Abstract
Restless legs syndrome (RLS) is a disorder that was first described by Thomas Willis in 1672. Much later, authors referred to this condition variably as “anxietas tibiarum” and “leg jitters.” On the basis of a large series of patients, Ekbom, a Swedish physician, coined the term “restless legs” in 1944 and gave the first full clinical description of RLS. Thus, RLS is sometimes referred to as “Ekbom’s syndrome.” He found that about 5% of normal subjects report occasional crawling sensations in their legs and that familial clustering occurs in some cases. He also described secondary forms due to anemia or pregnancy. Ekbom’s son later described instances of RLS after gastric surgery, presumably due to iron deficiency.
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Selected Reading
Allen RP, Earley CJ. Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep 1996; 19: 205–213.
Allen RP, Kaplan PW, Buchholz DW, Earley CJ, Walters JK. Double-blinded, placebo controlled comparison of high dose propoxyphene and moderate dose carbidopa/levodopa for treatment of periodic limb movements in sleep (abstract). Sleep Res 1992; 21: 166.
Becker PM, Jamieson AO, Brown WD. Dopaminergic agents in restless legs syndrome and periodic limb movements of sleep: response and complications of extended treatment in 49 cases. Sleep 1993; 16: 713–716.
Bucher SF, Seelos KC, Oertel WH, Reiser M, Trenkwalder C. Cerebral generators involved in the pathogenesis of the restless legs syndrome. Ann Neurol 1997; 41: 639–645.
Earley CJ, Allen RP. Pergolide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients. Sleep 1996; 19: 801–810.
Evidente VGH, Adler CH. How to help patients with restless legs syndrome: discerning the indescribable and relaxing the restless. Postgrad Med 1999; 105: 59–74.
Hening WA, Walters A, Kavey N, Gidro-Frank S, Cote L, Fahn S. Dyskinesias while awake and periodic movements in sleep in restless legs syndrome: treatment with opioids. Neurology 1986; 36: 1363–1366.
Iannaccone S, Zucconi M, Marchettini P, Ferini-Strambi L, Nemni R, Quattrini A, Palazzi S, Lacerenza M, Formaglio F, Smirne S. Evidence of peripheral axonal neuropathy in primary restless legs syndrome. Mov Disord 1995; 10: 2–9.
Krueger BR. Restless legs syndrome and periodic movements of sleep. Mayo Clin Proc 1990; 65: 999–1006. Montplaisir J, Godbout R, Boghen D, DeChamplain J, Young SN, Lapierre G. Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study. Neurology 1985; 35: 130–134.
O’Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing 1994; 23: 200–203.
O’Keeffe ST, Noel J, Lavan JN. Restless legs syndrome in the elderly. Postgrad Med J 1993; 69: 701–703. Ondo W, Jankovic J. Restless legs syndrome: clinicoetiologic correlates. Neurology 1996; 47: 1435–1441.
Poceta JS. Restless legs syndrome and nocturnal myoclonus, in Sleep Disorders: Diagnosis and Treatment ( Poceta JS, Mitler MM eds), Humana Press Inc., Totowa, 1998, pp. 75–93.
Rutkove SB, Matheson JK, Logigian EL. Restless legs syndrome in patients with polyneuropathy. Muscle Nerve 1996; 19: 670–672.
Silber MH. Restless legs syndrome. Mayo Clin Proc 1997; 72: 261–264.
Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord 1995; 10: 634–642.
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Evidente, V.G.H., Adler, C.H. (2000). Restless Legs Syndrome. In: Adler, C.H., Ahlskog, J.E. (eds) Parkinson’s Disease and Movement Disorders. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-410-8_30
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DOI: https://doi.org/10.1007/978-1-59259-410-8_30
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