Abstract
In young life, most typical T cells expressing αβ T-cell receptors (TCR) are naive resting cells and comprise a mixture of CD4+ and CD8+ cells (1,2). These T cells rarely divide in normal unimmunized animals but mount intense TCR-dependent proliferative responses when confronted with specific foreign ligands, i.e., foreign peptides bound to major histocompatibility complex (MHC) molecules on specialized antigen-presenting cells (APC). After eliminating the pathogen concerned, a small proportion of the proliferating T cells survives and forms long-lived memory cells (3–5). These cells are phenotypically distinct from naive T cells. For example, naive T cells express a low density of surface CD44 molecules (CD44lo) whereas memory cells are CD44hi. T cells with a CD44hi memory phenotype comprise only 10–20% of total T cells in young animals but become a predominant population in old age. These “memory-phenotype” cells are considered to be the progeny of naive T cells responding to a variety of environmental antigens.
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References
Sprent, J. (1993) T lymphocytes and the thymus, in Fundamental Immunology, 3rd Edition, (Paul, W. E., ed.), Raven Press, New York, pp. 75–110.
Benoist, C. and Mathis, D. (1999) T-lymphocyte differentiation and biology, in Fundamental Immunology, 4th Edition, (Paul, W. E., ed.), Lippincott-Raven, Philadelphia, pp. 367–409.
Sprent, J. (1993) Lifespans of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5, 433–438.
Dutton, R. W., Bradley, L. M., and Swain, S. L. (1998) T cell memory. Annu. Rev. Immunol 16, 201–223.
Sprent, J. and Surh, C. D. (2000) Generation and maintenance of memory cells. Curr. Opin. Immunol., In press.
Tough, D. F. and Sprent, J. (1994) Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179, 1127–1135.
Tanchot, C., Lemonnier, F. A., Perarnau, B., Freitas, A. A., and Rocha, B. (1997) Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276, 2057–2062.
Rooke, R., Waltzinger, C., Benoist, C., and Mathis, D. (1997) Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity 7, 123–134.
Murali-Krishna, K., Lau, L. L., Sambhara, S., Lemonnier, F., Altman, J., and Ahmed, R. (1999) Persistence of memory CD8 T cells in MHC class I-deficient mice. Science 286, 1377–1381.
Swain, S. L., Hu, H. and Huston, G. (1999) Class II-independent generation of CD4 memory T cells from effectors. Science 286, 1381–1383.
Tough, D. F., Borrow, P. and Sprent, J. (1996) Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272, 1947–1950.
Murali-Krishna, K., Altman, J. D., Suresh, M., et al. (1998) Counting antigenspecific CD8 T cells: A reevaluation of bystander activation during viral infection. Immunity 8, 177–188.
Butz, E. A. and Bevan, M. J. (1998) Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity 8, 167–176.
Andreasen, S. O., Christensen, J. P., Marker, O., and Thomsen, A. R. (1999) Virus-induced non-specific signals cause cell cycle progression of primed CD8(+) T cells but do not induce cell differentiation. Int. Immunol. 11, 1463–1473.
Tough, D. F., Sun, S., and Sprent, J. (1997) T cell stimulation in vivo by lipopolysaccharide (LPS). J. Exp. Med. 185, 2089–2094.
Sprent, J., Zhang, X., Sun, S., and Tough, D. (2000) T cell proliferation in vivo and the role of cytokines. Phil. Trans. R. Roc. Lond. Biol. Sci. 355, 317–322.
Zhang, X., Sun, S., Hwang, I., Tough, D. F., and Sprent, J. (1998) Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8, 591–599.
Sun, S., Zhang, X., Tough, D. F., and Sprent, J. (1998) Type I interferon-mediated stimulation of T cells by CpG DNA. J. Exp. Med. 188, 2335–2342.
Waldmann, T. A. and Tagaya, Y. (1999) The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 17, 19–49.
Nishimura, H., Yajima, T., Naiki, Y., et al. (2000) Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo. J. Exp. Med. 191, 157–170.
Lodolce, J. P., Boone, D. L., Chai, S., et al. (1998) IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9, 669–676.
Kennedy, M. K., Glaccum, M., Brown, S. N., et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191, 771–780.
Ku, C. C., Murakami, M., Sakamoto, A., Kappler, J., and Marrack, P. (2000) Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288, 675–678.
Dai, Z., Konieczny, B. T. and Lakkis, F. G. (2000) The dual role of IL-2 in the generation and maintenance of CD8+ memory T cells. J. Immunol. 165, 3031–3036.
Selin, L. K., Lin, M. Y., Kraemer, K. A., Pardoll, D. M., Schneck, J. P., Varga, S. M., Santolucito, P. A., Pinto, A. K. and Welsh, R. M. (1999) Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. Immunity 11, 733–742.
Busch, D. H., Kerksiek, K. M. and Pamer, E. G. (2000) Differing roles of inflammation and antigen in T cell proliferation and memory generation. J. Immunol. 164, 4063–4070.
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© 2002 Humana Press Inc., Totowa, NJ
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Sprent, J. (2002). IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells. In: Raz, E. (eds) Microbial DNA and Host Immunity. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-305-7_10
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DOI: https://doi.org/10.1007/978-1-59259-305-7_10
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4684-9728-1
Online ISBN: 978-1-59259-305-7
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