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Genetics and Genomics of Neurobehavioral Disorders pp 3–19Cite as

The Genetics and Genomics of Neurobehavioral Disorders

Historical Introduction and Overview

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Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Broadly speaking, the genetics and genomics of neurobehavioral disorders examine the causal relationship between genetic mutations on the one hand, and impaired development, particularly cognitive—behavioral development, on the other, and the neurobiological and neurophysiological functions that are disrupted in between. Although genetics and genomics form the biological bases of behavior, we do not assume that the biological components are the sole or necessarily the most important contributors to cognitive—behavioral development. During the past century, research by experimental psychologists have clearly demonstrated the extent to which environmental stimuli and the context in which they are presented are salient factors in behavioral growth and development, language, learning, and memory. Humans develop along many psychological dimensions behaviorally, but this text focuses on known genetic anomalies and the cognitive—behavioral deficits that result in difficulties in learning and memory, problem-solving, language, and other associated limitations in psychomotor development. That is not to say no other aspects of behavior may be affected. Various forms of psychopathology may develop concomitantly with many neurodevelopmental genetic abnormalities. Children with the fragile X mutation manifest mild to severe mental retardation, but are also frequently hyperactive, inattentive, and impulsive. Children and adolescents with velo—cardio—facial syndrome develop mild cognitive deficits but an unusually high proportion manifest schizophrenia.

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Authors
  1. Gene S. Fisch
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Editors and Affiliations

  1. Division of Biostatistics, Department of Epidemiology and Public Health and the Child Study Center, Yale University School of Medicine, New Haven, CT, USA

    Gene S. Fisch PhD (Senior Research Scientist) (Senior Research Scientist)

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Fisch, G.S. (2003). The Genetics and Genomics of Neurobehavioral Disorders. In: Fisch, G.S. (eds) Genetics and Genomics of Neurobehavioral Disorders. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-353-8_1

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  • DOI: https://doi.org/10.1007/978-1-59259-353-8_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-322-0

  • Online ISBN: 978-1-59259-353-8

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