What Is Parkinson’s Disease? Neuropathology, Neurochemistry, and Pathophysiology

  • Howard Hurtig
Part of the Current Clinical Practice book series (CCP)


Idiopathic parkinsonism, or Parkinson’ s disease (PD), is a neurodegenerative disorder of middle and late life with a well-defined morbid anatomy, a specific pattern of biochemical pathology, and an unknown cause. Its name immortalizes Dr. James Parkinson, the British physician whose classic 1817 monograph, Essay on the Shaking Palsy, is unrivaled as a lucid and timeless description of the cardinal symptoms and signs of what is now recognized as one of the most common neurologic disorders in the Western world.


Basal Ganglion Multiple System Atrophy Idiopathic Parkinsonism Subthalamic Nucleus Progressive Supranuclear Palsy 
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Selected Reading

  1. Gibb WRG, Lees AJ. Pathological clues to the cause of Parkinson’ s disease, in Movement Disorders(Marsden CD, Fahn S eds), 3rd ed, Butterworth-Heinemann, Oxford, 1994, pp. 147–166.Google Scholar
  2. Marsden CD. Neurophysiology, in Parkinson’s Disease( Stern GM ed), Johns Hopkins University Press, Baltimore, 1990, pp. 57–98.Google Scholar
  3. Marsden CD. The mysterious motor function of the basal ganglia: the Robert Wartenberg Lecture. Neurology 1982; 32: 514–539.PubMedCrossRefGoogle Scholar
  4. Stern MB. Contemporary approaches to the pharmacotherapeutic management of Parkinson’s disease: an overview. Neurology1997; 49 Suppl 1: S2 - S9.PubMedCrossRefGoogle Scholar
  5. Uhl GR. Hypothesis: the role of dopaminergic transporters in selective vulnerability of cells in Parkinson’s disease. Ann Neurol1998; 43: 555–560.PubMedCrossRefGoogle Scholar
  6. Wichmann T, DeLong MR. Physiology of the basal ganglia and pathophysiology of movement disorders of basal ganglia origin, in Movement Disorders: Neurologic Principles and Practice( Watts RL, Koller WC eds), McGraw-Hill, New York, 1997, pp. 87–97.Google Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Howard Hurtig

There are no affiliations available

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