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Cytokine Gene Polymorphism and Host Susceptibility to Infection

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Cytokines and Chemokines in Infectious Diseases Handbook

Part of the book series: Infectious Disease ((ID))

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Abstract

The individual susceptibility to infection of any organism is determined by a variety of factors such as environmental conditions of the host, pathogenicity of infecting microbes, and the effectiveness of the host’ s defense systems. The induction of specific immune responses such as antibodies released by β-cells and effector T-cells directed against antigens of invading microbes rely on antigen-presenting cells such as macrophages and dendritic cells. These “smart weapons” guarantee the elimination and clearance of antigens and invaders from the body without harming the host’ s own cellular and organ structure and function. In contrast, molecules as part of the evolutionary older innate immune system like defensins or cytokines may prove to be harmful for the host if released in excessive amounts into systemic circulation. On the other hand, low levels of these molecules locally released at the site of infection may result in insufficient clearance of invading microbes.

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  1. Frank Stüber
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Editors and Affiliations

  1. Departments of Surgery and Molecular Sciences, VA Medical Center, University of Tennessee, Memphis, TN, USA

    Malak Kotb PhD

  2. Division of Infectious Diseases, Department of Internal Medicine, Centre Hospital Universitaire Vaudois, Lausanne, Switzerland

    Thierry Calandra MD, PhD

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Stüber, F. (2003). Cytokine Gene Polymorphism and Host Susceptibility to Infection. In: Kotb, M., Calandra, T. (eds) Cytokines and Chemokines in Infectious Diseases Handbook. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-309-5_3

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  • DOI: https://doi.org/10.1007/978-1-59259-309-5_3

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