Abstract
Aside from the discovery of the cardiac conduction system (Table 1) and advancements in the electrotherapy of cardiac arrhythmias (Table 2), the development of electrocardiography was the key issue for a more detailed understanding of arrhythmogenesis as a cause and correlate of cardiac disorders (Table 3). After the first documentation of a cardiac action potential by Rudolph von Koelliker and Heinrich Müller in 1856, two decades later Augustus Desiré Waller (Fig. 1) recorded the first human electrocardiogram. After qualifying as a medical doctor Waller joined the department of physiology at the University of London where he studied in John Burdon Sanderson’s laboratories the electrical activity of the excised mammalian heart. In 1884 he was appointed lecturer in physiology at St. Mary’s Hospital London where he used a capillary electrometer, an instrument invented 15 yr earlier by the French scientist Gabriel Lippmann, to record cardiac potentials in animals (Fig. 2). In 1887, he was able to obtain the first human electrocardiogram from the body surface and published his findings in the Journal of Physiology: “A demonstration on man of electromotive changes accompanying the hearts beat (45).” Waller also proved that the electrical phenomenon preceded the muscle contraction, thus excluding the possibility that the recorded activity was only an artifact.
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References
Purkinje JE. Mikroskopisch-neurologische Beobachtungen. Arch Anat Physiol Wiss Med II/III:281–295.
Paladino G. Contribuzione all’Anatomia, Istologia e Fisilogia del Cuore. Napoli: Movim Med Chir, 1876.
His W Jr. Die Tatigkeit des embryonalen Herzens und deren Bedeutung fur die Lehre von der Herzbewegung beim Erwachsenen. Arb Med Klin 1893; 14–49.
Aschoff L, Tawara S. Die heutige Lehre von den pathologisch-anatomischen Grundlagen der Herzschwache. Kritische Bemerkungen auf Grund eigener Untersuchungen. Jena, Fischer, 1906.
Wenckebach KF. Beitrage zur Kenntnis der menschlichen Herztatigkeit. Arch Anat Physiol 1906; 297–354.
Keith A, Flack M. The form and nature of the muscular connections between the primary divisions of the vertebrate heart. J Anat Physiol 1907;41:172–189.
Bachmann G. The inter-auricular time interval. Am J Physiol 1916;41:309–320.
Mahaim I. Kent fibers and the AV paraspecific conduction through the upper connections of the bundle of His-Tawara. Am Heart J 1947;33:651–653.
James TN. Morphology of the human atrioventricular node with remarks pertinent to its electrophysi-ology. Am Heart J 1961;62:756–771.
Hirsch A, ed. Biographisches Lexikon der hervorragenden Arzte aller Zeiten und Volker. 3.Aufl. Bd. IV. München, Urban & Schwarzenberg, 1929.
Volavsek B, ed. Marko Gerbec. Marcus Gerbezius 1658–1718. Syndroma Gerbezius-Morgagni-Adams-Stokes. Ljubljana, 1977.
Cammilli L, Feruglio GA. Breve cronistoria della cardiostimolazione elettrica date, uomini e fatti da ricordare. Publicazione Distribuita in Occcasione des Secondo Simposio Europeo di Cardiostimolazione. Firenze, 3–6 Maggio, 1981.
Galvani L. De viribus electricitatis in motu musculari commentarius. Bologna Inst Sci, 1791.
Bichat MFX. Recherches physiologiques sur la vie et la mort. Paris, Fournier, 1804.
Aldini G. Essai theorique et experimental sur le galvanisme, avec une serie d’experiences faites en presence des commissaires de l’institut national de France, et en divers amphitheatres de Londres. Paris, Fournier, 1804.
Adams R. Cases of diseases of the heart accompanied with pathological observations. Dublin Hosp Rep 1827;4:353–453.
Stokes W. Observations of some cases of permanently slow pulse. Dublin Q J Med Sci 1846;2:73–85.
Duchenne de Bologne GBA. De l’ectrisation localisee et de son application a la pathologie et a la therapeutique par courants induits et par courants galvaniques interrompus et continues. Paris, Bailliere, 1872.
von Ziemssen H. Studien iiber die Bewegungsvorgange am menschlichen Herzen sowie über die mechanische und elektrische Erregbarkeit des Herzens und des Nervus phrenicus, angestellt an dem freiliegenden Herzen der Catharina Serafin. Arch Klin Med 1882;30:270–303.
Hyman AS. Resuscitation of the stopped heart by intracardial therapy. II. Experimental use of an artificial pacemaker. Arch Intern Med 1932;50:283–305.
Zoll PM. Resuscitation of heart in ventricular standstill by external electrical stimulation. N Engl J Med 1952;247:768–771.
Elmquist R, Senning A. An implantable pacemaker for the heart. In: Smyth CN, ed. Medical Electronics. Proceedings of the Second International Conference on Medical Electronics, Paris 1959. London, Iliffe & Sons, 1960.
Furman S, Robinson G. The use of an intracardiac pacemaker in the correction of total heart block. Surg Forum 1958;9:245–248.
Bouvrain Y, Zacouto F. L’entrainment electrosystolique du coeur. Presse Med 1961;69:525–528.
Lown B, Amarasingham R, Neumann J. New method for terminating cardiac arrhythmias. Use of synchronized capacitor discharge. JAMA 1962;182:548–555.
Berkovits B V, Castellanos A Jr, Lemberg L. Bifocal demand pacing. Circulation 1969;40(Suppl):III 44.
Wellens HJJ. Electrical stimulation of the heart in the study and treatment of tachycardias. Leiden, Kroese, 1971.
Zipes DP, Fischer J, King RM, et al. Termination of ventricular fibrillation in dogs by depolarizing a critical amount of myocardium. Am J Cardiol 1975;36:37–44.
Josephson ME, Horowitz LN, Farshidi A, et al. Recurrent sustained ventricular tachycardia. Circulation 1978;57:431–440.
Mirowski M, Reid PR, Mower MM, et al. Termination of malignant ventricular arrhythmias with an implanted automatic defibrillator in human beings. New Engl J Med 1980;303:322–324.
Gallagher JJ, Svenson RH, Kasell JH, et al. Catheter technique for closed-chest ablation of the atrioventricular conduction system: A therapeutic alternative for the treatment of refractory supraventricular tachycardia. N Engl J Med 1982;306:194–200.
Scheinmann MM, Morady F, Hess DS, et al. Transvenous catheter technique for induction of damage to the atrioventricular junction in man. Am J Cardiol 1982;49:1013.
Luderitz B, Naumann d’Alnoncourt C, Steinbeck G, et al. Therapeutic pacing in tachyarrhythmias by implanted pacemakers. PACE 1982;5:366–371.
Manz M, Gerckens U, Luderitz B. Antitachycardia pacemaker (Tachylog) and automatic implantable defibrillator (AID): Combined use in ventricular tachyarrhythmias. Circulation 1985;72(Suppl):III383.
Borggrefe M, Budde T, Podczek A, et al. High frequency alternating current ablation of an accessory pathway in humans. J Am Coll Cardiol 1987;10:576–582.
Saksena S, Parsonnet V. Implantation of a cardioverter-defibrillator without thoracotomy using a triple electrode system. JAMA 1988;259:69–72.
Jackman WM, Wang X, Friday KJ, et al. Catheter ablation of accessory atrioventricular pathways (Wolff-Parkinson-White syndrome) by radiofrequency current. N Engl J Med 1991;324:1605–1611.
Kuck KH, Schluter M, Geiger M, et al. Radiofrequency current catheter ablation of accessory pathways. Lancet 1991;337:1557–1561.
Daubert C, Gras D, Berder V, et al. Permanent atrial resynchronisation by syncronous bi-atrial pacing in the preventive treatment of atrial flutter associated with high degree interatrial block. Arch Mai Coeur Vaiss 1994;11:1535–1546
Cazeau S, Ritter P, Bakdach S, et al. Four chamber pacing in dilated cardiomyopathy. PACE 1994;17:1974–1979.
Lau CP, Tse HF, Lee K, et al. Initial clinical experience of a human implantable atrial defibrillator. PACE 1996; 19:625.
Jung W, Liideritz B. First worldwide implantation of an arrhythmia management system for ventricular and supraventricular tachyarrhythmias. Lancet 1997;349:853–854.
Haissaguerre M, Jais P, Shah DC, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998;339:659–666.
Huang DT, Monahan KM, Zimetbaum P, et al. Hybrid pharmacologic and ablative therapy: a novel and effective approach for the management of atrial fibrillation. J Cardiovasc Electrophysiol 1999;9:462–469.
Waller AG. A demonstration on man of electromotive changes accompanying the heart’s beat. J Physiol 1887;8:229–234.
Einthoven W. Ein neues Galvanometer. Ann Phys 1903;12:1059–1071.
Cremer M. Öber die direkte Ableitung der Aktionsstrome des menschlichen Herzens vom Oesophagus und tiber das Elektrokardiogramm des Fotus. Munch Med Wschr 1906;53:811–813.
Wilson FN, Johnston FD, MacLeod AG, Barker PS. Electrocardiograms that represent the potential variations of a single electrode. Am Heart J. 1933;9:447–458.
Schellong F, Heller S, Schwingel E. Das Vektorkardiogramm, eine Untersuchungsmethode des Herzens. I. Mitteilung Z Kreislaufforsch 1937;29:497.
Nehb W. Zur StandardisierungderBrustwandableitungendesElektrokardiogramms. Klin Wochenschr 1938;17:1807.
Goldberger E. A simple indifferent, electrocardiographic electrode of zero potential and a technique of obtaining augmented unipolar, extremity leads. Am Heart J 1942;23:483–492.
Frank E. An accurate, clinically practical system for spatial vectorcardiography. Circulation 1956;13:737–749.
Giraud G, Puech P, Latour H, Hertault J. Variations de potentiel liees a l’activite du systeme de conduction auricula-ventriculaire chez l’homme. Arch Mal Coeur 1960;53:757–776.
Scherlag BJ, Lau SH, Helfant RH, Berkowitz WD, Stein E, Damato AN. Catheter technique for recording His bundle activity in man. Circulation 1969;39:13–18.
Einthoven W. Öber die Form des menschlichen Elektrocardiogramms. Arch f d Ges Physiol 1895;60:101–123.
Ader C. Sur un nouvel appareil enregistreur pour cables sous-marins. Compt Rend Acad Sci 1897;124:1440–1442.
Einthoven W. Galvanometrische registratie van het menschelijk electrocardiogram. In: Herinnerings-bundel Professor S.S. Rosenstein. Leiden: Eduard Ijdo. 1902:101–107
Einthoven W. Die galvanometrische Registrierung des menschlichen Elektrokardiogramms, zugleich eine Beurteilung der Anwendung des Kapillar-Elektrometers in der Physiologie. Pflugers Arch 1903;99:472–480.
Einthoven W. The string galvanometer and the human electrocardiogram. Proc Kon Akademie voor Wetenschappen 1903;6:107–115.
Einhoven W. Le telecardiogramme. Arch Int de Physiol 1906;4:132–164.
Pardee HEB. Clinical aspects of the electrocardiogram. New York, London, Paul B Hoeber Inc, 1942, pp 32–76.
Liideritz B. Öber die Beziehung zwischen der Breite von QRS und der Form des ST-Stiickes im menschlichen EKG. Arch f Kreislaufforsch 1939;5:223–238.
Forssmann W. Die Sondierung des rechten Herzens. Klin Wochenschr 1929;8:2085–2087.
Scherlag BJ, Lau SH, Helfant RH, et al. Catheter technique for recording His bundle activity in man. Circulation 1969;39:13–18.
Durrer D, Ross JP. Epicardial excitation of the ventricles in a patient with Wolff-Parkinson-White-Syndrome. Circulation 1967;35:15–21.
Wellens HJJ, Schuilenburg RM, Durrer D. Electrical stimulation of the heart in patients with ventricular tachycardia. Circulation 1972;46:216–226.
Gallagher JJ, Pritchett ELC, Sealy WC, et al. The preexcitation syndromes. Prog Cardiovasc Dis 1978;20:285–327.
Horowitz LN, Josephson ME, Farshidi A, et al. Recurrent sustained ventricular tachycardia: role of the electrophysiologic study in selection of antiarrhythmic regimens. Circulation 1978;58:986–997.
Burdon-Sanderson J, Page FJM. On the time-relations of the excitatory process in the ventricle of the heart of the frog. J Physiol 1882;2:385–412.
Schvitz E. Einphasische Aktionsstrome vom in situ durchbluteten Saugetierherzen. Z Biol 1932;92: 441–425.
Franz MR. Monophasic action potentials. Armonk, NY, Futura Publishing Co, 2000, pp 149–363.
Vaughan Williams EM. Classification of antiarrhythmic drugs. In: Sandoe E, Flensted-Jensen E, Olesen KH, eds. Cardiac Arrhythmias. Astra Sodertalje, 1970, pp 449–469.
Gettes LS. The electrophysiologic effects of antiarrhythmic drugs. Am J Cardiol 1971;28:526–535.
Davis LD, Temte JV. Electrophysiological actions of lidocaine on canine ventricular muscle and Purkinje fibers. Circ Res 1969;24:639–655.
Bigger JT, Mandel WJ. Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers. J Clin Invest 1970;49:63–77.
Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. The Sicilian Gambit. Circulation 1991;84:1831–1851.
Luderitz B. Herzrhythmusstorungen. 5. Aufl., Berlin Heidelberg New York, Springer-Verlag, 1998.
Hoff HE. The history of the refractory period: a neglected contribution of Felice Fontana. Yale J Biol Med 1942;14:635–672.
Marey EJ. Des excitations electriques due coeur. Physiologie Experimentale. Travaux du Labaratorie de M Marey. Paris, G. Masson, 1876;2:63–86.
Shapiro E. The electrocardiogram and the arrhythmias: historical insights. In: Mandel WJ, ed. Cardiac Arrhythmias: Their Mechanism, Diagnosis and Management. Philadelphia, J. B. Lippincott, 1980, pp 1–11.
Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 1920;7:353–386.
Shipley RA, Hallaran WR. The four-lead electrocardiogram in two hundred normal men and women. Am Heart J 1936;11:325–329.
Fridericia LS. Die Systolendauer im Elektrokardiogramm bei normalen Menschen und bei Herzkranken. Acta Med Scand 1920;53:469–486.
Ashman R. The normal duration of the QT interval. Am Heart J 1942;23:522–533.
Adams W. The normal duration of the electrocardiographic ventricular complex. J Clin Invest 1936;15:335–342.
Ljung O. A simple formula for clinical interpretation of the QT interval. Acta Med Scand 1949; 134: 79–86.
Schlamowitz I. An analysis of the time relationship within the cardiac cycle in electrocardiograms of normal men. Am Heart J 1946;31:329–342.
Simonson E, Cady LD, Woodbury M. The normal QT interval. Am Heart J 1962:63:747–753.
Gouaux JL, Ashman R. Auricular fibrillation with aberration simulating ventricular paroxysmal tachycardia. Am Heart J 1947;34:366.
Lepeschkin E, Surawicz B. The measurement of the QT interval of the electrocardiogram. Circulation 1952;6:378–388.
Mirvis DM. Spatial variation of QT intervals in normal persons and patients with acute myocardial infarction. J Am Coll Cardiol 1985;5:625–631.
Day CP, McComb JM, Campbell RWF. QT-dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990;63:342–344.
Jackman WM, Friday KJ, Anderson JL, et al. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis 1988;31:118–172.
Roden DM, Spooner PN. Inherited long QT syndrome: aparadigm for understanding arrhythmogenesis. J Cardiovasc Electrophysiol 1999;10:1664–1683.
Jervell A, Lange-Nielsen F. Congenital deaf mutism, functional heart disease with prolongation of the QT interval, and sudden death. Am Heart J 1957;54:59–68.
Romano C, Gemme G, Pongiglione R. Aritmie cardiache rare dell’eta’ pediatrica. Clin Pediatr 1963;45:656–683.
Ward OC. A new familial cardiac syndrome in children. J Irish Med Assoc 1964;54:103–107.
Luderitz B. History of the Disorders of Cardiac Rhythm. Armonk, NY, Futura, 1998.
Dessertenne F. La Tachycardie ventriculaire a deux foyers opposes variables. Arch Mai Couer 1966;59:263–272.
Naumann d’Alnoncourt C, Zierhut W, Luderitz B. “Torsade de pointes” tachycardia: reentry or focal activity? Br Heart J 1982;48:213–216.
Bardy GH, Ungerleider RM, Smith WM, et al. A mechanism of torsades de pointes in a canine model. Circulation 1983;67:52–59.
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Lewalter, T., Lüderitz, B. (2003). Historical Milestones of Electrical Signal Recording and Analysis. In: Gussak, I., Antzelevitch, C., Hammill, S.C., Shen, WK., Bjerregaard, P. (eds) Cardiac Repolarization. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-362-0_2
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