Abstract
Polyglandular autoimmune syndrome (PGA) includes a complex mixture of endocrine and nonendocrine disorders. PGA is generally divided into type I and type II disorders (Table 1) [1,2].
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References
Eisenbarth GS, Verge CF. Immunoendocrinopathy syndromes. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Williams Textbook of Endocrinology, 9th edit. Philadelphia: WB Saunders, 1998: 1651–1662.
Orth DN, Kovacs WJ. The adrenal cortex. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Williams Textbook of Endocrinology, 9th edit. Philadelphia: WB Saunders, 1998: 517–664.
Ahonen P, Myllarniemi S, Sipila I, Perheentupa J. Clinical variation of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med 1990; 322: 1829–1836.
Neufeld M, Maclaren NK, Blizzard RM. Two types of autoimmune Addison’s disease associated with different polyglandular autoimmune (PGA) syndromes. Medicine (Baltimore) 1981; 60: 355–362.
Blizzard RM, Chee D, Davis W. The incidence of parathyroid and other antibodies in the sera of patients with idiopathic hypoparathyroidism. Clin Exp Immunol 1966; 1: 119–128.
Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K. Identification by molecular cloning of an autoantigen associated with Addison’s disease as steroid 17 alpha-hydroxylase. Lancet 1992; 339: 770–773.
Uibo R, Aavik E, Peterson P, et al. Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison’s disease. J Clin Endocrinol Metab 1994; 78: 323–328.
Tuomi T, Bjorses P, Falorni A, et al. Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 1996; 81: 1488–1494.
Ahonen P. Autoimmune polyendocrinopathy–candidosis–ectodermal dystrophy (APECED): autosomal recessive inheritance. Clin Genet 1985; 27: 535–542.
Zlotogora J, Shapiro MS. Polyglandular autoimmune syndrome type I among Iranian Jews. J Med Genet 1992; 29: 824–826.
Kumar PG, Laloraya M, She JX. Population genetics and functions of the autoimmune regulator (AIRE). Endocrinol Metab Clin North Am 2002; 2: 321–338.
Chen QY, Lan MS, She JX, Maclaren NK. The gene responsible for autoimmune polyglandular syndrome type 1 maps to chromosome 21q22.3 in US patients. J Autoimmun 1998; 11: 177–183.
Vogel A, Strassburg CP, Obermayer-Straub P, Brabant G, Manns MP. The genetic background of autoimmune polyendocrinopathy– candidiasis–ectodermal dystrophy and its autoimmune disease components. J Mol Med 2002; 80: 201–211.
Meyer G, Donner H, Herwig J, Bohles H, Usadel KH, Badenhoop K. Screening for an AIRE-1 mutation in patients with Addison’s disease, type 1 diabetes, Graves’ disease and Hashimoto’s thyroiditis as well as in APECED syndrome. Clin Endocrinol (Oxf) 2001; 54: 335–228.
Mora S, Weber G, Barera G, et al. Effect of gluten-free diet on bone mineral content in growing patients with celiac disease. Am J Clin Nutr 1993; 57: 224–228.
Baisch JM, Weeks T, Giles R, Hoover M, Stastny P, Capra JD. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med 1990; 332: 1836–1841.
Santamaria P, Barbosa JJ, Lindstrom AL, Lemke TA, Goetz FC, Rich SS. HLA-DQB 1-associated susceptibility that distinguishes Hashimoto’s thyroiditis from Graves’ disease in type I diabetic patients. J Clin Endocrinol Metab 1994; 78: 878–883.
McDermid HE, Morrow BE. Genomic disorders on 22q1 1. Am J Hum Genet 2002; 70: 1077–1088.
Iascone MR, Vittorini S, Sacchelli M, Spadoni I, Simi P, Giusti S. Molecular characterization of 22q11 deletion in a three-genera-tion family with maternal transmission. Am J Med Genet 2002; 108: 319–321.
Rabinowe SL, Rubin IL, George KL, Adri MN, Eisenbarth GS. Trisomy 21 (Down’s syndrome): autoimmunity, aging and monoclonal antibody-deifned T-cell abnormalities. J Autoimmun 1989; 2: 25–30.
Imawari M, Akatsuka N, Ishibashi M, Beppu H, Suzuki H. Syndrome of plasma cell dyscrasia, polyneuropathy, and endocrine disturbances. Report of a case. Ann Intern Med 1974; 81: 490–493.
Amiel LL, Machover D, Droz JP. Dyscrasie plasmocytaire avec arteriopathie, polyneuropathie, syndrome endocrinien. Ann Med Intern 1975; 745–749.
Iwashita H, Ohnishi A, Asada M, Kanazawa Y, Kuroiwa Y. Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma. Neurology 1977; 27: 675–681.
Menser MA, Forrest JM, Bransby RD. Rubella infection and diabetes mellitus. Lancet 1978; 1: 57–60.
Rabinowe SL, George KL, Loughlin R, Soeldner JS, Eisenbarth GS. Congenital rubella. Monoclonal antibody-deifned T cell abnormalities in young adults. Am J Med 1986; 81: 779–782.
Kahn CR, Flier JS, Bar RS, et al. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med 1976; 294: 739–745.
Flier JS, Bar RS, Muggeo M, Kahn CR, Roth J, Gorden P. The evolving clinical course of patients with insulin receptor autoantibodies: spontaneous remission or receptor proliferation with hypoglycemia. J Clin Endocrinol Metab 1978; 47: 985–995.
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Lloyd, R.V. (2004). Polyglandular Autoimmune Syndromes. In: Lloyd, R.V. (eds) Endocrine Pathology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-403-0_20
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DOI: https://doi.org/10.1007/978-1-59259-403-0_20
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