Abstract
Psychomotor-stimulant drugs such as the amphetamines and cocaine are self-administered by humans and laboratory animals and produce locomotor activation. Repeated exposure to these drugs produces long-term enhancements in their ability to elicit these locomotor responses so that subsequent re-exposure to the drug, weeks to months later, produces greater behavioral activation than seen initially. Most importantly, previous exposure to such sensitizing regimens of amphetamine injections has also been reported to produce long-lasting enhancements in animals’ predisposition to self-administer the drug. The long-term neurobiological changes associated with these enhancements may also figure importantly in the reinstatement of drug taking in individuals that have been drug-free for some time.
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Vezina, P., Suto, N. (2002). Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs. In: Herman, B.H., Frankenheim, J., Litten, R.Z., Sheridan, P.H., Weight, F.F., Zukin, S.R. (eds) Glutamate and Addiction. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-306-4_12
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