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Dietary Supplements pp 321–334Cite as

SAMe (S-adenosyl-l-methionine)

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Part of the book series: Forensic Science and Medicine ((FSM))

Abstract

Because of its instability, SAMe was not investigated as a therapeutic agent until the 1970s, when Stramentinoli and colleagues developed a stable p-toluene-sulfonate complex of SAMe-sulfate (Stramentinoli and Catto, 1976). This preparation was administered parenterally. Its antidepressant effects were first described in 1970 (DeVanna and Rigamoni, 1992). An enteric-coated oral formulation was then developed, but bio-availability was poor, necessitating dosing on the order of 1 g/d compared with several hundred mg/d with the parenteral formulation (Baldessarini, 1987). More stable formulations were subsequently developed (Franzese, 2001). SAMe did not appear on the shelves of retail outlets in the United States until February 1999 (Chamberlain, 2001).

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Authors
  1. Michele Brula
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  2. Melanie Johns Cupp
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  3. Timothy S. Tracy
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Editor information

Editors and Affiliations

  1. West Virginia University, Morgantown, WV, USA

    Melanie Johns Cupp PharmD, BCPS  & Timothy S. Tracy PhD  & 

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Brula, M., Cupp, M.J., Tracy, T.S. (2003). SAMe (S-adenosyl-l-methionine). In: Cupp, M.J., Tracy, T.S. (eds) Dietary Supplements. Forensic Science and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-303-3_21

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  • DOI: https://doi.org/10.1007/978-1-59259-303-3_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9726-7

  • Online ISBN: 978-1-59259-303-3

  • eBook Packages: Springer Book Archive

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