Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment

  • Amato J. Giaccia
Part of the Cancer Drug Discovery and Development book series (CDD&D)


One insight into how oxygen deficiency may affect the aggressiveness of tumors is through the modulation of apoptosis. In experimental tumors, hypoxia can provide a selective pressure for the expansion of populations of oncogenically transformed rodent cells with reduced apoptotic sensitivity, not only to hypoxia (1), but to chemotherapeutic agents as well (2).


Vascular Endothelial Growth Factor Tumor Hypoxia Farnesyltransferase Inhibitor Cervical Epithelial Cell Hypoxia Responsive Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Humana Press Inc., Totowa, NJ 2003

Authors and Affiliations

  • Amato J. Giaccia

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