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Cost-Effective Care in the Management of Conduction Disease and Arrhythmias

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Cardiovascular Health Care Economics

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

In the treatment of arrhythmias and disease of the conduction system, physicians have an ever-growing menu of tests, drugs, and devices from which to choose. How best to use this diagnostic and therapeutic armamentarium in patient care has become an area of active study, and clinical trials to establish efficacy are now quite common. As should be the case, the major focus of these studies has been on clinical outcomes. However, as in other areas of medicine that have seen rapid growth in available technology and expanding indications for its use, there has been a growing concern about the impact of practice choices on the costs of care and whether, from a societal view, the costs are acceptable. Consequently, there has been literature emerging on the cost-effectiveness (CE) of device use and treatment strategies in the management of patients with conduction disease and arrhythmias. In this chapter, we review the current literature on the cost-effective use of pacemakers and implantable cardioverter defibrillators (ICDs), as well as what is known about cost-effective treatment strategies for the management of supraventricular arrhythmias, including radiofrequency ablation and the whole range of options for managing the most common of arrhythmias, atrial fibrillation.

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References

  1. Thalen HJT, Van den Bert JW, Van der Heide JN, Nieveen J. The Artificial Cardiac Pacemaker. Assen, Charles C. Thomas, The Netherlands, 1969 pp. 313–331.

    Google Scholar 

  2. Bernstein AD, Parsonnet V. Survey of cardiac pacing in the United States in 1989. Am J Cardiol 1992; 69: 331–338.

    Article  PubMed  CAS  Google Scholar 

  3. Goldman L, Fraser JD, Morgan CD. Survey of cardiac pacing in Canada. Can J Cardiol 1991; 7: 391–398.

    PubMed  CAS  Google Scholar 

  4. Lamas GA, Estes NMI, Schneller S, et al. Does dual chamber or atrial pacing prevent atrial fibrillation? The need for a randomized controlled trial. PACE 1992; 15: 1109–1113.

    Article  PubMed  CAS  Google Scholar 

  5. Pearson A, Janosik DL, Redd RM, et al. Hemodynamic benefit of atrioventricular synchrony: prediction from baseline doppler-echocardiographic variables. J Am Coll Cardiol 1989; 13: 1613–1620.

    Article  PubMed  CAS  Google Scholar 

  6. Andersen HR, Nielsen JC, Thomsen PE, et al. Long-term follow-up of patients from a randomizsed trial of atrial versus ventricular pacing for sick-sinus syndrome. Lancet 1997; 350: 1210–1216.

    Article  PubMed  CAS  Google Scholar 

  7. Sgarbossa EB, Pinski SL, Castle LW, et al. Incidence and predictors of loss of pacing in the atrium in patients with sick sinus syndrome. Pacing Clin Electrophysiol 1992; 15: 2050–2054.

    Article  PubMed  CAS  Google Scholar 

  8. Sutton R, Kenny RA. The natural history of sick sinus syndrome. Pacing Clin Electrophysiol 1986; 9: 1110–1114.

    Article  PubMed  CAS  Google Scholar 

  9. Ellenbogen KA, Gilligan DM, Wood MA, et al. The pacemaker syndrome: a matter of definition. Am J Cardiol 1997: 1226–1228.

    Google Scholar 

  10. Nishimura RA, Gersh BJ, Holmes DRJ, et al. Outcomes of dual-chamber pacing for the pacemaker syndrome. Mayo Clin Proc 1983; 58: 452–456.

    PubMed  CAS  Google Scholar 

  11. Schuller H, Brandt J. The pacemaker syndrome: Old and new causes. Clin Cardiol 1991; 14: 336–340.

    Article  PubMed  CAS  Google Scholar 

  12. Paxinos G, Katritsis D, Kakouros S, et al. Long-term effect of VVI pacing on atrial and ventricular function in patients with sick sinus syndrome. Pacing Clin Electrophysiol 1998; 21: 728–734.

    Article  PubMed  CAS  Google Scholar 

  13. Roseqvist M, Brandt J, Schuller H. Long-term pacing in sinus node disease: effects of stimulation mode on caradiovascular morbidity and mortality. Am Heart J 1988; 116: 16–22.

    Article  Google Scholar 

  14. Lamas GA, Pashos CL, Normand SLT, et al. Permanent pacemaker selection and subsequent survival in elderly Medicare pacemaker recipients. Circulation 1995; 91: 1063–1069.

    Article  PubMed  CAS  Google Scholar 

  15. Lamas GA, Orav EJ, Stambler BS, et al. Quality of life and clinical outcomes in elderly patients treated with ventricular pacing as compared with dual chamber pacing. N Engl J Med 1998; 338: 1097–1104.

    Article  PubMed  CAS  Google Scholar 

  16. Connolly SJ, Kerr CR, Gent M, et al. Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. N Engl J Med 2000; 342: 1385–1391.

    Article  PubMed  CAS  Google Scholar 

  17. Tang CY, Kerr CR, Connolly SJ. Clinical trials of pacing mode selection. Cardiology Clinics 2000; 18: 1–23.

    Article  PubMed  Google Scholar 

  18. Beck JR, Salem DN, Estes NA, Pauker SG. A computer-based Markov decision analysis of the management of symptomatic bifascicular block: the threshold probability for pacing. J Am Coll Cardiol 1987; 9: 920–935.

    Article  PubMed  CAS  Google Scholar 

  19. Eagle KA, Mulley AG, Singer DE, et al. Single-chamber and dual-chamber cardiac pacemakers: a formal cost comparison. Ann Intern Med 1986; 105: 264–271.

    PubMed  CAS  Google Scholar 

  20. Services MT. Pacemaker and ICD Encyclopedia. Medtronic, Inc., Minneapolis, MN, 2000.

    Google Scholar 

  21. Sutton R, Bourgeois I. Cost benefit analysis of single and dual chamber pacing for sick sinus syndrome and atrioventricular block. An economic sensitivity analysis of the literature. Eur Heart J 1996; 17: 574–582.

    Article  PubMed  CAS  Google Scholar 

  22. Lamas GA, Lee K, Sweeney M, et al. The mode selection trial (MOST) in sinus node dysfunction: design, rationale, and baseline characteristics of the first 1000 patients. Am Heart J 2000; 140: 541–551.

    Article  PubMed  CAS  Google Scholar 

  23. Toff WD, Skehan JD, de Bono DP, Camm AJ. The United Kingdom pacing and cardiovascular events (UKPACE) trial. Heart 1997; 78: 221–223.

    PubMed  CAS  Google Scholar 

  24. Wennberg DE, Birkmeyer JD. The Dartmouth Atlas of Cardiovascular Health Care. AHA Press, Chicago, IL, 1999.

    Google Scholar 

  25. Wennberg JE. On patient need, equity, supplier-induced demand, and the need to assess the outcome of common medical practice. Med Care 1985; 23: 512–520.

    Article  PubMed  CAS  Google Scholar 

  26. Gregoratos G, Cheitlin MD, Conill A, et al. ACC/AHA guidelines for implantation of cardiac pacemakers and antiarrhythmia devices: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 1998; 31: 1175–1209.

    Article  PubMed  CAS  Google Scholar 

  27. Echt DS, Liebson PR, Mitchell LB, et al. Mortality and morbidity in patients receiving encainide, flecainide or placebo: The Cardiac Arrhythmia Suppression Trial. N Engl J Med 1991; 324: 781–788.

    Article  PubMed  CAS  Google Scholar 

  28. Moss AJ, Hall WJ, Cannom DS, et.al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. N Engl J Med 1996; 335: 1933–1940.

    Article  PubMed  CAS  Google Scholar 

  29. Buxton AE, Lee KL, DiCarlo L, et.al. Electrophysiologic testing to identify patients with coronary artery disease who are at risk for sudden death: Multicenter Unsustained Tachycardia Trial Investigators. N Engl J Med 2000; 342: 1937–1945.

    Article  PubMed  CAS  Google Scholar 

  30. investigators TAvidA. Comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. N Engl J Med 1997; 337: 1576–1583.

    Article  Google Scholar 

  31. Kuck KH, Cappato R, Siebels J, Ruppel R. Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg. Circulation 2000; 102: 748–754.

    Article  PubMed  CAS  Google Scholar 

  32. O’Brien BJ. Chapter 3. Cost effectiveness of ICD therapy: a review of published evidence. Can J Cardiol 2000; 16: 1307–1312.

    PubMed  Google Scholar 

  33. Kuppermann M, Luce BR, McGovern B, et al. An analysis of the cost effectiveness of the implantable defibrillator. Circulation 1990; 81: 91–100.

    Article  PubMed  CAS  Google Scholar 

  34. O’Brien BJ, Buxton MJ, Rushby JA. Cost effectiveness of the implantable cardioverter defibrillator: a preliminary analysis. Br Heart J 1992; 68: 241–245.

    Article  PubMed  Google Scholar 

  35. Larsen GC, Manolis AS, Sonnenberg FA, et al. Cost-effectiveness of the implantable cardioverterdefibrillator: Effect of improved battery life and comparison with amiodarone therapy. J Am Coll Cardiol 1992; 12: 1323–1334.

    Article  Google Scholar 

  36. Kupersmith J, Hogan A, Guerrero P, et al. Evaluating and improving the cost-effectiveness of the implantable cardioverter-defibrillator. Am Heart J 1995; 130: 507–515.

    Article  PubMed  CAS  Google Scholar 

  37. Owens DK, Sanders GD, Harris RA, et al. Cost-effectiveness of implantable cardioverter defibrillators relative to amiodarone for prevention of sudden death. Ann Intern Med 1997; 126: 1–12.

    PubMed  CAS  Google Scholar 

  38. Laupacis A, Feeny D, Detsky AS, et al. How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations. CMAJ 1992; 146: 473–481.

    PubMed  CAS  Google Scholar 

  39. Chapman RH, Stone PW, Sandberg EA, et al. A comprehensive league table of cost-utility ratios and a sub-table of “panel-worthy” studies. Med Decis Making 2000; 20: 451–467.

    Article  PubMed  CAS  Google Scholar 

  40. Mushlin AI, Hall WJ, Zwanziger J, et al. The cost-effectiveness of automatic implantable cardiac defibrillators: results from MADIT. Multicenter Automatic Defibrillator Implantation Trial. Circulation 1998; 97: 2129–2135.

    Article  PubMed  CAS  Google Scholar 

  41. O’Brien BJ, Connolly SJ, Goeree R, et.al. Cost-effectiveness of the implantable cardioverter-defibrillator: results from the Canadian Implantable Defibrillator Study (CIDS). Circulation 2001; 103: 1416–1421.

    Article  PubMed  Google Scholar 

  42. Domanski MJ, Sakseena S, Epstein AE, et al. Relative effectiveness of the implantable cardioverterdefibrillator and antiarrhythmic drugs in patients with varying degrees of left ventricular dysfunction who have survived malignant ventricular arrhythmias. J Am Coll Cardiol 1999; 34: 1090–1095.

    Article  PubMed  CAS  Google Scholar 

  43. Moss AJ. Implantable cardioverter defibrillator therapy: the sickest patients benefit the most. Circulation 2000; 101: 1638–1664.

    Article  PubMed  CAS  Google Scholar 

  44. Connolly SJ, Hallstrom AP, Cappato R, et al. Meta-analysis of the implantable caradioverter defibrillator secondary prevention trials. Eur Heart J 2000; 21: 2071–2078.

    Article  PubMed  CAS  Google Scholar 

  45. Larsen G, Hallstrom A, McAnulty J, et al. Cost-effectiveness of the implantable cardioverter-defibrillator versus antiarrhythmic drugs in survivors of serious ventricular tachyarrhythmias. Results of the Antiarrhythmics Versus Implantable Defibrillators (AVID) economic analysis substudy. Circulation 2002; 105: 2049–2057.

    Article  PubMed  Google Scholar 

  46. Irvine J, Dorian P, Smith J, et al. Quality of life comparisons between the implantable cardioverter defibrillator and amiodarone. Psychosom Med 1999; 61 (Abstract): 114.

    Google Scholar 

  47. Orejarena LA, Vidaillet H, DeStefano F, et al. Paroxysmal supraventricular tachycardia in the general population. J Am Coll Cardiol 1998; 31: 150–157.

    Article  PubMed  CAS  Google Scholar 

  48. Larson MS, McDonald K, Young C, et al. Quality of life before and after radiofrequency catheter ablation in patients with drug refractory atrioventricular nodal reentrant tachycardia. Am J Cardiol 1999;84: 471–473, A9.

    Google Scholar 

  49. Kugler JD, Danford DA, Houston K, Felix G. Radiofrequency catheter ablation for paroxysmal supraventricular tachycardia in children and adolescents without structural heart disease. Pediatric EP Society, Radiofrequency Catheter Ablation Registry. Am J Cardiol 1997; 80: 1438–1443.

    Article  Google Scholar 

  50. Basta MN, Krahn AD, Klein GJ, et al. Safety of slow pathway ablation in patients with atrioventricular node reentrant tachycardia and a long fast pathway effective refractory period. Am J Cardiol 1997; 80: 155–159.

    Article  PubMed  CAS  Google Scholar 

  51. Scheinman MM. NASPE Survey on Catheter Ablation. Pac Clin Electrophysiol 1995; 18: 1474–1478.

    Article  CAS  Google Scholar 

  52. Calkins H, Yong P, Miller JM, et al. Catheter ablation of accessory pathways, atrioventricular nodal reentrant tachycardia, and the atrioventricular junction: final results of a prospective, multicenter clinical trial. The Atakr Multicenter Investigators Group. Circulation 1999; 99: 262–270.

    Article  PubMed  CAS  Google Scholar 

  53. Bubien RS, Knotts-Dolson SM, Plumb VJ, Kay GN. Effect of radiofrequency catheter ablation on health-related quality of life and activities of daily living in patients with recurrent arrhythmias. Circulation 1996; 94: 1585–1591.

    Article  PubMed  CAS  Google Scholar 

  54. Lau CP, Tai YT, Lee PW. The effects of radiofrequency ablation versus medical therapy on the quality-of-life and exercise capacity in patients with accessory pathway-mediated supraventricular tachycardia: a treatment comparison study. Pac Clin Electrophysiol 1995; 18: 424–432.

    Article  CAS  Google Scholar 

  55. Chen SA, Chiang CE, Tai CT, et al. Complications of diagnostic electrophysiologic studies and radiofrequency catheter ablation in patients with tachyarrhythmias: an eight-year survey of 3966 consecutive procedures in a tertiary referral center. Am J Cardiol 1996; 77: 41–46.

    Article  PubMed  CAS  Google Scholar 

  56. Thakur RK, Klein GJ, Yee R, Guiraudon GM. Complications of radiofrequency catheter ablation: a review. Can J Cardiol 1994; 10: 835–839.

    PubMed  CAS  Google Scholar 

  57. Hogenhuis W, Stevens SK, Wang P, et al. Cost-effectiveness of radiofrequency ablation compared with other strategies in Wolff-Parkinson-White syndrome. Circulation 1993;88:II437–I1446.

    Google Scholar 

  58. Cheng CH, Sanders GD, Hlatky MA, et al. Cost-effectiveness of radiofrequency ablation for supraventricular tachycardia. Ann Intern Med 2000; 133: 864–876.

    PubMed  CAS  Google Scholar 

  59. Fuster V, Ryden L. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: Executive summary. J Am Coll Cardiol 2001; 38: 1231–1265.

    Article  PubMed  CAS  Google Scholar 

  60. Falk R. Atrial fibrillation. N Engl J Med 2001; 344: 1067–1078.

    Article  PubMed  CAS  Google Scholar 

  61. Teng M, Catherwood E, Melby D. Cost Effectiveness of Therapies for Atrial Fibrillation. Pharmacoeconomics 2000; 18: 317–333.

    Article  PubMed  CAS  Google Scholar 

  62. Hart R, Benavente O, McBride R, Pearce L. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med 1999; 131: 492–501.

    PubMed  CAS  Google Scholar 

  63. Albers G, Dalen J, Laupacis A, et al. Antithrombotic therapy in atrial fibrillation. Chest 2001; 119: 194S - 206S.

    Article  PubMed  CAS  Google Scholar 

  64. Gage B, Waterman A, Shannon W, et al. Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. J Am Med Ass 2001; 285: 2864–2870.

    Article  CAS  Google Scholar 

  65. Kamath S, Lip G. Risk stratification for thromboprophylaxis in atrial fibrillation. Cardiac Electrophysiol Rev 2001; 5: 171–178.

    Article  Google Scholar 

  66. Gage BF, Cardinalli AB, Albers GW, Owens DK. Cost-effectiveness of warfarin and aspirin for prophylaxis of stroke in patients with nonvalvular atrial fibrillation [see comments]. JAMA 1995; 274: 1839–1845.

    Article  PubMed  CAS  Google Scholar 

  67. Eckman MH, Levine HJ, Salem DN, Pauker SG. Making decisions about antithrombotic therapy in heart disease: decision analytic and cost-effectiveness issues. Chest 1998; 114: 699S - 714S.

    Article  PubMed  CAS  Google Scholar 

  68. Hylek EM, Skates SJ, Sheehan MA, Singer DE. An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation. N Engl J Med 1996; 335: 540–654.

    Article  PubMed  CAS  Google Scholar 

  69. Group TEAFTS. Optimal oral anticoagulation therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia. N Engl J Med 1995; 333: 5–10.

    Article  Google Scholar 

  70. Hirsh J, Dalen JE, Deykin D, et al. Oral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 1995; 108: 2315–2465.

    Google Scholar 

  71. Ellenbogen KA, Clemo HF, Stambler BS, Wood MA, VanderLugt JT. Efficacy of ibutilide for termination of atrial fibrillation and flutter. Am J Cardiol 1996; 78: 42–45.

    Article  PubMed  CAS  Google Scholar 

  72. Foster RH, Wilde MI, Markham A. Ibutilide. A review of its pharmacological properties and clinical potential in the acute management of atrial flutter and fibrillation. Drugs 1997; 54: 312–330.

    Article  PubMed  CAS  Google Scholar 

  73. Oral H, Souza JJ, Michaud GF, et al. Facilitating transthoracic cardioversion of atrial fibrillation with ibutilide pretreatment [see comments]. N Engl J Med 1999; 340: 1849–1854.

    Article  PubMed  CAS  Google Scholar 

  74. Grace AA, Camm AJ. Quinidine. N Engl J Med 1998; 338: 35–45.

    CAS  Google Scholar 

  75. Volgman AS, Carberry PA, Stambler B, et al. Conversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation. J Am Coll Cardiol 1998; 31: 1414–1419.

    Article  PubMed  CAS  Google Scholar 

  76. Lundstrom T, Ryden L. Chronic atrial fibrillation. Long-term results of direct current conversion. Acta Med Scand 1988; 223: 53–59.

    CAS  Google Scholar 

  77. Reimold SC, Maisel WH, Antman EM. Propafenone for the treatment of supraventricular tachycardia and atrial fibrillation: a meta-analysis. Am J Cardiol 1998; 82: 66N - 71N.

    Article  PubMed  CAS  Google Scholar 

  78. Naccarelli GV, Dorian P, Hohnloser SH, Coumel P. Prospective comparison of flecainide versus quinidine for the treatment of paroxysmal atrial fibrillation/flutter. The Flecainide Multicenter Atrial Fibrillation Study Group. Am J Cardiol 1996; 77: 53A - 59A.

    Article  PubMed  CAS  Google Scholar 

  79. Falk RH, Pollak A, Singh SN, Friedrich T. Intravenous dofetilide, a class III antiarrhythmic agent, for the termination of sustained atrial fibrillation or flutter. Intravenous Dofetilide Investigators [see comments]. J Am Coll Cardiol 1997; 29: 385–390.

    Article  PubMed  CAS  Google Scholar 

  80. Norgaard BL, Wachtell K, Christensen PD, et al. Efficacy and safety of intravenously administered dofetilide in acute termination of atrial fibrillation and flutter: a multicenter, randomized, double-blind, placebo-controlled trial. Danish Dofetilide in Atrial Fibrillation and Flutter Study Group. Am Heart J 1999; 137: 1062–1069.

    Article  PubMed  CAS  Google Scholar 

  81. Zarembski DG, Nolan PE, Jr., Slack MK, Caruso AC. Treatment of resistant atrial fibrillation. A meta-analysis comparing amiodarone and flecainide. Arch Intern Med 1995; 155: 1885–1891.

    Article  PubMed  CAS  Google Scholar 

  82. Podrid PJ. Amiodarone: reevaluation of an old drug. Ann Intern Med 1995; 122: 689–700.

    PubMed  CAS  Google Scholar 

  83. Opolski G, Stanislawska J, Gorecki A, et al. Amiodarone in restoration and maintenance of sinus rhythm in patients with chronic atrial fibrillation after unsuccessful direct-current cardioversion. Clin Cardiol 1997; 20: 337–340.

    Article  PubMed  CAS  Google Scholar 

  84. Stafford RS, Robson DC, Misra B, et al. Rate control and sinus rhythm maintenance in atrial fibrillation: national trends in medication use, 1980–1996. Arch Intern Med 1998; 158: 2144–2148.

    Article  PubMed  CAS  Google Scholar 

  85. Reiffel JA. Selecting an antiarrhythmic agent for atrial fibrillation should be a patient-specific, data-driven decision. Am J Cardiol 1998; 82: 72N - 81N.

    Article  PubMed  CAS  Google Scholar 

  86. Danias P, Caulfield T, Weigner M, et al. Likelihood of spontaneous conversion of atrial fibrillation to sinus rhythm. J Am Coll Cardiol 1998; 31: 588–592.

    Article  PubMed  CAS  Google Scholar 

  87. Kowey PR, Marinchak RA, Rials SJ, Filart RA. Acute treatment of atrial fibrillation. Am J Cardiol 1998; 81: 16C - 22C.

    Article  PubMed  CAS  Google Scholar 

  88. Naccarelli GV, Dell’Orfano JT, Wolbrette DL, et al. Cost-effective management of acute atrial fibrillation: Role of rate control, spontaneous conversion, medical and direct current cardioversion, trans-esophageal echocardiography, and antiembolic therapy. Am J Cardiol 2000; 85: 36D - 45D.

    Article  PubMed  CAS  Google Scholar 

  89. Murdock DK, Schumock GT, Kaliebe J, et al. Clinical and cost comparison of ibutilide and direct-current cardioversion for atrial fibrillation and flutter. Am J Cardiol 2000;85: 503–506, A11.

    Google Scholar 

  90. Li H, Natale A, Tomassoni G, et al. Usefulness of ibutilide in facilitating successful external cardioversion of refractory atrial fibrillation. American J Cardiol 1999;84: 1096–1098, A10.

    Google Scholar 

  91. Murray KT. Ibutilide. Circulation 1998; 97: 493–497.

    Article  PubMed  CAS  Google Scholar 

  92. Catherwood E, Fitzpatrick WD, Greenberg ML, et al. Cost-effectiveness of cardioversion and antiarrhythmic therapy in nonvalvular atrial fibrillation [see comments]. Ann Intern Med 1999; 130: 625–636.

    PubMed  CAS  Google Scholar 

  93. Eckman MH, Falk RH, Pauker SG. Cost-effectiveness of therapies for patients with nonvalvular atrial fibrillation. Arc Intern Med 1998; 158: 1669–1677.

    Article  CAS  Google Scholar 

  94. Vorperian VR, Havighurst TC, Miller S, January CT. Adverse effects of low dose amiodarone: a meta-analysis. J Am Coll Cardiol 1997; 30: 791–798.

    Article  PubMed  CAS  Google Scholar 

  95. Jessurun GAJ, Crijns HJGM. Amiodarone pulmonary toxicity. Br Med J 1997; 314: 619–620.

    Article  CAS  Google Scholar 

  96. Inoue H, Atarashi H. Risk factors for thromboembolism in patients with paroxysmal atrial fibrillation. Am J Cardiol 2000; 86: 852–855.

    Article  PubMed  CAS  Google Scholar 

  97. Pauker S, Eckman M. Finding what you seek: analyzing therapies for nonvalvular atrial fibrillation. Ann Intern Med 1999; 130: 690–691.

    PubMed  CAS  Google Scholar 

  98. Study PaSCotA. Atrial Fibrillation Follow-Up Investigation of Rhythm Managemen-The AFFIRM Study Design. Am J Cardiol 1997; 79: 1198–1202.

    Article  Google Scholar 

  99. Maisel WH, Kuntz KM, Reimold SC, et al. Risk of initiating antiarrhythmic drug therapy for atrial fibrillation in patients admitted to a university hospital. Ann Intern Med 1997; 127: 281–284.

    PubMed  CAS  Google Scholar 

  100. Friedman PL, Stevenson WG. Proarrhythmia. Am J Cardiol 1998; 82: 50N - 58N.

    CAS  Google Scholar 

  101. Fiaker GC, Blackshear JL, McBride R, et al. Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. Journal Am Coll Cardiology 1992; 20: 527–532.

    Article  Google Scholar 

  102. Chung MK, Schweikert RA, Wilkoff BL, et al. Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required? Yield of in-hospital monitoring and prediction of risk for significant arrhythmia complications. J Am Coll Cardiol 1998; 32: 169–176.

    Article  PubMed  CAS  Google Scholar 

  103. Pinski SL, Helguera ME. Antiarrhythmic drug initiation in patients with atrial fibrillation. Prog Card Dis 1999; 42: 75–90.

    Article  CAS  Google Scholar 

  104. Simons G, Eisenstein E, Shaw L, et al. Cost-effectiveness of inpatient initiation of antiarrhythmic therapy for supraventricular tachycardias. Am J Cardiol 1997; 80: 1551–1557.

    Article  PubMed  CAS  Google Scholar 

  105. Marcus FI. Risks of initiating therapy with sotalol for treatment of atrial fibrillation. J Am Coll Cardiol 1998; 32: 177–180.

    Article  PubMed  CAS  Google Scholar 

  106. Mayet J, More RS, Sutton GC. Anticoagulation for cardioversion of atrial arrhythmias. Eur Heart J 1998; 19: 548–552.

    Article  PubMed  CAS  Google Scholar 

  107. Grimm R, Stewart W, Black I, et al. Should all patients undergo transesophageal echocardiography before electrical cardioversion of atrial fibrillation. J Am Coll Cardiol 1994; 23: 533–541.

    Article  PubMed  CAS  Google Scholar 

  108. Black I, Fatkin D, Sagar K, et al. Exclusion of atrial thrombus by transesophageal echocardiography does not preclude embolism after cardioversion of atrial fibrillation. Circulation 1994; 89: 2509–2513.

    Article  PubMed  CAS  Google Scholar 

  109. Manning W, Silverman D, Keighley C, et al. Transesophageal echocardiographically facilitated early cardioversion from atrial fibrillation using short-term anticoagulation: Final results of a prospective 4.5-year study. J Am Coll Cardiol 1995; 25: 1354–1361.

    Article  PubMed  CAS  Google Scholar 

  110. Manning W, Weintraub R, Waksmonski C, et al. Accuracy of transesophageal echocardiography for identifying left atrial thrombi. Ann Intern Med 1995; 123: 817–822.

    PubMed  CAS  Google Scholar 

  111. Seto TB, Taira DA, Tsevat J, Manning WJ. Cost-effectiveness of transesophageal echocardiographicguided cardioversion: a decision analytic model for patients admitted to the hospital with atrial fibrillation. J Am Coll Cardiol 1997; 29: 122–130.

    Article  PubMed  CAS  Google Scholar 

  112. Klein A, Grimm R, Murray D, et al. Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation. N Engl J Med 2001; 344: 1411–1420.

    Article  PubMed  CAS  Google Scholar 

  113. Roy D, Talajic M, Dorian P, et al. Amiodarone to prevent recurrences of atrial fibrillation. N Engl J Med 2000; 342: 913–920.

    Article  PubMed  CAS  Google Scholar 

  114. Guerra P, Lesh M. The role of nonpharmacologic therapies for the treatment of atrial fibrillation. J Card Electrophysiol 1999; 10: 450–460.

    Article  CAS  Google Scholar 

  115. Cannom DS. Atrial fibrillation: nonpharmacologic approaches. Am J Cardiol 2000; 85: 25D - 35D.

    Article  PubMed  CAS  Google Scholar 

  116. Narasimhan C, Blanck Z, Akhtar M. Atrioventricular nodal modification and atrioventricular junctional ablation for control of ventricular rate in atrial fibrillation. J Card Electrophysiol 1997; 9: S146 — S150.

    Google Scholar 

  117. Brignole M, Menozzi C, Gianfrachi L, et al. Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation. Circulation 1998; 98: 953–960.

    Article  PubMed  CAS  Google Scholar 

  118. Haissaguerre M, Shah D, Jais P. Role of catheter ablation for atrial fibrillation. Curr Opin Cardiol 1997; 12: 18–23.

    Article  PubMed  CAS  Google Scholar 

  119. Lau C, Tse H, Lok N, et al. Initial experience with an implantable human atrial defibrillator. PACE 1997; 20: 220–225.

    Article  PubMed  CAS  Google Scholar 

  120. Ezekowitz M. Atrial fibrillation: the epidemic of the new millenium. Ann Intern Med 1999; 131: 537–538.

    PubMed  CAS  Google Scholar 

  121. Kowey PR, Marinchak RA, Rials SJ, et al. Atrial fibrillation trials: will they teach us what we need to know? Am J Cardiol 1998; 82: 86N - 91N.

    Article  PubMed  CAS  Google Scholar 

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© 2003 Humana Press Inc., Totowa, NJ

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Malenka, D.J., Catherwood, E. (2003). Cost-Effective Care in the Management of Conduction Disease and Arrhythmias. In: Weintraub, W.S. (eds) Cardiovascular Health Care Economics. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-398-9_18

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  • DOI: https://doi.org/10.1007/978-1-59259-398-9_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9784-7

  • Online ISBN: 978-1-59259-398-9

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