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Immune System

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Combat Medicine

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Abstract

The golden hour—that precious 60-minute countdown to stabilize the wounds of soldiers, to save their lives and limbs—extends to days and weeks in field hospitals. After the battle of El Alamein, a surgeon wrote that severe wounds were often followed by illness (more or less serious, lasting for several days) in which many factors other than blood loss or its late effects operated (1). The precise nature of these factors has been a source of debate ever since. Most critically wounded soldiers die immediately from rupture of the heart or major blood vessels or massive neurologic trauma. Around 50% of severely injured trauma patients who survive their initial injuries will succumb days to weeks after injury because of abnormalities of the immune system and infection/septic complications leading to the systemic inflammatory response syndrome (SIRS) and multiple organ system failure (MOF) despite proper therapy. The development of MOF after trauma is associated with remote organ failure (ROF), the dysfunction of organs that were not affected by the injury.

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Authors
  1. Madhusoodana P. Nambiar PhD
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Editors and Affiliations

  1. Walter Reed Army Institute of Research, Silver Spring, MD, USA

    George C. Tsokos MD  & James L. Atkins MD  & 

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© 2003 Springer Science+Business Media New York

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Nambiar, M.P. (2003). Immune System. In: Tsokos, G.C., Atkins, J.L. (eds) Combat Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-407-8_5

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  • DOI: https://doi.org/10.1007/978-1-59259-407-8_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-337-4

  • Online ISBN: 978-1-59259-407-8

  • eBook Packages: Springer Book Archive

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