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The Use of Cytokine Knockout Mice in Neuroimmunology

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Cytokine Knockouts

Part of the book series: Contemporary Immunology ((CONTIM))

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Summary

In this chapter, we have attempted to provide a synopsis of current work being performed using cytokine knockout or transgenic animals in neuroimmunology research. This is a fast-growing area that is expanding dramatically as genetically modified animals for cytokines, their receptors, or signalling components become available. We have focused primarily on the best-known cytokines (IL-1, IL-6, TNF-α, IL-10 & IL-4) simply to highlight the contribution so far of this tool to research into cytokines and neuroimmunology. In addition and as a reflection of the growing areas of research using this technology, we were limited to focusing on the use of genetically modified animals in two areas, namely, fever as a model of infection and stroke following middle cerebral artery occlusion as an approach to study brain injury and inflammation.

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Authors
  1. Giamal N. Luheshi
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  2. Emmanuel Pinteaux
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  3. Hervé Boutin
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Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Giamila Fantuzzi PhD

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Luheshi, G.N., Pinteaux, E., Boutin, H. (2003). The Use of Cytokine Knockout Mice in Neuroimmunology. In: Fantuzzi, G. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-405-4_5

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  • DOI: https://doi.org/10.1007/978-1-59259-405-4_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-415-9

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