What Is Parkinson’s Disease? Neuropathology, Neurochemistry, and Pathophysiology
Idiopathic parkinsonism, or Parkinson’ s disease (PD), is a neurodegenerative disorder of middle and late life with a well-defined morbid anatomy, a specific pattern of biochemical pathology, and an unknown cause. Its name immortalizes Dr. James Parkinson, the British physician whose classic 1817 monograph, Essay on the Shaking Palsy, is unrivaled as a lucid and timeless description of the cardinal symptoms and signs of what is now recognized as one of the most common neurologic disorders in the Western world.
KeywordsBasal Ganglion Multiple System Atrophy Idiopathic Parkinsonism Subthalamic Nucleus Progressive Supranuclear Palsy
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