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Expression Profiling of Human Tumors pp 235–255Cite as

Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications

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Abstract

Renal cell carcinoma (RCC) is the most common malignancy arising in the adult kidney, representing 2% of all malignancies and 2% of cancer-related deaths. It is the 10th most common cancer in the U.S., where it causes more than 12,000 deaths per year. Its incidence has been increasing, a phenomenon that cannot be accounted for by the wider use of imaging procedures (1). RCC is more common in men than women, especially in men over 55 yr of age. Risk factors include genetic predisposition (2), hypertension, obesity (3),and occupational exposures (4). RCC may be as small as 1 cm in diameter when discovered (usually incidentally), or as bulky as several kilograms. It most often manifests with pain, as a palpable mass, as hematuria, or as another paraneoplastic syndrome.

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References

  1. Chow, W. H., Devesa, S. S., Warren, J. L., and Fraumeni, J. F., Jr. (1999) Rising incidence of renal cell cancer in the United States. JAMA 281, 1628–1631.

    Article  PubMed  CAS  Google Scholar 

  2. Takahashi, M., Kahnoski, R., Gross, D., Nicol, D., and Teh, B. T. (2002) Familial adult renal neoplasia. J. Med. Genet. 39, 1–5.

    Article  PubMed  CAS  Google Scholar 

  3. Chow, W. H., Gridley, G., Fraumeni, J. F., Jr., and Jarvholm, B. (2000) Obesity, hypertension, and the risk of kidney cancer in men. N. Engl. J. Med. 343, 1305–1311.

    Article  PubMed  CAS  Google Scholar 

  4. Moyad, M. A. (2001) Review of potential risk factors for kidney (renal cell) cancer. Semin. Urol. Oncol. 19, 280–293.

    PubMed  CAS  Google Scholar 

  5. Mostofi, F. K. and Davis, C. J. (1998) International Histological Classification of Tumors. Springer, Berlin.

    Google Scholar 

  6. Bugert, P. and Kovacs, G. (1996) Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis. Am. J. Pathol. 149, 2081–2088.

    PubMed  CAS  Google Scholar 

  7. Storkel, S., Eble, J. N., Adlakha, K., et al. (1997) Classification of renal cell carcinoma: Workgroup No. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Cancer 80, 987–989.

    Google Scholar 

  8. Presti, J. C., Jr., Moch, H., Reuter, V. E., Huynh, D., and Waldman, F. M. (1996) Comparative genomic hybridization for genetic analysis of renal oncocytomas. Genes Chromosom. Cancer 17, 199–204.

    Article  PubMed  CAS  Google Scholar 

  9. Flanigan, R. C., Salmon, S. E., Blumenstein, B. A., et al. (2001) Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N. Engl. J. Med. 345, 1655–1659.

    Article  PubMed  CAS  Google Scholar 

  10. Kish, J. A., Wolf, M., Crawford, E. D., et al. (1994) Evaluation of low dose continuous infusion 5-fluorouracil in patients with advanced and recurrent renal cell carcinoma. A Southwest Oncology Group Study. Cancer 74, 916–919.

    Article  PubMed  CAS  Google Scholar 

  11. Einzig, A. I., Gorowski, E., Sasloff, J., and Wiernik, P. H. (1991) Phase II trial of taxol in patients with metastatic renal cell carcinoma. Cancer Invest. 9, 133–136.

    Article  PubMed  CAS  Google Scholar 

  12. Fossa, S. D., Droz, J. P., Pavone-Macaluso, M. M., Debruyne, F. J., Vermeylen, K., and Sylvester, R. (1992) Vinblastine in metastatic renal cell carcinoma: EORTC phase II trial 30882. The EORTC Genitourinary Group. Eur. J. Cancer 28A, 878–880.

    Article  Google Scholar 

  13. Atzpodien, J., Kirchner, H., Illiger, H. J., et al. (2001) IL-2 in combination with IFN- alpha and 5-FU versus tamoxifen in metastatic renal cell carcinoma: long-term results of a controlled randomized clinical trial. Br. J. Cancer 85, 1130–1136.

    Article  PubMed  CAS  Google Scholar 

  14. Schomburg, A., Kirchner, H., Fenner, M., Menzel, T., Poliwoda, H., and Atzpodien, J. (1993) Lack of therapeutic efficacy of tamoxifen in advanced renal cell carcinoma. Eur. J. Cancer 29A, 737–740.

    Article  Google Scholar 

  15. Minasian, L. M., Motzer, R. J., Gluck, L., Mazumdar, M., Vlamis, V., and Krown, S. E. (1993) Interferon alfa-2a in advanced renal cell carcinoma: treatment results and survival in 159 patients with long-term follow-up. J. Clin. Oncol. 11, 1368–1375.

    Google Scholar 

  16. Vogelzang, N. J., Lipton, A., and Figlin, R. A. (1993) Subcutaneous interleukin-2 plus interferon alfa-2a in metastatic renal cancer: an outpatient multicenter trial. J. Clin. Oncol. 11, 1809–1816.

    PubMed  CAS  Google Scholar 

  17. Atkins, M. B., Sparano, J., Fisher, R. I., et al. (1993) Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma. J. Clin. Oncol. 11, 661–670.

    PubMed  CAS  Google Scholar 

  18. Ellerhorst, J. A., Sella, A., Amato, R. J., et al. (1997) Phase II trial of 5-fluorouracil, interferon-alpha and continuous infusion interleukin-2 for patients with metastatic renal cell carcinoma. Cancer 80, 2128–2132.

    Google Scholar 

  19. Childs, R., Chernoff, A., Contentin, N., et al. (2000) Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N. Engl. J. Med. 343, 750–758.

    Article  PubMed  CAS  Google Scholar 

  20. Levy, D. A., Slaton, J. W., Swanson, D. A., and Dinney, C. P. (1998) Stage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma. J. Urol. 159, 1163–1167.

    Article  PubMed  CAS  Google Scholar 

  21. Ljungberg, B., Alamdari, F. I., Rasmuson, T., and Roos, G. (1999) Follow-up guidelines for nonmetastatic renal cell carcinoma based on the occurrence of metastases after radical nephrectomy. BJU Int. 84, 405–411.

    Article  PubMed  CAS  Google Scholar 

  22. Hermanek, P. and Schrott, K. M. (1990) Evaluation of the new tumor, nodes and metastases classification of renal cell carcinoma../. Urol. 144, 238–242.

    CAS  Google Scholar 

  23. Henson, D. E., Fielding, L. P., Grignon, D. J., et al. (1995) College of American Pathologists Conference XXVI on clinical relevance of prognostic markers in solid tumors. Summary. Members of the Cancer Committee. Arch. Pathol. Lab. Med. 119, 1109–1112.

    PubMed  CAS  Google Scholar 

  24. Tsui, K. H., Shvarts, O., Smith, R. B., Figlin, R. A., deKernion, J. B., and Belldegrun, A. (2000) Prognostic indicators for renal cell carcinoma: a multivariate analysis of 643 patients using the revised 1997 TNM staging criteria. J. Urol. 163, 1090–1095.

    Article  PubMed  CAS  Google Scholar 

  25. Gettman, M. T., Blute, M. L., Spotts, B., Bryant, S. C., and Zincke, H. (2001) Pathologic staging of renal cell carcinoma: significance of tumor classification with the 1997 TNM staging system. Cancer 91, 354–361.

    Article  PubMed  CAS  Google Scholar 

  26. Moch, H., Gasser, T., Amin, M. B., Torhorst, J., Sauter, G., and Mihatsch, M. J. (2000) Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors. Cancer 89, 604–614.

    Article  PubMed  CAS  Google Scholar 

  27. Ono, K., Tanaka, T., Tsunoda, T., et al. (2000) Identification by cDNA microarray of genes involved in ovarian carcinogenesis. Cancer Res. 60, 5007–5011.

    PubMed  CAS  Google Scholar 

  28. Golub, T. R., Slonim, D. K., Tamayo, P., et al. (1999) Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531–537.

    Article  PubMed  CAS  Google Scholar 

  29. Hedenfalk, I., Duggan, D., Chen, Y., et al. (2001) Gene-expression profiles in hereditary breast cancer. N. Engl. J. Med. 344, 539–548.

    Article  PubMed  CAS  Google Scholar 

  30. Okabe, H., Satoh, S., Kato, T., et al. (2001) Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res. 61, 2129–2137.

    PubMed  CAS  Google Scholar 

  31. Alizadeh, A. A., Eisen, M. B., Davis, R. E., et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503–511.

    Article  PubMed  CAS  Google Scholar 

  32. Sorlie, T., Perou, C. M., Tibshirani, R., et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA 98, 10,869–10, 874.

    Google Scholar 

  33. Bhattacharjee, A., Richards, W. G., Staunton, J., et al. (2001) Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc. Natl. Acad. Sci. USA 98, 13,790–13, 795.

    Google Scholar 

  34. Pomeroy, S. L., Tamayo, P., Gaasenbeek, M., et al. (2002) Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415, 436–442.

    Article  PubMed  CAS  Google Scholar 

  35. Moch, H., Schraml, P., Bubendorf, L., et al. (1999) High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma. Am. J. Pathol. 154, 981–986.

    Article  PubMed  CAS  Google Scholar 

  36. Dierick, A. M., Praet, M., Roels, H., Verbeeck, P., Robyns, C., and Oosterlinck, W. (1991) Vimentin expression of renal cell carcinoma in relation to DNA content and histological grading: a combined light microscopic, immunocytochemical and cytophotometrical analysis. Histopathology 18, 315–322.

    Article  PubMed  CAS  Google Scholar 

  37. Beham, A., Ratschek, M., Zatloukal, K., Schmid, C., and Denk, H. (1992) Distribution of cytokeratins, vimentin and desmoplakins in normal renal tissue, renal cell carcinomas and oncocytoma as revealed by immunofluorescence microscopy. Virchows Arch. A Pathol. Anat. Histopathol. 421, 209–215.

    Article  PubMed  CAS  Google Scholar 

  38. Young, A. N., Amin, M. B., Moreno, C. S., et al. (2001) Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers. Am. J. Pathol. 158, 1639–1651.

    Article  PubMed  CAS  Google Scholar 

  39. Eisen, M. B., Spellman, P. T., Brown, P. 0., and Botstein, D. (1998) Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95, 14, 86314, 868.

    Google Scholar 

  40. Heyer, L. J., Kruglyak, S., and Yooseph, S. (1999) Exploring expression data: identification and analysis of coexpressed genes. Genome Res. 9, 1106–1115.

    Article  PubMed  CAS  Google Scholar 

  41. Bindels, R. J., Timmermans, J. A., Hartog, A., Coers, W., and van Os, C. H. (1991) Calbindin-D9k and parvalbumin are exclusively located along basolateral membranes in rat distal nephron. J. Am. Soc. Nephrol. 2, 1122–1129.

    PubMed  CAS  Google Scholar 

  42. Valore, E. V., Park, C. H., Quayle, A. J., Wiles, K. R., McCray, P. B., Jr., and Ganz, T. (1998) Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101, 1633–1642.

    Google Scholar 

  43. Khoo, S. K., Bradley, M., Wong, F. K., Hedblad, M. A., Nordenskjold, M., and Teh, B. T. (2001) Birt-Hogg-Dube syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12–811.2. Oncogene 20, 5239–5242.

    Article  PubMed  CAS  Google Scholar 

  44. Boer, J. M., Huber, W. K., Sultmann, H., et al. (2001) Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array. Genome Res. 11, 1861–1870.

    PubMed  CAS  Google Scholar 

  45. Takahashi, M., Rhodes, D. R., Furge, K. A., et al. (2001) Gene expression profiling of clear cell renal cell carcinoma: gene identification and prognostic classification. Proc. Natl. Acad. Sci. USA 98, 9754–9759.

    Article  PubMed  CAS  Google Scholar 

  46. Saito, K., Saito, T., Draganac, P. S., et al. (1985) Secretion of ceruloplasmin by a human clear cell carcinoma maintained in nude mice. Biochem. Med. 33, 45–52.

    Article  PubMed  CAS  Google Scholar 

  47. Pejovic, M., Djordjevic, V., Ignjatovic, I., Stamenic, T., and Stefanovic, V. (1997) Serum levels of some acute phase proteins in kidney and urinary tract urothelial cancers. Int. Urol. Nephrol. 29, 427–432.

    Article  PubMed  CAS  Google Scholar 

  48. Kirschmann, D. A., Seftor, E. A., Nieva, D. R., Mariano, E. A., and Hendrix, M. J. (1999) Differentially expressed genes associated with the metastatic phenotype in breast cancer. Breast Cancer Res. Treat. 55, 127–136.

    Article  PubMed  CAS  Google Scholar 

  49. Thompson, T. C. (1998) Metastasis-related genes in prostate cancer: the role of caveolin-1. Cancer Metastasis Rev. 17, 439–442.

    Article  PubMed  CAS  Google Scholar 

  50. Zhang, J. C., Claffey, K., Sakthivel, R., et al. (2000) Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5. FASEB J. 14, 2589–2600.

    Article  PubMed  CAS  Google Scholar 

  51. Janssen, A. M., van Duijn, W., Oostendorp-Van De Ruit, M. M., et al. (2000) Metallothionein in human gastrointestinal cancer [in process citation]. J. Pathol. 192, 293–300.

    Google Scholar 

  52. Nguyen, A., Jing, Z., Mahoney, P. S., et al. (2000) In vivo gene expression profile analysis of metallothionein in renal cell carcinoma. Cancer Lett. 160, 133–140.

    Article  PubMed  CAS  Google Scholar 

  53. Izawa, J. I., Moussa, M., Cherian, M. G., Doig, G., and Chin, J. L. (1998) Metallothionein expression in renal cancer. Urology 52, 767–772.

    Article  PubMed  CAS  Google Scholar 

  54. Zhu, Y. Y., Takashi, M., Miyake, K., and Kato, K. (1991) An immunochemical and immunohistochemical study of aldolase isozymes in renal cell carcinoma. J. Urol. 146, 469–472.

    PubMed  CAS  Google Scholar 

  55. Xiang, Y. Y., Ladeda, V., and Filmus, J. (2001) Glypican-3 expression is silenced in human breast cancer. Oncogene 20, 7408–7412.

    Article  PubMed  CAS  Google Scholar 

  56. Cano-Gauci, D. F., Song, H. H., Yang, H., et al. (1999) Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-GolabiBehmel syndrome. J. Cell Biol. 146, 255–264.

    PubMed  CAS  Google Scholar 

  57. Ashburner, M., Ball, C. A., Blake, J. A., et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25–29.

    Article  PubMed  CAS  Google Scholar 

  58. Rhodes, D. R., Miller, J. C., Haab, B. B., and Furge, K. A. (2002) CIT: identification of differentially expressed clusters of genes from microarray data. Bioinformatics 18, 205–206.

    Article  PubMed  CAS  Google Scholar 

  59. Engel, J. D., Kundu, S. D., Yang, T., et al. (1999) Transforming growth factor-beta type II receptor confers tumor suppressor activity in murine renal carcinoma (Renca) cells. Urology 54, 164–170.

    Article  PubMed  CAS  Google Scholar 

  60. Bachman, K. E., Herman, J. G., Corn, P. G., et al. (1999) Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res. 59, 798–802.

    PubMed  CAS  Google Scholar 

  61. Ahonen, M., Baker, A. H., and Kahari, V. M. (1998) Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. Cancer Res. 58, 2310–2315.

    PubMed  CAS  Google Scholar 

  62. Parry, L., Maynard, J. H., Patel, A., et al. (2001) Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas. Br. J. Cancer 85, 1226–1230.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Masayuki Takahashi
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  2. Bin Tean Teh
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Editors and Affiliations

  1. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Marc Ladanyi MD  & William L. Gerald MD, PhD  & 

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Takahashi, M., Teh, B.T. (2003). Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications. In: Ladanyi, M., Gerald, W.L. (eds) Expression Profiling of Human Tumors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-386-6_13

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  • DOI: https://doi.org/10.1007/978-1-59259-386-6_13

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-375-6

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