Abstract
It was once believed that the nervous system and immune system were separate and independent systems, each with their own regulatory systems. However, it is now clear, that these systems overlap and communicate extensively on a continuous basis, both as a part of normal function and in disease and trauma. It has been clearly shown that these two systems share common receptors and ligands for hormones, neurotransmitters, and cytokines that form the basis for this communication. In addition, as discussed here, the central nervous system (CNS) is not exclusively “immunoprivileged”, although it does have the capacity to limit the activation of an inflammatory response under many circumstances.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Selected Readings
Ader R, Felten DL, Cohen N. (eds). Psychoneuroimmunology, 3rd ed. Academic Press, San Diego, 2001.
Antel J, Bernbaum G, Hartung HP. (eds). Clinical Neuroimmunology. Malden, MA: Blackwell Science, 1998.
Keane RW, Hickey WF. (eds). Immunology of the Nervous System. New York: Oxford University Press, 1997.
Martino G, Adorini L. (eds). From Basic Immunology to Immune-Mediated Demyelination. New York; Milano: Springer, 1999.
Martino G, Furlan R, Brambilla E, Bergami A, Ruffini F, Gironi M, et al. Cytokines and immunity in multiple sclerosis: the dual signal hypothesis. J Neuroimmunol 2000; 109: 3–9.
Ransohoff R, Benveniste E. (eds) Cytokines and the CNS. Boca Raton: CRC Press, 1996.
Rolak L, Harati Y. (eds) Neuroimmunology for the Clinician. Boston: Butterworth-Heinmann, 1997.
Rothwell NJ. (ed). Cytokines in the Nervous System. Austin: RG Landes, 1996.
Scharrer B, Smith EM, Stefano GB. (eds). Neuropeptides and Immunoregulation. Berlin; New York: Springer-Verlag, 1994.
Massey JM. Acquired myasthenia gravis. Neurologic Clinics 1997; 15: 577–595.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Carlson, S.L., Cooper, G., Rodnitzky, R.L. (2003). Nervous System. In: Conn, P.M. (eds) Neuroscience in Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-371-2_31
Download citation
DOI: https://doi.org/10.1007/978-1-59259-371-2_31
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4757-5975-4
Online ISBN: 978-1-59259-371-2
eBook Packages: Springer Book Archive