PD. These dopaminergic neurons project to the striatum, and loss of striatal dopamine is responsible for most of the motor deficits of PD.
KeywordsSubstantia Nigra Multiple System Atrophy Lewy Body Essential Tremor Striatal Dopamine
Unable to display preview. Download preview PDF.
- Golbe LI. The epidemiology of Parkinson’s disease, in Parkinson’s Disease: The Treatment Options ( LeWitt PA, Oertel WH eds), Martin Dunitz Publishers, London, 1999, pp. 63–77.Google Scholar
- McGeer EG, McGeer PL. Neurodegeneration and the immune system, in Neurodegenerative Diseases (Caine DB ed), W. B. Saunders Company, Philadelphia, 1994, pp. 277–300.Google Scholar
- Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL. Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 1997; 276: 2045–2047.PubMedCrossRefGoogle Scholar