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Essentials of Apoptosis pp 145–161Cite as

Cell Death in Drosophila

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Abstract

Only relatively recently has programmed cell death (PCD) been fully appreciated as a central component of development and disease. Removal of damaged cells represents one of the most important defenses our body has to prevent pathology, and abnormal removal of cells has been observed in a number of degenerative diseases. In this review, we emphasize the importance of cell death during development, with a brief excursion at the end to examine neurodegeneration. The fruitfly Drosophila has been at the center of a number of important discoveries regarding development and signal transduction, so it is perhaps surprising that it has been a relatively late entrant into the world of programmed cell death. However, flies have been making up for lost time.

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Authors
  1. Sujin Bao
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  2. Ross L. Cagan
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Editors and Affiliations

  1. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Xiao-Ming Yin MD, PhD

  2. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA, USA

    Zheng Dong PhD

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Bao, S., Cagan, R.L. (2003). Cell Death in Drosophila . In: Yin, XM., Dong, Z. (eds) Essentials of Apoptosis. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-361-3_10

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  • DOI: https://doi.org/10.1007/978-1-59259-361-3_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5172-7

  • Online ISBN: 978-1-59259-361-3

  • eBook Packages: Springer Book Archive

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