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Microbial DNA and Host Immunity pp 203–218Cite as

Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence By Liposomal Delivery

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Abstract

Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotides’ analogs (ISS-ODN or CpG motifs) are potent stimulators of both innate immunity and specific adaptive immune responses (1–5). Bacterial DNA and ISSODNs directly activate monocytes/macrophages, dendritic cells, natural killer (NK) cells and B cells (6–10), induce the production of proinflammatory cytokines (e.g., IL-6, IL-12, IFNs, TNFa) (4,6,7,11,12), and upregulate the expression of MHC I, MHC II and co-stimulatory molecules (9,13). In animal studies, ISS-ODNs exhibit strong Th1 (2,14–18) and mucosal adjuvanticity to a wide range of antigens (2,3,14,19–26) or allergens (27–30). Furthermore, pretreatment with ISS-ODN, even without concomitant administration of the relevant antigens, can afford protection (for about 2 wk) against subsequent infection with intracellular pathogens (31–35), indicating activation of innate immunity.

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Authors
  1. Eli Kedar
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  2. Igal Louria-Hayon
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  3. Aviva Joseph
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  4. Zichria Zakay-Rones
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  5. Tomoko Hayashi
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  6. Kenji Takabayashi
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  7. Yechezkel Barenholz
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Editors and Affiliations

  1. University of California, San Diego, La Jolla, CA, USA

    Eyal Raz MD

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Kedar, E. et al. (2002). Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence By Liposomal Delivery. In: Raz, E. (eds) Microbial DNA and Host Immunity. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-305-7_16

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  • DOI: https://doi.org/10.1007/978-1-59259-305-7_16

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9728-1

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