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Animal Models of Autoimmune Myocarditis

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Myocarditis

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Abstract

Myocarditis is defined pathologically as an inflammation of the heart muscle. There are 2 major challenges in the field of myocarditis. One is that patients with severe forms of myocarditis die from refractory heart failure because treatment of acute myocarditis is often ineffective. The other is that some of the patients who survive the active phase develop dilated cardiomyopathy. A chronic, autoimmune-mediated myocardial injury is involved in the mechanism of dilated cardiomyopathy. To clarify the pathogenesis of myocarditis and postmyocarditis dilated cardiomyopathy, viral and autoimmune animal models have been developed. In this chapter, we review the models of experimental autoimmune myocarditis (EAM).

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Authors
  1. Makoto Kodama M.D.
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  2. Yuji Okura M.D.
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  3. Yoshifusa Aizawa M.D.
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  4. Tohru Izumi M.D.
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Editor information

Editors and Affiliations

  1. Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA

    Leslie T. Cooper Jr. MD (Consultant, Assistant Professor of Medicine) (Consultant, Assistant Professor of Medicine)

  2. Mayo Medical School, Rochester, Minnesota, USA

    Leslie T. Cooper Jr. MD (Consultant, Assistant Professor of Medicine) (Consultant, Assistant Professor of Medicine)

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© 2003 Springer Science+Business Media New York

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Kodama, M., Okura, Y., Aizawa, Y., Izumi, T. (2003). Animal Models of Autoimmune Myocarditis. In: Cooper, L.T. (eds) Myocarditis. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-319-4_8

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  • DOI: https://doi.org/10.1007/978-1-59259-319-4_8

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-366-4

  • Online ISBN: 978-1-59259-319-4

  • eBook Packages: Springer Book Archive

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