Abstract
Ultrasound was used to evaluate the acoustic properties of bone as early as the 1950s (1–3). However, enthusiasm for the application of ultrasound measurements as a clinical tool to assess skeletal status developed only after the pioneering work of Langton and colleagues in 1984 (4), who reported that broadband ultrasound attenuation (BUA) measurements in the calcaneus discriminated between elderly women who had sustained a hip fracture and those with no history of fracture. In the nearly two decades since this initial report, there have been major advances in the use of ultrasound for determining skeletal status. Quantitative ultrasound (QUS) devices are now approved by the FDA and equivalent regulatory agencies throughout the world for clinical use in the evaluation of osteoporosis and prediction of fracture risk. As a result of data from large, prospective trials (5–8), there is now widespread consensus that QUS measurements are useful for assessing fracture risk in both elderly and peri-menopausal women (see Chapter 7).
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Bouxsein, M.L. (2003). Technical Aspects of Skeletal Assessment Using Quantitative Ultrasound. In: Orwoll, E.S., Bliziotes, M. (eds) Osteoporosis. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-278-4_6
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