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Androgens and Cognition

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Androgens in Health and Disease

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Androgens and their effects on behavior have been an area of study for over a century. In 1889, Brown-Sequard, using himself as case study, injected an extract from crushed animal testicles. He reported that this treatment gave him increased energy, muscular strength, stamina and mental agility (1). Although crude, this approach led the way to the discovery of androgens. Since then, the focus of most androgen research has been in the area of reproductive function. More recently, the focus of attention has turned to hormone effects on the central nervous system (CNS) and aging, with particular emphasis on potential antiaging effects of hormone replacement therapy. This chapter will explore the complex relationship between androgens and cognition. We will first describe mechanisms by which hormones exert their effects in the CNS, including organizational and activational effects. Next, we will examine the relationship of androgens and cognition in humans, including endogenous levels and studies examining hormone manipulation in healthy young and older populations. Finally, we will examine the relationship between androgens and cognition as expressed through endocrine disorders that result in excessive or insufficient hormone levels. This chapter will feature cognition rather than mood, emotion, or other aspects of human behavior. Readers may refer to other chapters in this volume or Rubinow and Schmidt (1996) for a review of the relationship between androgens and mood or behavior (2).

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  1. Monique M. Cherrier PhD
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  2. Suzanne Craft PhD
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Editors and Affiliations

  1. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA

    Carrie J. Bagatell MD (Clinical Assistant Professor) & William J. Bremner MD, PhD (The Robert G. Petersdorf Professor and Chairman) (Clinical Assistant Professor) &  (The Robert G. Petersdorf Professor and Chairman)

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Cherrier, M.M., Craft, S. (2003). Androgens and Cognition. In: Bagatell, C.J., Bremner, W.J. (eds) Androgens in Health and Disease. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-388-0_15

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  • DOI: https://doi.org/10.1007/978-1-59259-388-0_15

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