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Toxoplasma gondii

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Opportunistic Infections

Part of the book series: Infectious Disease ((ID))

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Abstract

Toxoplasma is a genus of coccidian protozoa classified into the suborder Eimeriina, order Eucoccidiida, comprising intracellular parasites of many organs and tissues of birds and mammals, including humans. The only known complete hosts of these parasites are cats and other Felidae, in which both asexual and sexual developmental cycles occur in the intestinal epithelium, culminating in the passage of oocysts in the feces. The intestinal stages do not occur in other hosts.

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References

  1. Nguyen, B. T. and Stadtsbaeder, S. Comparative effects of cotrimoxazole (trimethoprim-sulfamethoxazole), pyrimethamine-sulfadiazine and spiramycin during avirulent infection with Toxoplasma gondii (Beverley strain) in mice. Br. J. Pharmacol., 79, 923, 1983.

    Article  PubMed  CAS  Google Scholar 

  2. Renoult, E., Biava, M. F., Hulin, C., Frimat, L., Hestin, D., and Kessler, M. Transmission of toxoplasmosis by renal transplant: a report of four cases. Transplant. Proc., 28, 181, 1996.

    PubMed  CAS  Google Scholar 

  3. Gallino, A., Maggiorini, M., Kiowski, W., et al. Toxoplasmosis in heart transplant recipients. Eur. J. Clin. Microbiol. Infect. Dis., 15, 389, 1996.

    Article  PubMed  CAS  Google Scholar 

  4. Kimball, A. C., Kean, B. H., and Kellner, A. The risk of transmitting toxoplasmosis by blood transfusion. Transfusion, 5, 447, 1965.

    Article  PubMed  CAS  Google Scholar 

  5. Feldman, H. A. Toxoplasmosis. N. Engl. J. Med., 279, 1370, 1968.

    Article  PubMed  CAS  Google Scholar 

  6. Jones, T. C., Kean, B. H., and Kimball, A. C. Acquired toxoplasmosis. NY State J. Med., 69, 2237, 1969.

    CAS  Google Scholar 

  7. Bamford, C. R. Toxoplasmosis mimicking a brain abscess in an adult with treated scleroderma. Neurology, 25, 343, 1975.

    Article  PubMed  CAS  Google Scholar 

  8. Levine, N. D. Protozoan Parasites of Domestic Animals and of Man. Burgess Publishing Co., Minneapolis, 294, 1973.

    Google Scholar 

  9. Feldman, H. A. The clinical manifestations and laboratory diagnosis of toxoplasmosis. J. Trop. Med. Hyg., 2, 420, 1953.

    CAS  Google Scholar 

  10. Feldman, H. A. and Miller, L. T. Congenital human toxoplasmosis. Ann. NYAcad. Sci., 64, 180, 1956.

    Article  Google Scholar 

  11. Conyn-van Spaendonck, M. A., van Knapen, F., and de Jong, P. T. Congenital toxoplasmosis. Tijdschr. Kindergeneeskd., 58, 227, 1990.

    Google Scholar 

  12. Russo, M. and Calanti, B. Prevention of congenital toxoplasmosis. Clin. Ter., 134, 383, 1990.

    PubMed  CAS  Google Scholar 

  13. Couvreur, J., Thulliez, T., Daffos, F., 6 cases of toxoplasmosis in twins. Ann. Pediatr. (Paris), 38, 63, 1991.

    CAS  Google Scholar 

  14. Woods, A.C. Modern concepts of the etiology of uveitis. Am. J. Ophthalmol., 50, 1170, 1960.

    PubMed  CAS  Google Scholar 

  15. O’Connor, G. R. Ocular toxoplasmosis. Jpn. J. Ophthalmol., 19, 1, 1975.

    Google Scholar 

  16. Pivetti-Pezzi, P., Accorinti, M., Tamburi, S., Ciapparoni, V., and Abdulaziz, M. A. Clinical features of toxoplasmic retinochoroiditis in patients with acquired immunodeficiency syndrome. Ann. Ophthalmol., 26, 73, 1994.

    PubMed  CAS  Google Scholar 

  17. Martin-Duverneuil, N., Cordoliani, Y. S., Sola-Martinez, M. T., Miaux, Y., Weill, A., and Chiras, J. Cerebral toxoplasmosis: neuroradiologic diagnosis and prognostic monitoring. J. Neuroradiol., 22, 196, 1995.

    PubMed  CAS  Google Scholar 

  18. Luft, B. J. and Remington, J. S. Toxoplasmic encephalitis. J. Infect. Dis.,157, 1, 1988.

    Google Scholar 

  19. Rostaing, L., Baron, E., Fillola, O., et al. Toxoplasmosis in two renal transplant recipients: diagnosis by bone marrow aspiration. Transplant. Proc., 27, 1733, 1995.

    PubMed  CAS  Google Scholar 

  20. Luft, B. J. and Remington, J. S. Toxoplasmosis of the central nervous system, in Current Clinical Topics in Infectious Diseases, vol. 6, Remington, J. S. and Swartz, M. N., Eds. McGrow-Hill, New York, 315, 1985.

    Google Scholar 

  21. Levy, R. M., Bredersen, D. E., and Rosenblum, M. L. Neurobiological manifestations of the acquired immunodeficiency syndrome (AIDS): experience of UCSF and review of the literature. J. Neurosurg., 621, 475, 1985.

    Google Scholar 

  22. Tuazon, C. U. Toxoplasmosis in AIDS patients. J. Antimicrob. Chemother., 23 (Suppl. A), 77, 1989.

    PubMed  Google Scholar 

  23. Ferrer, S., Fuentes, I., Domingo, P., et al., Cerebral toxoplasmosis in patients with human immunodeficiency virus (HIV) infection: clinico-radiological and therapeutic aspects in 63 patients. Ann. Med. Intl., 13, 4, 1996.

    CAS  Google Scholar 

  24. Winstanley, P. Drug treatment of toxoplasmic encephalitis in acquired immunodeficiency syndrome. Postgrad. Med. J., 71, 404, 1995.

    Article  PubMed  CAS  Google Scholar 

  25. Luft, B. J., Hafner, R., Korzun, A. H., et al. Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med., 329, 995, 1993.

    Article  PubMed  CAS  Google Scholar 

  26. Can, A., Tindall, B., Brew, B. J., et al. Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS, Ann. Intern. Med., 117, 106–111, 1992.

    Google Scholar 

  27. Alappat, J. P., Mathew, C. F., Jayakumar, K., Suresh, I. C., and Kumar, S. A case of cerebral toxoplasmosis. Neurol. India, 48, 185–187, 2000.

    PubMed  CAS  Google Scholar 

  28. Schlager, S. I., Management of opportunistic infections in acquired immunodeficiency syndrome. I. Treatment. Am. J. Ther., 5, 45–49, 1998.

    Article  PubMed  CAS  Google Scholar 

  29. Wilson, C. B., Remington, J. S., Stagno, S., and Reynolds, D. W. Development of adverse sequelae in children born with subclinical congenital Toxoplasma infection. Pediatrics, 66, 767, 1980.

    PubMed  CAS  Google Scholar 

  30. Haverkos, H. W. (coordinator), Assessment of therapy for Toxoplasma encephalitis. The TE Study Group. Am. J. Med., 82, 907, 1987.

    Article  PubMed  CAS  Google Scholar 

  31. Leport, C., Raffi, F., Metherton, S., et al. Treatment of central nervous system toxoplasmosis with pyrimethamine/ sulfadiazine combination in 35 patients with acquired immunodeficiency syndrome: efficacy of long-term continuous therapy. Am. J. Med., 84, 94, 1988.

    Article  PubMed  CAS  Google Scholar 

  32. Post, M. J. D., Kusunoglu, S. J., Hensley, C. T., Chan, J. C., Moskowitz, L. B., and Hoffman, T. A. Cranial CT in acquired immunodeficiency syndrome: spectrum of diseases and optimal contrast enhancement technique. Am. J. Radiol., 145, 929, 1985.

    CAS  Google Scholar 

  33. Tuazon, C. U. Toxoplasmosis in AIDS patients. J. Antimicrob. Chemother., 23 (Suppl. A), 77, 1989.

    PubMed  Google Scholar 

  34. Altes, J, Salas, A., Ricart, C., Villalonga, C., Riera, M., and Casquero, P. Cerebral toxoplasmosis in patients with AIDS. Arch. Neurobiol. (Madr.), 52 (Suppl. 1), 121, 1989.

    Google Scholar 

  35. Carrazana, E. J., Rossitch, E. Jr., and Samuels, M. A. Cerebral toxoplasmosis in the acquired immune deficiency syndrome. Clin. Neurol. Neurosurg., 91, 291, 1989.

    Article  PubMed  CAS  Google Scholar 

  36. Artigas, J., Grosse, G., Niedobitek, F., Kassner, M., Risch, W., and Heise, W., Severe toxoplasmic ventriculomeningoencephalomyelitis in two AIDS patients following treatment of cerebral toxoplasmic granuloma. Clin. Neuropathol., 13, 120, 1994.

    PubMed  CAS  Google Scholar 

  37. Mortier, E., Poirot, J. L., Marteau, M., et al. Pulmonary toxoplasmosis in patients with human immunodeficiency virus infection: 21 cases. Presse Med, 25, 485, 1996.

    CAS  Google Scholar 

  38. Halme, M., Jokipil, L., Jokipil, A. M., Ristola, M., and Landevirta, J. Toxoplasma pneumonia in a patient with AIDS. J. Infect., 31, 252, 1995.

    CAS  Google Scholar 

  39. Gadea, I., Cuenca, M., Benito, N., Pereda, J. M., and Soriano, F. Bronchoalveolar lavage for the diagnosis of disseminated toxoplasmosis in AIDS patients. Diagn. Microbiol. Infect. Dis., 22, 339, 1995.

    Article  PubMed  CAS  Google Scholar 

  40. Knani, L., Bouslama, K., Varette, C., et al. Pulmonary toxoplasmosis in AIDS: report of 3 cases. Ann. Med. Interne (Paris), 141, 469, 1990.

    CAS  Google Scholar 

  41. Miller, R. F., Lucas, S. B., and Bateman, N. T. Disseminated Toxoplasma gondii infection presenting with a fulminant pneumonia. Genitourin. Med., 72, 139, 1996.

    PubMed  CAS  Google Scholar 

  42. Oksenhendler, E., Cadranel, J., Sarfati, C., et al. Toxoplasma gondii pneumonia in patients with the acquired immunodeficiency syndrome. Am. J. Med., 88 (5N), 18N, 1990.

    PubMed  CAS  Google Scholar 

  43. Albrecht, H., Stellbrink, H. J., Fenske, S., Schafer, H., and Greten, H. Successfull treatment of Toxoplasma gondii myocarditis in an AIDS patient. Eur. J. Clin. Microbiol. Infect. Dis., 13, 500, 1994.

    Article  PubMed  CAS  Google Scholar 

  44. Duffield, J. S., Jacob, A. J., and Miller, H. C. Recurrent, life-threatening atrioventricular dissociation associated with Toxoplasma myocarditis. Heart, 76, 453, 1996.

    Article  PubMed  CAS  Google Scholar 

  45. Mastroianni, A., Coronado, O., Scarani, P., Manfredi, R., and Chiodo, F. Liver toxoplasmosis and acquired immunodeficiency syndrome. Recenti Prog. Med., 87, 353, 1996.

    PubMed  CAS  Google Scholar 

  46. Bonacini, M., Kanel, G., and Alamy, M. Duodenal and hepatic toxoplasmosis in a patient with HIV infection: review of the literature. Am. J. Gastroenterol., 91, 1838, 1996.

    PubMed  CAS  Google Scholar 

  47. Kume, H. and Takai, T. Toxoplasmosis of the liver. Ryoikibetsu Shokogun Shirizu, (7), 93, 1995.

    Google Scholar 

  48. Besnier, J. M., Verdier, M., Cotty, F., Fétissof, F., Besancenez, A., and Choutet, P. Toxoplasmosis of the bladder in a patient with AIDS. Clin. Infect. Dis., 21, 452, 1995.

    Article  PubMed  CAS  Google Scholar 

  49. Grassi, M. P., Borella, M., Clerici, F., Perin, C., Bini, M. T., and Mongoni, A. Reversible bilateral opercular syndrome secondary to AIDS-associated cerebral toxoplasmosis. Ital. J. Neurol. Sci., 15, 115, 1994.

    Article  PubMed  CAS  Google Scholar 

  50. Piens, M. A. and Garir, J. P. New perspectives in the chemoprophylaxis of toxoplasmosis. J. Chemother., 1, 46, 1989.

    PubMed  CAS  Google Scholar 

  51. McCabe, R. E. and Oster, S. Current recommendations and future prospects in the treatment of Toxoplasma. Drugs, 38, 973, 1989.

    Article  CAS  Google Scholar 

  52. Georgiev, V. St. Opportunistic/nosocomial infections: treatment and developmental therapeutics. Toxoplasmosis, Med. Res. Rev., 13, 529, 1993.

    Article  Google Scholar 

  53. Georgiev, V. St. Management of toxoplasmosis. Drugs, 48, 179, 1994.

    Article  PubMed  CAS  Google Scholar 

  54. Boyer, K. M. Diagnosis and treatment of congenital toxoplasmosis, Adv. Pediatr. Infect. Dis., 11, 449, 1996.

    PubMed  CAS  Google Scholar 

  55. Behbahani, R., Moshfeghi, M., and Baxter, J. D. Therapeutic approaches for AIDS-related toxoplasmosis. Ann. Pharmacother., 29, 960, 1995 [see comment in Ann. Pharmacother., 29, 1303, 1995 ].

    Google Scholar 

  56. Tomavo, S. and Boothroyd, J. C. (1995) Interconnection between organellar functions, development and drug resistance in the protozoan parasite. Toxoplasma gondii. Int. J. Parasitol., 25, 1293.

    Google Scholar 

  57. Lambotte, R. Toxoplasmose congenitale: evaluation du benefice therapeutique prenatal. J. Gynecol. Obstet. Biol. Reprod. (Paris), 5, 265, 1976.

    CAS  Google Scholar 

  58. Derouin, F., Jacqz-Aigrain, E., Thulliez, P., Couvreur, J., and Leport, C. Cotrimoxazole for prenatal treatment of congenital toxoplasmosis? Parasitol. Today, 16, 254–256, 2000.

    Article  PubMed  CAS  Google Scholar 

  59. Bloch-Michel, E. Ocular toxoplasmosis in 1989. Bull. Soc. Belge Ophthalmol., 230, 53, 1989.

    CAS  Google Scholar 

  60. Finielz, P., Chuet, C., Ramdane, M., and Guiserix, J. Treatment of cerebral toxoplasmosis in AIDS with cotrimoxazole. Presse Med, 24, 917, 1995.

    CAS  Google Scholar 

  61. Holliman, R. E. Folate supplements and the treatment of cerebral toxoplasmosis. Scand. J. Infect. Dis., 21, 475, 1989.

    Article  PubMed  CAS  Google Scholar 

  62. Grange, F., Kinney, E. L., Monsuez, J. J., et al. Successful therapy for Toxoplasma gondii myocarditis in acquired immunodeficiency syndrome. Am. Heart J, 120, 443, 1990.

    Article  PubMed  CAS  Google Scholar 

  63. Gonzalez-Clemente, J. M., Miró, J. M., Pedrol, E., Encephalic toxoplasmosis in patients with acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases. Med. Clin. (Barcelona), 95, 441, 1990.

    Google Scholar 

  64. Podamczer, D., Miró, J. M., Ferrer, E., Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group. Eur. J. Clin. Microbiol. Infect. Dis., 19, 89–95, 2000.

    Google Scholar 

  65. Podzamczer, D., Miró, J. M., Ferrer, E., and Gatell, J. M. Thrice-weekly vs. daily sulfadiazine-pyrimethamine (SP) for maintenance therapy of toxoplasmic encephalitis (TE). 5th Conf. Retroviral Opportunistic Infect., Feb. 1–5, 167, abstract 468, 1998.

    Google Scholar 

  66. Holliman, R. E. Clinical and diagnostic findings in 20 patients with toxoplasmosis and acquired immune deficiency syndrome. J. Med. Microbiol., 35, 1, 1991.

    Article  PubMed  CAS  Google Scholar 

  67. Wanke, C., Tuazon, C. U., Kovacs, A., Toxoplasma encephalitis in patients with acquired immune deficiency syndrome: diagnosis and response to therapy. Am. J. Trop. Med. Hyg., 36, 509, 1987.

    Google Scholar 

  68. Cimino, C., Lipton, R. B., Williams, A., Feraru, E., Harris, C., and Hirschfeld, A. The evaluation of patients with human immunodeficiency virus-related disorders and brain mass lesions. Arch. Intern. Med., 151, 1381, 1991.

    Google Scholar 

  69. Langmann, P., Klinker, H., and Richter, E. Pyrimethamine-sulphadiazine resistant cerebral toxoplasmosis in AIDS. Dtsch. Med. Wochenschr.120, 780, 1995

    Google Scholar 

  70. Huber, W., Bautz, W., Classen, M., and Schepp, W. Pyrimethamine-sulfadiazine resistant cerebral toxoplasmosis in AIDS. Dtsch. Med. Wochenschr., 120, 60, 1995.

    Article  PubMed  CAS  Google Scholar 

  71. Luft, B. J., Brooks, R. G., Conley, P. K., McCabe, R. E., and Remington, J. S. Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome. J. Am. Med. Assoc., 252, 913, 1984.

    Article  CAS  Google Scholar 

  72. Bell, E. T., Tapper, M. L., and Pollock, A. A. Sulphadiazine desensitization in AIDS patients. Lancet, 1, 163, 1985.

    Article  PubMed  CAS  Google Scholar 

  73. Tenant-Flowers, M., Boyle, M. J., Carey, D., et al. Sulphadiazine desensitization in patients with AIDS and cerebral toxoplasmosis. AIDS, 5, 311, 1991.

    Article  PubMed  CAS  Google Scholar 

  74. Gilquin, J., Magar, Y., Acar, J. F., and Blamontier, J. Induction de tolerance a la sulfadiazine chez un malade atteint de syndrome d’immunodeficit acquit. Presse Med, 17, 2306, 1988.

    CAS  Google Scholar 

  75. Leport, C., Tournerie, C., Raguin, G., Fernandez-Martin, J., Niyongabo, T., and Vildé, J.-L. Long-term follow-up of patients with AIDS on maintenance therapy for toxoplasmosis. Eur. J. Clin. Microbiol. Infect. Dis., 10, 191, 1991.

    Article  PubMed  CAS  Google Scholar 

  76. Pedro!, E., Gonzalez-Clemente, J. M., GateIl, J. M., et al. Central nervous system toxoplasmosis in AIDS patients: efficacy of an intermittent maintenance therapy. AIDS, 4, 511, 1990.

    Article  Google Scholar 

  77. Bhatti, N. and Larson, E. Low-dose alternate-day pyrimethamine for maintenance therapy in cerebral toxoplasmosis complicating AIDS. J. Infect., 21, 119, 1990.

    Article  PubMed  CAS  Google Scholar 

  78. Heald, A., Flepp, J. M., Chave, J. P., et al. Treatment for cerebral toxoplasmosis protects against Pneumocystis carinii pneumonia in patients with AIDS. Ann. Intern. Med., 115, 760, 1991.

    PubMed  CAS  Google Scholar 

  79. Michalova, K., Rihova, E., and Havlikova, M. Fansidar in the treatment of toxoplasmosis. Cesk. Slov. Oftalmol., 52, 173, 1996.

    PubMed  CAS  Google Scholar 

  80. Harland, C. C., Marsden, J.R., Vernon, S. A., and Allen, B. R. Dermatomyositis responding to treatment of associated toxoplasmosis. Br. J. Dermatol., 125, 76, 1991.

    Article  PubMed  CAS  Google Scholar 

  81. Couvreur, J., In utero treatment of congenital toxoplasmosis with a pyrimethamine-sulfadiazine combination. Presse Med, 20, 1136, 1991.

    Google Scholar 

  82. Couvreur, J., Thulliez, P., Daffos, F., et al. Fetal toxoplasmosis: in utero treatment with pyrimethamine sulfamides. Arch. Fr. Pediatr., 48, 397, 1991.

    PubMed  CAS  Google Scholar 

  83. Boulot, P., Pratlong, F., Sarda, P., et al. Limitations of prenatal treatment of congenital toxoplasmosis with a sulfadiazine-pyrimethamine combination. Presse Med, 31, 570, 1990.

    Google Scholar 

  84. Dorangeon, P., Fay, R., Marx-Chemba, C., et al. Transplacental passage of the pyrimethamine-sulfadoxine combination in the prenatal treatment of congenital toxoplasmosis. Presse Med, 19, 2036, 1990.

    CAS  Google Scholar 

  85. Cottrell, A. J. Acquired Toxoplasma encephalitis. Arch. Dis. Child., 61, 84, 1986.

    Article  PubMed  CAS  Google Scholar 

  86. Sabin, A. B. Toxoplasmic encephalitis in children. J. Am. Med. Assoc., 116, 801, 1941.

    Article  Google Scholar 

  87. Rose, M. S., Black, P. J., and Barkhan, P. Fatal outcome after combined therapy for myeloblastic leukaemia and toxoplasmosis. Lancet, 1, 600, 1973.

    Article  PubMed  CAS  Google Scholar 

  88. Price, I. A., Bondy, P. K., and Ferench, G. E. Fatal outcome after combined therapy for myeloblastic leukaemia and toxoplasmosis. Lancet, 1, 727, 1973.

    Article  Google Scholar 

  89. Bruce, W. R., Meeker, B. E., and Valeriote, F. A. Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo. J. Natl. Cancer Inst., 37, 233, 1966.

    PubMed  CAS  Google Scholar 

  90. Valeriote, F. A. and Bruce, W. R. Comparison of the sensitivity of hematopoietic colony-forming cells in different proliferative states to vinblastine. J. Natl. Cancer Inst., 38, 393, 1967.

    PubMed  CAS  Google Scholar 

  91. Bruce, W. R. and Meeker, B. E. Comparison of the sensitivity of hematopoietic colony-forming cells in different proliferative states to 5-fluorouracil. J. Natl. Cancer Inst., 38, 401, 1967.

    PubMed  CAS  Google Scholar 

  92. Opravil, M., Keusch, G., and Luthy, R. Pyrimethamine inhibits renal secretion of creatinine. Antimicrob. Agents Chemother., 37, 1056, 1993.

    Article  PubMed  CAS  Google Scholar 

  93. Simon, D. I., Brosius III, F. C., and Rothstein, D. M. Sulfadiazine crystalluria revisited: the treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. Arch. Intern. Med., 150, 2379, 1990.

    CAS  Google Scholar 

  94. Diaz, F., Collazos, J., Mayo, J., and Martinez, E., Sulfadiazine-induced multiple urolithiasis and acute renal failure in a patient with AIDS and Toxoplasma encephalitis. Ann. Pharmacother., 30, 41, 1996.

    PubMed  CAS  Google Scholar 

  95. Rodriguez-Carballeira, M., Casagran, A., More, J., Argilaga, R., and Garcia, M. Acute renal insufficiency caused by sulfadiazine in a patient with cerebral toxoplasmosis and AIDS. Enferm. Infecc. Microbiol. Clin., 14, 125, 1996.

    PubMed  CAS  Google Scholar 

  96. Becker, K., Jablonowski, H., and Haussinger, D. Sulfadiazine-associated nephrotoxicity in patients with the acquired immunodeficiency syndrome. Medicine (Baltimore), 75, 185, 1996.

    Article  CAS  Google Scholar 

  97. Peh, C. A., Kimber, T. E., Shaw, D. R., and Clarkson, A. R. Acute renal failure due to sulphadiazine in a patient with acquired immunodeficiency syndrome (AIDS). Aust. N. Z. J. Med., 25, 58, 1995.

    Article  PubMed  CAS  Google Scholar 

  98. Potter, J. L. and Kofron, W. G. Sulfadiazine/N4-acetylsulfadiazine crystalluria in a patient with the acquired immune deficiency syndrome (AIDS). Clin. Chim. Acta, 230, 221, 1994.

    Article  PubMed  CAS  Google Scholar 

  99. Bressollette, L., Carlhant, D., Bellein, V., Morand, C., Mottier, D., and Riche, C. Crystalluria induced by sulfadiazine in an AIDS patient. Therapy, 49, 154, 1994.

    CAS  Google Scholar 

  100. Furrer, H., von Overbeck, J., Jaeger, P., and Hess, B. Sulfadiazine nephrolithiasis and nephropathy. Schweiz. Med. Wochenschr., 124, 2100, 1994.

    PubMed  CAS  Google Scholar 

  101. Marques, L. P., Madeira, E. P., and Santos, O. R. Renal alterations induced by sulfadiazine therapy in an AIDS patient. Clin. Nephrol., 42, 68, 1994 [see comments in Clin. Nephrol., 39, 254, 1993 ].

    Google Scholar 

  102. Kronawitter, U., Jacob, K., Zoller, W. G., Rauh, G., and Goebel, F. D. Acute kidney failure caused by sulfadiazine stones: a complication of the therapy of toxoplasmosis in AIDS. Dtsch. Med. Wochenschr., 118, 1683, 1993.

    Article  PubMed  CAS  Google Scholar 

  103. Hein, R., Brunkhorst, R., Thon, W. F., Schedel, I., and Schmidt, R. E. Symptomatic sulfadiazine crystalluria in AIDS patients: a report of two cases. Clin. Nephrol., 39, 254, 1993 [see comments in Clin. Nephrol., 42, 68, 1994 ].

    Google Scholar 

  104. Farinas, M. C., Echevarria, S., Sampedro, I., et al. Renal failure due to sulphadiazine in AIDS patients with cerebral toxoplasmosis. J. Intern. Med., 233, 365, 1993.

    Article  PubMed  CAS  Google Scholar 

  105. Diaz, F., Collazos, J., Mayo, J., and Martinez, E. Sulfadiazine-induced multiple urolithiasis and acute renal failure in a patient with AIDS and Toxoplasma encephalitis. Ann. Pharmacother., 30, 41, 1996.

    PubMed  CAS  Google Scholar 

  106. Carbone, L. G., Bendixen, B., and Appel, G. B. Sulfadiazine-associated obstructive nephropathy occuring in a patient with the acquired immunodeficiency syndrome. Am. J. Kidney Dis., 12, 72, 1988.

    PubMed  CAS  Google Scholar 

  107. Molina, J. M., Belefant, X., Doco-Lacompte, T., Idatte, J. M., and Modai, J., Sulfadiazine induced crystalluria in AIDS patients with Toxoplasma encephalitis. AIDS, 5, 587, 1991.

    Article  PubMed  CAS  Google Scholar 

  108. Oster, S., Hutchinson, F., and McCabe, R. Resolution of acute renal failure in toxoplasmic encephalitis despite continuance of sulfadiazine. Rev. Infect. Dis., 12, 618, 1990.

    Article  PubMed  CAS  Google Scholar 

  109. Caumes, E., Bocquet, H., Guermonprez, G., et al. Adverse cutaneous reactions to pyrimethamine/sulfadiazine and pyrimethamine/clindamycin in patients with AIDS and toxoplasmic encephalitis. Clin. Infect. Dis., 21, 656, 1995.

    Article  PubMed  CAS  Google Scholar 

  110. Lafrenz, M., Ziegler, K., Saender, R., Budde, E., and Naumann, G. Treatment of toxoplasmosis. Muenchen. Med. Wochenschr., 115, 2057, 1973.

    CAS  Google Scholar 

  111. Norrby, R., Eilard, T., Svedhen, A., and Lycke, E. Treatment of toxoplasmosis with trimethoprim-sulphamethoxazole. Scand. J. Infect. Dis., 7, 72, 1975.

    PubMed  CAS  Google Scholar 

  112. Norrby, R. and Eilard, T. Recurrent toxoplasmosis. Scand. J. Infect. Dis., 8, 275, 1976.

    PubMed  CAS  Google Scholar 

  113. Burchall, J. J. Mechanism of action of trimethoprim-sulfamethoxazole. II. J. Infect. Dis., 128 (suppl.-Nov), S473, 1973.

    Google Scholar 

  114. Greenlee, J. E., Johnson, W. D. Jr., Campa, J. F., Adelman, L. S., and Sande, M. A. Adult cerebellar ataxia. Ann. Intern. Med., 82, 367, 1975.

    PubMed  CAS  Google Scholar 

  115. Williams, M. and Savage, D. C.L. Acquired toxoplasmosis in children. Arch. Dis. Child., 53, 829, 1978.

    Article  PubMed  CAS  Google Scholar 

  116. Remington, J. S. Acquired toxoplasmosis in children. Arch. Dis. Child., 55, 80, 1980.

    Article  PubMed  CAS  Google Scholar 

  117. Esposito, R., Lazzarin, A., Orlando, G., Gallo, M., and Foppa, C. U. ABC of AIDS: treatment of infections and antiviral agents. Br. Med. J. (Clin. Res.), 295, 668, 1987.

    Article  Google Scholar 

  118. Solbreux, P., Sonnet, J., and Zech, F. A retrospective study about the use of cotrimoxazole as diagnostic support and treatment of suspected cerebral toxoplasmosis in AIDS. Acta Clin. Belg., 45, 85, 1990.

    PubMed  CAS  Google Scholar 

  119. Jick, H. Adverse reactions to trimethoprim-sulfamethoxazole in hospitalized patients. Rev. Infect. Dis., 4, 426, 1982.

    Article  PubMed  CAS  Google Scholar 

  120. Desmonts, G. and Couvreur, J. Congenital toxoplasmosis: a prospective study of the offspring of 542 women who acquired toxoplasmosis during pregnancy. Pathophysiology of congenital disease, in Proc. 6th European Congr. Perinat. Med., Vienna, Thalhammer, O., Baumgarten, K., and Polak, A., Eds. Georg Thieme, Stuttgart, 51, 1979.

    Google Scholar 

  121. Chang, H. R. and Pechère, J. C. Activity of spiramycin against Toxoplasma gondii in vitro, in experimental infections and in human infection. J. Antimicrob. Chemother., 22 (Suppl.), 87, 1988.

    Article  PubMed  CAS  Google Scholar 

  122. Martin, C. and Mahon, R. Traitment de la toxoplasmose. Nouv. Presse Med., 2, 2202, 1974.

    Google Scholar 

  123. Desmonts, G. and Couvreur, J. Congenital toxoplasmosis: a prospective study of 378 pregnancies. N. Engl. J. Med., 290, 1110, 1974.

    Article  PubMed  CAS  Google Scholar 

  124. Desmonts, G., Couvreur, J., and Thulliez, P. Prophylaxis of congenital toxoplasmosis: effects of spiramycin on placental injection. J. Antimicrob. Chemother., 22 (Suppl.), 193, 1988.

    Article  PubMed  Google Scholar 

  125. Fortier, B., Ajana, F., Pinto de Sousa, M. I., Aissi, E., and Camus, D. Prevention and treatment of materno-fetal toxoplasmosis. Presse Med, 20, 1374, 1991.

    CAS  Google Scholar 

  126. Koppe, J. G., Loewer-Siegler, D. H., and De Roever-Bonnet, H. Results of 20-year follow-up of congenital toxoplasmosis. Lancet, 1, 254, 1986.

    Article  PubMed  CAS  Google Scholar 

  127. Hohfeld, P., Daffos, F., Thilliez, P., et al. Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment. J. Pediatr., 115, 765, 1989.

    Article  Google Scholar 

  128. Chodos, J. B. and Habegger-Chodos, H. E. The treatment of ocular toxoplasmosis with spiramycin. Arch. Ophthalmol., 65, 401, 1961.

    Article  PubMed  CAS  Google Scholar 

  129. Fajardo, R. V., Furguiele, F. P., and Leopold, J. M. Treatment of toxoplasmosis uveitis. Arch. Ophthalmol., 67, 712, 1962.

    Article  PubMed  CAS  Google Scholar 

  130. Cassidy, J. V., Bahler, J. W., and Minken, M. V. Spiramycin for toxoplasmosis. Am. J. Ophthalmol., 57, 227, 1964.

    Google Scholar 

  131. Canamucio, C. J., Hallet, J. W., and Leopold, J. M. Recurrence of treated toxoplasmic uveitis. Am. J. Ophthalmol., 55, 1035, 1963.

    PubMed  CAS  Google Scholar 

  132. Timsit, J. C. and Bloch-Michel, E. Efficacite de la chimiotherapie specifique dans la prevention des recidives des chorioretinitis toxoplasmiques dans les quatre annees qui suivent la traitment. J. Fr. Ophthalmol., 10, 15, 1987.

    CAS  Google Scholar 

  133. Descotes, J., Vial, T., Delattre, D., and Evreux, J. C. Spiramycin: safety in man. Antimicrob. Agents Chemother., 22 (Suppl. B), 207, 1988.

    Article  Google Scholar 

  134. Ostlere, L. S., Langtry, J. A., and Staughton, R. C. Allergy to spiramycin during prophylactic treatment of fetal toxoplasmosis. Br. Med. J., 302, 970, 1991.

    Article  CAS  Google Scholar 

  135. Kawakami, Y., Hayashi, J., Fujisaki, T., et al., A case of toxoplasmosis with dermatomyositis. Kansenshogaku Zasshi, 69, 1312, 1995.

    PubMed  CAS  Google Scholar 

  136. Burke, G. J. and Mills, A. F. Toxoplasmosis and clindamycin. S. Afr. Med. J., 55, 156, 1979.

    PubMed  CAS  Google Scholar 

  137. Dannemann, B. R., Israelski, D. M., and Remington, J. S. Treatment of toxoplasmic encephalitis with intravenous clindamycin. Arch. Intern. Med., 148, 2477, 1988.

    Article  PubMed  CAS  Google Scholar 

  138. Remington, J. S. and Vildé, J.-L., Clindamycin for Toxoplasma encephalitis in AIDS. Lancet, 338, 1142, 1991.

    Article  PubMed  CAS  Google Scholar 

  139. Santos Gil, I., Noguerado Asensio, A., del Arco Galan, C., and Garcia Polo, I. Clindamycin in the treatment of cerebral toxoplasmosis in a patient with AIDS. Rev. Clin. Esp., 185, 47, 1989.

    Google Scholar 

  140. Westblom, T. U. and Belshe, R. B. Clindamycin therapy of cerebral toxoplasmosis in an AIDS patient. Scand. J. Infect. Dis., 20, 561, 1988.

    Article  PubMed  CAS  Google Scholar 

  141. Goldsmith, J. M. Toxoplasmosis and clindamycin. S. Afr. Med. J., 57, 37, 1980.

    Google Scholar 

  142. Marcos, C., Sopena, B., Luna, I., Gonzalez, R., de la Fuente, J., and Martinez-Vazquez, C. Clindamycin desensitization in an AIDS patient. AIDS, 9, 1201, 1995.

    Article  PubMed  CAS  Google Scholar 

  143. Rolston, K. V. I., Clindamycin in cerebral toxoplasmosis, Am. J. Med., 85, 254, 1988.

    Google Scholar 

  144. Rolston, K. V. Treatment of acute toxoplasmosis with oral clindamycin. Eur. J. Clin. Microbiol. Infect. Dis., 10, 181, 1991.

    Article  PubMed  CAS  Google Scholar 

  145. Podzamczer, D. and Gudiol, F. Clindamycin in cerebral toxoplasmosis. Am. J. Med., 84, 800, 1988.

    Article  CAS  Google Scholar 

  146. Kaplan, L., Wofsy, C., and Volberding, P. Treatment of patients with acquired immune deficiency syndrome and associated manifestations. J. Am. Med. Assoc., 257, 1374, 1987.

    Google Scholar 

  147. Rolston, K. V. I. and Hoy, J. Role of clindamycin in the treatment of central nervous system toxoplasmosis. Am. J. Med., 83, 551, 1987.

    Article  CAS  Google Scholar 

  148. Ruf, B. and Pohle, H. D. Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system. Eur. J. Clin. Microbiol. Infect. Dis., 10, 183, 1991.

    Article  PubMed  CAS  Google Scholar 

  149. Dannemann, B. R., McCutchan. J. A., Israelski, D. M., Treatment of acute toxoplasmosis with intravenous clindamycin, Eur. J. Clin. Microbiol. Infect. Dis., 10, 193, 1991.

    Google Scholar 

  150. Dannemann, B., MacCutchan, J. A., Israelski, D., et al. Treatment of toxoplasmic encephalitis in patients with AIDS: a randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. Ann. Intern. Med., 116, 33, 1992.

    PubMed  CAS  Google Scholar 

  151. Katlama, C. Evaluation of the efficacy and safety of clindamycin plus pyrimethamine for induction and maintenance therapy of toxoplasmic encephalitis in AIDS. Eur. J. Clin. Microbiol. Infect. Dis., 10, 189, 1991.

    Article  PubMed  CAS  Google Scholar 

  152. Foppa, C. U., Bini, T., Gregis, G., Lazzarin, A., Esposito, R., and Moroni, M. A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine. Eur. J. Clin. Microbiol. Infect. Dis., 10, 187, 1991.

    Article  PubMed  CAS  Google Scholar 

  153. Leport, C., Bastuji-Garin, S., Perronne, C., et al. An open study of the pyrimethamine-clindamycin combination in AIDS patients with brain toxoplasmosis. J. Infect. Dis., 160, 557, 1989.

    Article  PubMed  CAS  Google Scholar 

  154. Cohn, J. A., McMeeking, A., Cohen, W., Jacobs, J., and Holzman, R. S., Evaluation of the policy of empiric treatment of suspected Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. Am. J. Med., 86, 521, 1989.

    Article  PubMed  CAS  Google Scholar 

  155. Dhiver, C., Milandre, C., Poizot-Martin, I., Drogoul, M. P., Gastaut, J. L., and Gastaut, J. A., 5-Fluorouracil-clindamycin for treatment of cerebral toxoplasmosis. AIDS, 7, 143, 1993.

    Article  PubMed  CAS  Google Scholar 

  156. Dalston, M. O., Tavares, W., Bazin, A. R., Hahn, Clarithromycin combined with pyrimethamine in cerebral toxoplasmosis: a report of 2 cases. Rev. Soc. Bras. Med. Trop., 28, 409, 1995.

    Google Scholar 

  157. Lacassin, F., Schaffo, D., Perronne, C., Longuet, P., Leport, C., and Vildé, J.-L. Clarithromycin-minocycline combination as salvage therapy for toxoplasmosis in patients infected with human immunodeficiency virus. Antimicrob. Agents Chemother., 39, 276, 1995.

    Article  PubMed  CAS  Google Scholar 

  158. Sellai, A., Rabaud, C., Amiel, C., Hoen, B., May, T., and Canton, Ph. Maintenance treatment of cerebral toxoplasmosis in AIDS: role of clarithromycin-minocycline combination. Presse Med, 25, 509, 1996.

    Google Scholar 

  159. Alba, D., Molina, F., Ripoli, M. M., and del Arco, A. Clarithromycin in the treatment of cerebral toxoplasmosis associated with HIV infection. Rev. Clin. Esp., 192, 458, 1993.

    PubMed  CAS  Google Scholar 

  160. Saba, J., Morlat, P., Raffi, F., et al. Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS. Eur. J. Clin. Microbiol. Infect. Dis., 12, 853, 1993.

    Article  PubMed  CAS  Google Scholar 

  161. Godofsky, E. W. Treatment of presumed cerebral toxoplasmosis with azithromycin. N. Engl. J. Med., 330, 575, 1994.

    Article  PubMed  CAS  Google Scholar 

  162. Valencia, M. E., Laguna, F., Soriano, V., and Gonzalez Lahoz, J. Favorable course of cerebral toxoplasmosis treated with doxycycline and pyrimetamine. Rev. Clin. Esp., 192, 197, 1993.

    PubMed  CAS  Google Scholar 

  163. Hagberg, L., Palmertz, B., and Lindberg, J. Doxycycline and pyrimethamine for toxoplasmic encephalitis. Scand. J. Infect. Dis., 25, 157, 1993.

    PubMed  CAS  Google Scholar 

  164. Clumeck, N., Katlama, C., Ferrero, T., et al., Atovaquone (l,4-hydroxynaphthoquinone, 566C80) in the treatment of acute cerebral toxoplasmosis (CT) in AIDS patients. 32nd Intersci. Conf Antimicrob. Agents Chemother., American Society for Microbiology, Washington, DC, abstract 1217, 1992.

    Google Scholar 

  165. Grundman, M., Torres, R. A., Thorn, M., Hriso, and Britton, D. Neuroradiologic response to 566C80 salvage therapy for CNS toxoplasmosis. Proc. Vllth Int. Conf. AIDS,Amsterdam, 1992, abstract PoB 3185.

    Google Scholar 

  166. Kovacs, J. A. NIAID-Clinical CIAIDSP: efficacy of atovaquone in treatment of toxoplasmosis in patients with AIDS. Lancet, 340, 637, 1992.

    Article  PubMed  CAS  Google Scholar 

  167. Lafeuillade, A., Pellegrino, P., Poggi, C., et al. Efficacité de l’atovaquone dans les toxoplasmoses résistantes du SIDA. Presse Med, 22, 1708, 1993.

    CAS  Google Scholar 

  168. Spencer, C. M. and Goa, K. L. Atovaquone: a review of its pharmacological properties and therapeutic efficacy in opportunistic infections. Drugs, 50, 176, 1995.

    Article  PubMed  CAS  Google Scholar 

  169. Bouboulis, D. A., Rubinstein, A., Shliozberg, J., Madden, J., and Frieri, M. Cerebral toxoplasmosis in childhood and adult HIV infection treated with 1,4-hydroxynaphthoquinone and rapid desensitization with pyrimethamine. Ann. Allergy Asthma Immunol, 74, 491, 1995.

    PubMed  CAS  Google Scholar 

  170. Schimkat, M., Althaus, C., Armbrecht, C., Jablonowski, H., and Sundmacher, R. Treatment of toxoplasmosis retinochoroiditis with atovaquone in an AIDS patient. Klin. Monatsbl. Augenheilkd., 206, 173, 1995.

    Article  PubMed  CAS  Google Scholar 

  171. Durand, J. M., Cretel, E., Bagneres, D., Guillemot, E., Kaplanski, G., and Soubeyrand, J. Failure of atovaquone in the treatment of cerebral toxoplasmosis. AIDS, 9, 812, 1995.

    Article  PubMed  CAS  Google Scholar 

  172. Katlama, C., Mouthon, B., Gourdon, D., Lapierre, D., and Rousseau, F. Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. AIDS, 10, 1107, 1996.

    Article  PubMed  CAS  Google Scholar 

  173. Masur, H., Polis, M. A., Tuazon, C. U., et al. Salvage trial of trimetrexate-leucovorin for the treatment of cerebral toxoplasmosis in patients with AIDS. J. Infect. Dis., 167, 1422, 1993.

    Article  PubMed  CAS  Google Scholar 

  174. Tabbara, K. F. Ocular toxoplasmosis: toxoplasmic retinochoroiditis. Int. Ophthalmol. Clin., 35, 15, 1995.

    Article  PubMed  CAS  Google Scholar 

  175. Chakroun, M., Meyohas, M. C., Pelosse, B., et al. Ocular toxoplasmosis in AIDS. Ann. Med. Interne (Paris), 141, 472, 1990.

    CAS  Google Scholar 

  176. Blanc-Jouvan M., Boibieux, A., Fleury, J., et al. Chorioretinitis following liver transplantation: detection of Toxoplasma gondii in aqueous humor. Clin. Infect. Dis., 22, 184, 1996.

    Article  PubMed  CAS  Google Scholar 

  177. Peacock, J. E. Jr., Greven, C. M., Cruz, J. M., and Hurd, D. D. Reactivation of toxoplasmic retinochoroiditis in patients undergoing bone marrow transplantation: is there a role for chemoprophylaxis? Bone Marrow Transplant, 15, 983, 1995.

    Google Scholar 

  178. Engstrom, R. E. Jr., Holland, G. N., Nussenblatt, R. B., and Jabs, D. A. Current practices in the management of ocular toxoplasmosis. Am. J. Ophthalmol., 111, 601, 1991.

    Google Scholar 

  179. Ronday, M. J., Luyendijk, L., Baarsma, G. S., Bollemeijer, J. G., Van der Lelij, A., and Rothova, A. Presumed acquired ocular toxoplasmosis. Arch. Ophthalmol., 113, 1524, 1995.

    Article  PubMed  CAS  Google Scholar 

  180. Mittelviefhaus, H. Treatment of ocular toxoplasmosis. Part 2: therapeutic approaches. Kinderarztl. Prax., 61, 154, 1993.

    Google Scholar 

  181. Mittelviefhaus, H. Treatment of ocular toxoplasmosis. Part 1: basic principles and diagnosis. Kinderarztl. Prax., 61, 90, 1993.

    Google Scholar 

  182. Rothova, A. Ocular involvement in toxoplasmosis. Br. J. Ophthalmol., 77, 371, 1993 [correction in Br. J. Ophthalmol., 77, 683, 1993 ].

    Article  Google Scholar 

  183. Rothova, A., Meenken, C., Buitenhuis, H. J., et al. Therapy of ocular toxoplasmosis. Am. J. Ophthalmol., 115, 517, 1993.

    PubMed  CAS  Google Scholar 

  184. Psilas, K., Petroutsos, G., and Aspiotis, M. Treatment of toxoplasmosis. J. Fr. Ophthalmol., 13, 551, 1990.

    CAS  Google Scholar 

  185. Lebech, A. M., Lebech, M., Borme, K. K., and Mathiesen, L. R. Toxoplasmosis-chorioretinitis: clinical course and treatment of seven patients. Ugeskr. Laeger, 158, 3935, 1996.

    PubMed  CAS  Google Scholar 

  186. Holland, G. N. and Lewis, K. G. An update on current practices in the management of ocular toxoplasmosis. Am. J. Opthamol., 134, 102–114, 2002.

    Article  Google Scholar 

  187. Lam, S. and Tessler, H. H. Quadruple therapy for ocular toxoplasmosis. Can. J. Ophthalmol., 28, 58, 1993.

    PubMed  CAS  Google Scholar 

  188. Rothova, A., Buitenhuls, H. J., Meenken, C., et al. Therapy of ocular toxoplasmosis. Int. Ophthalmol., 13, 415, 1989.

    Article  PubMed  CAS  Google Scholar 

  189. Colin, J. and Harie, J. C. Presumed toxoplasmic chorioretinitis: comparative study of treatment with pyrimethamine and sulfadiazine or clindamycin. J. Fr. Ophthalmol., 12, 161, 1989.

    CAS  Google Scholar 

  190. Hansen, L. L., Nieuwenhuis, I., Hoeffken, G., and Heise, W. Retinitis in AIDS patients: diagnosis, follow-up and treatment. Fortschr. Ophthalmol., 86, 232, 1988.

    Google Scholar 

  191. Theodossiadis, G. P., Koutsandrea C., and Tzonou, A. A comparative study concerning the treatment of active toxoplasmic retinochoroiditis with argon laser and medication (follow-up 2–9 years). Ophthalmologica, 199, 77, 1989.

    Article  PubMed  CAS  Google Scholar 

  192. Lopez, J. S., de Smet, M. D., Masur, H., Mueller, B. U., Pizzo, P. A., and Nessenblatt, R. B. Orally administered 566C80 for treatment of ocular toxoplasmosis in a patient with the acquired immunodeficiency syndrome. Am. J. Ophthalmol., 113, 331, 1992.

    PubMed  CAS  Google Scholar 

  193. Tassignon, M. J., Brihaye, M., De Meuter, F., Vercruysse, A., Van Hoof, F., and De Wilde, F. Efficacy of treatments in experimental toxoplasmosis. Bull. Soc. Beige Ophthalmol., 230, 59, 1989.

    CAS  Google Scholar 

  194. Fish, R. H., Hoskins, J. C., and Kline, L. B. Toxoplasmosis neuroretinitis. Ophthalmology, 100, 1177, 1993.

    PubMed  CAS  Google Scholar 

  195. Falcone, P. M., Notis, C., and Merhige, K. Toxoplasmic papillitis as the initial manifestation of acquired immunodeficiency syndrome. Ann. Ophthalmol, 25, 56, 1993.

    CAS  Google Scholar 

  196. U.S. Public Health Service and Infectious Diseases Society of America. 1999 USPHS/IDSA guidelines for prevention of opportunistic infections in persons infected with human immunodeficiency virus. Infect. Dis. Obstet. Gynecol., 8, 574, 2000.

    Google Scholar 

  197. Antinori, A., Muni, R., Ammassari, A., et al. Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. AIDS, 9, 1343, 1995.

    Article  PubMed  CAS  Google Scholar 

  198. Nielsen, T. L., Jensen, B. N., Nelsing, S., Mathiesen, L. R., Skinhoj, P., and Nielsen, J. O. Randomized study of sulfamethoxazole-trimethoprim versus aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with AIDS. Scand. J. Infect. Dis., 27, 217, 1995.

    Article  PubMed  CAS  Google Scholar 

  199. Klinker, H., Langmann, P., and Richter, E. Pyrimethamine alone as prophylaxis for cerebral toxoplasmosis in patients with advanced HIV infection. Infection, 24, 324, 1996.

    Article  PubMed  CAS  Google Scholar 

  200. Jacobson, M. A., Besch, C. L., Child, C., et al. Primary prophylaxis with pyrimethamine for toxoplasmic encephalitis in patients with advanced human immunodeficiency virus disease: results of a randomized trial. J. Infect. Dis., 169, 384, 1994.

    Article  PubMed  CAS  Google Scholar 

  201. Van Delden, C., Gabriel, V., Sudre, P., Flepp, M., von Overbeck, J., Hirschel, B., and the Swiss HIV Cohort Study. Reasons for failure of prevention of Toxoplasma encephalitis. AIDS, 10, 509, 1996.

    Article  PubMed  Google Scholar 

  202. Ribera, E., Fernandez-Sola, A., Juste, C., et al. Comparison of high and low doses of trimethoprim-sulfamethoxazole for primary prevention of toxoplasmic encephalitis in human immunodeficiency virus-infected patients. Clin. Infect. Dis., 29, 1461–1466, 1999.

    Article  PubMed  CAS  Google Scholar 

  203. Saillourglenisson, F., Chene, G., Salmi, L. R., Hafner, R., and Salamon, R. Effet de la dapsone sur la survie des patients infectes par le VIH: une metanalyse des essais termines. Rev. Epidemiol. Sante Publique, 48, 17–30, 2000.

    PubMed  CAS  Google Scholar 

  204. Antinori, A., Muni, R., Ammassari, A., et al. Risk of bacterial infections in a cohort of HIV-positive patients receiving anti P. carinii/T. gondii prophylaxis. 38th Intersci. Conf. Antimicrob. Agents Chemother., American Society of Microbiology, Washington DC, 549, abstract L-9, 1998.

    Google Scholar 

  205. Gourdon, F., Laurichesse, H., Dalens, H., et al. Ocular toxoplasmosis: clinical experience using pyrimethamine as secondary prophylaxis. 38th Intersci. Conf. Antimicrob. Agents Chemother., American Society of Microbiology, Washington DC, 566, abstract L-66, 1998.

    Google Scholar 

  206. Jubault, V., Pacanowski, J., Rabian, C., and Viard, J. P. Interruption of prophylaxis for major opportunistic infections in HIV-infected patients receiving triple combination antiretroviral therapy. Ann. Med. Interne (Paris), 151, 163–168, 2000.

    CAS  Google Scholar 

  207. Maenza, J. Discontinuation of prophylaxis in HAART-responders. Hopkins HIV Rep, 11, 2–3, 1999.

    CAS  Google Scholar 

  208. Furrer, H., Opravil, M., Bernasconi, E., Telenti, A., and Egger, M. Stopping primary prophylaxis in HIV-1-infected patients at high risk of Toxoplasma encephalitis. Swiss HIV Cohort Study. Lancet, 355(9222), 2217–2218, 2000.

    Google Scholar 

  209. Mussini, C., Pezotti, P., Govoni, A., et al. Discontinuation of primary prophylaxis for Pneumocistis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus type I-infected patients: the changes in opportunistic prophylaxis study. J. Infect. Dis., 181, 1635–1642, 2000.

    Article  PubMed  CAS  Google Scholar 

  210. Guex, A. C., Radziwill, A. J., and Bucher, H. C. Discontinuation of secondary prophylaxis for toxoplasmic encephalitis in human immunodeficiency virus infection after immune restoration with highly active antiretroviral therapy. Clin. Infect. Dis., 30, 602–603, 2000.

    Article  PubMed  CAS  Google Scholar 

  211. Antinori, A., Cingolani, A., Ammassari, A., Pezzotti, P., Muni, R., de Luca, A., Larocca, L. M., and Ortona, L. AIDS-related focal brain lesions in the era of HAART. 6th Conf. Retroviral Opportunistic Infect., Jan. 31—Feb. 4, 145, abstract 413, 1999.

    Google Scholar 

  212. Ravaux, I., Quinson, A. M., Chadapaud, S., and Gallais, H. Discontinue primary and secondary prophylaxis regimens in selected HIV-infected patients treated with HAART. 38th Intersci. Conf. Antimicrob. Agents Chemother., American Society of Microbiology, Washington DC, 429, abstract I - 203, 1998.

    Google Scholar 

  213. Moore, R. D., Keruly, J. C., and Chaisson, R. E. Decline in CMV and other opportunistic diseases with combination antiretroviral therapy. 5th Conf. Retroviral Opportunistic Infect., Feb. 1–5, 113, abstract 184, 1998.

    Google Scholar 

  214. Soriano, V., Dona, C., Rodriguez-Rosado, R., Barreiro, P., and Gonzalez-Lahoz, J. Discontinuation of secondary prophylaxis for opportunistic infections in HIV-infected patients receiving highly active retroviral therapy. AIDS, 14, 383386, 2000.

    Google Scholar 

  215. Michaels, S., Clark, R., and Kissinger, P. Differences in the incidence rates of opportunistic processes before and after the availability of protease inhibitors. 5th Conf. Retroviral Opportunistic Infect., Feb. 1–5, 112, abstract 180, 1998.

    Google Scholar 

  216. Rodriguez-Rosado, R., Soriano, V., Dona, C., and Gonzalez-Lahoz, J. Opportunistic infections shortly after beginning highly active retroactive antiretroviral therapy. Antiviral Ther, 3, 229–231, 1998.

    CAS  Google Scholar 

  217. Krahenbuhl, J. L. and Remington, J. S. The immunology of toxoplasma and toxoplasmosis, in Immunology of Parasitic Infections, Cohen, S. and Warren, K. S., Eds. Blackwell, Oxford, 356, 1982.

    Google Scholar 

  218. Gallin, J. I., Farber, J. M., Holland, S. M., and Nitman, T. B. Interferon-gamma in the management of infectious diseases [clinical conference]. Ann. Intern. Med., 123, 216, 1995 [see comments in Ann. Intern. Med., 124, 1095, 1996 ].

    Google Scholar 

  219. Yap, G., Pesin, M., and Sher, A. Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen. Toxoplasma gondii. J. Immunol., 165, 628–631, 2000.

    CAS  Google Scholar 

  220. Suzuki, Y. Genes, cells and cytokines in resistance against development of toxoplasmic encephalitis. Immunobiology, 201, 255–271, 1999.

    Article  PubMed  CAS  Google Scholar 

  221. McCabe, R. E., Luft, B. J., and Remington, J. S. Effect of murine interferon gamma on murine toxoplasmosis. J. Infect. Dis., 150, 961, 1984.

    Article  PubMed  CAS  Google Scholar 

  222. Fegies, M. and Guerrero, J. Treatment of toxoplasmosis with levamisole. Trans. R. Soc. Trop. Med. Hyg., 71, 178, 1977.

    Article  PubMed  CAS  Google Scholar 

  223. Zastera, M., Fruehbauer, Z., and Pokorny, J. Levamisole therapy of experimental toxoplasmosis in white mice. Cesk. Epidemiol. Mikrobiol. Immunol., 31, 94, 1982.

    CAS  Google Scholar 

  224. Youssef, M. Y., el-Ridi, A. M., Arafa, M. S., el-Sawy, M. T., and el-Sayed, W. M. Effect of levamisole on toxoplasmosis during pregnancy in guinea pigs. J. Egypt. Soc. Parasitol., 15, 41, 1985.

    PubMed  CAS  Google Scholar 

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Georgiev, V.S. (2003). Toxoplasma gondii. In: Opportunistic Infections. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-296-8_15

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