Serum Markers for Diagnosis and Risk Stratification in Acute Coronary Syndromes

  • L. Kristin Newby
  • W. Brian Gibler
  • Robert H. Christenson
  • E. Magnus Ohman
Part of the Contemporary Cardiology book series (CONCARD)


Increasingly, both economic and clinical pressures necessitate accurate diagnosis and risk stratification of patients presenting to Emergency Departments (EDs) with suspected or actual acute coronary syndromes. Of the more than 6 million patients who present to EDs in the United States each year for evaluation of chest pain or anginal-equivalent symptoms, only about 15% are identified as having an acute myocardial infarction (MI). Conversely, the conventional evaluation, which includes a history, physical examination, and screening electrocardiogram (ECG) and creatine kinase (CK)-MB, may miss up to 25% of acute MIs at presentation. When unstable angina and nonacute coronary artery disease (CAD) presentations are accounted for, 40% of patients with chest pain do not have an underlying coronary etiology for their symptoms. The challenge is to identify both this group and the group at higher risk as early as possible, to promote rapid treatment of those who may benefit from specific medical or interventional approaches and to avoid costly hospitalization and testing in those at low risk.


Chest Pain Acute Coronary Syndrome Acute Myocardial Infarction Cardiac Troponin Acute Coronary Syndrome Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Humana Press Inc., Totowa, NJ 2003

Authors and Affiliations

  • L. Kristin Newby
  • W. Brian Gibler
  • Robert H. Christenson
  • E. Magnus Ohman

There are no affiliations available

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