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Cytokine Knockouts pp 171–186Cite as

G-CSF, GM-CSF, and IL-3 Knockout Mice

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Part of the book series: Contemporary Immunology ((CONTIM))

Summary

Granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GMCSF), and interleukin-3 (IL-3) stimulate the proliferation, differentiation, and activation of multiple hematopoietic cells. G-CSF acts primarily on mature neutrophils and their precursors, and the ability of this cytokine to promote granulopoiesis in vivo underlies its clinical application in the setting of neutropenia. GM-CSF influences a broader range of cells, including neutrophils, eosinophils, macrophages, erythroid progenitors, megakaryocyte progenitors, and dendritic cells. These properties result in marked immunostimulation, and have led to clinical testing of the cytokine as a vaccine adjuvant. IL-3 augments the numbers and functions of hematopoietic progenitors, mast cells, basophils, neutrophils, macrophages, eosinophils, erythrocytes, megakaryocytes, and dendritic cells.

In this chapter we review the generation and characterization of mice deficient in each of these cytokines. These studies have delineated essential roles for the molecules in hematopoiesis, immunity, and pulmonary homeostasis.

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Authors
  1. Thomas Enzler
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  2. Glenn Dranoff
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  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Giamila Fantuzzi PhD

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Enzler, T., Dranoff, G. (2003). G-CSF, GM-CSF, and IL-3 Knockout Mice. In: Fantuzzi, G. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-405-4_10

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  • DOI: https://doi.org/10.1007/978-1-59259-405-4_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-415-9

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