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Vaccines Against Streptococcus pneumoniae

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Abstract

Streptococcus pneumoniae is an important bacterial pathogen, especially for the very young and the very old (1). S. pneumoniae, also referred to as the pneumococcus, was formerly known as Diplococcus pneumoniae.

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References

  1. Musher, D. M. (1993) Streptococcus pneumoniae, in Principles and Practice of Infectious Diseases, 4th ed. (Mandell, G. L., Douglas, R. G., and Bennett, J. E., eds.), Churchill Livingstone, New York, pp. 1811–1826.

    Google Scholar 

  2. Centers for Disease Control (1997). Recommendations of the advisory committee on immunization practices (ACIP). Prevention of pneumococcal disease. MMWR 46 (No. RR-8), 1–24.

    Google Scholar 

  3. Leowski, J. (1986) Mortality from acute respiratory infection in children less than 5 years of age: global estimates. World Health Stat. Q. 39, 138–144.

    PubMed  CAS  Google Scholar 

  4. Austrian, R. (1989) Pneumococcal polysaccharide vaccines. Rev. Infect. Dis. 11 (Suppl. 3), S598 — S602.

    Article  PubMed  Google Scholar 

  5. Henrichsen, J. (1995) Six newly recognized types of Streptococcus pneumoniae. J. Clin. Microbiol. 33 (10), 2759–2762.

    CAS  Google Scholar 

  6. Breiman, R. F., Butler, J. C., Tenover, F. C., Elliott, J. A., and Facklam, R. R. (1994) Emergence of drug-resistant pneumococcal infections in the United States. DAMA 271 (23), 1831–1835.

    Article  CAS  Google Scholar 

  7. Sniadack, D. H., Schwartz, B., Lipman, H., Bogaerts, J., Butler, J. C., Dagan, R., EchanizAviles, G., Lloyd-Evans, N., Fenoll, A., Girgis, N. I., Henrichsen, J., Klugman, K., Lehmann, D., Takala, A. K., Vandepitte, J., Gove, S., and Breiman, R. F. (1995) Potential interventions for the prevention of childhood pneumonia: geographic and temporal differences in serotype and serogroup distribution of sterile site pneumococcal isolates from children-implications for vaccine strategies. Pediatr. Infect. Dis. J. 14, 503–510.

    Article  PubMed  CAS  Google Scholar 

  8. Robbins, J. B., Schneerson, R., Anderson, P., and Smith, D. H. (1996) Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. DAMA 276 (14), 1181–1185.

    Article  CAS  Google Scholar 

  9. Townsend, G. C. and Scheid, W. M. (1995) Clinically important trends in bacterial meningitis. Infect. Dis. Clin. Pract. 4 (6), 423–430.

    Article  Google Scholar 

  10. Watson, D. A., Musher, D. M., and Verhoef, J. (1995) Pneumococcal virulence factors and host immune responses to them. Eur. J. Clin. Microbiol. Infect. Dis. 14 (6), 479–490.

    Article  PubMed  CAS  Google Scholar 

  11. Virolainen, A., Jero, J. Kayhty, H., Karma, P., Leinonen, M., and Eskola, J. (1995) Nasopharyngeal antibodies to pneumococcal capsular polysaccharides in children with acute otitis media. J. Inf. Dis. 172, 1115–1118.

    CAS  Google Scholar 

  12. Klein, D. L. (1995) Pneumococcal conjugate vaccines: review and update. Microb. Drug Resist. 1 (1), 49–58.

    Article  PubMed  CAS  Google Scholar 

  13. McDaniel, L. S., Sheffield, J. S., Delucchi, P., and Briles, D. (1991) PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type. Infect. Immun. 59, 222–228.

    PubMed  CAS  Google Scholar 

  14. Paton, J. C., Lock, R. A., and Hansman, D. J. (1983) Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae. Infect. Immun. 40, 548–552.

    CAS  Google Scholar 

  15. Finland, M. (1939) The use of serum, sulfanilamide and sulfapyridine in the treatment of pneumococci infections. Med. Clin. North Am. 23, 1205–1209.

    Google Scholar 

  16. Casadevall, A. and Scharff, M. D. (1995) Return to the past: the case for antibody-based therapies in infectious diseases. Clin. Infect. Dis. 21, 150–161.

    Article  PubMed  CAS  Google Scholar 

  17. Watson, D. A., Musher, D. M., Jacobson, J. W., and Verhoef, J. (1993) A brief history of the pneumococcus in biomedical research: a panoply of scientific discovery. Clin. Infect. Dis. 17 (5), 913–924.

    Article  PubMed  CAS  Google Scholar 

  18. MacLeod, C. M., Hodges, R. G., Heidelberger, M., et al. (1945) Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides. J. Exp. Med. 82, 445–465.

    Article  Google Scholar 

  19. Austrian, R. and Gold, J. (1964) Pneumococcal bacteremia, with special reference to bacteremic pneomococcal pneumonia. Ann. Int. Med. 60, 759–776.

    PubMed  CAS  Google Scholar 

  20. Smit, P., Oberholtzer, D., Hayden-Smith, S., Koornhof, H. J., and Hilleman, M. R. (1977) Protective efficacy of pneumococcal polysaccharide vaccines. JAMA 238, 2613–2616.

    Article  PubMed  CAS  Google Scholar 

  21. Shapiro, E. D., Berg, A. T., Austrian, R., Schroeder, D., Parcells, V., Margolis, A., Adair, R. K., and Clemens, J. D. (1991) The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N. Engl. J. Med. 325 (21), 1453–1460.

    Article  PubMed  CAS  Google Scholar 

  22. Koskela, M., Leinonen, M., Haiva, V., et al. (1986) First and second dose antibody responses to pneumococcal polysaccharide vaccine in infants. Pediatr. Infect. Dis. 5, 45–50.

    Article  PubMed  CAS  Google Scholar 

  23. Roghmann, K. J., Tabloski, P. A., Bentley, D. W., et al. (1987) Immune response of elderly adults to pneumococcus: variation by age, sex, and functional impairment. J. Gerontol. 42, 265–270.

    Article  PubMed  CAS  Google Scholar 

  24. Musher, D. M., Groover, J. E., Graviss, E. A., and Baughn, R. E. (1996) The lack of association between aging and postvaccination levels of IgG antibody to capsular polysaccharides of Streptococcus pneumoniae. Clin. Infect. Dis. 22, 165–167.

    Article  CAS  Google Scholar 

  25. Obaro, S. K., Monteil, M. A., and Henderson, D. C. (1996) The pneumococcal problem. Br. Med. J. 312 (7045), 1521–1525.

    Article  CAS  Google Scholar 

  26. Peter, G. and Klein, J. (1997) Streptococcus pneumoniae, in Principles and Practice of Pediatric Infectious Diseases (Long, S., Pichering, L., and Prober, C., eds. ), Churchill Livingstone, NY, pp. 828–835.

    Google Scholar 

  27. Hattotuwa, K. L. and Hind, C. R. K. (1997) Pneumococcal vaccine. Postgrad. Med. J. 73 (858), 222–224.

    Article  PubMed  CAS  Google Scholar 

  28. Stein, K. R. (1992) Thymus-independent and thymus-dependent responses to polysaccharide antigens. J. Inf. Dis. (Suppl 1), S49 - S52.

    Google Scholar 

  29. Robbins, J. B. and Schneerson, R. (1990) Evaluating the Haemophilus influenzae type b conjugate vaccine PRP-D. N. Engl. J. Med. 323, 1415, 1416.

    Google Scholar 

  30. Eby, R. (1995) Pneumococcal conjugate vaccines. Pharm. Biotechnol. 6, 695–718.

    Article  PubMed  CAS  Google Scholar 

  31. King, J. C. Jr., Vink, P. E., Farley, J. J., Parks, M., Smilie, M., Madore, D., Lichenstein, R., and Malinoski, F. (1996) Comparison of the safety and immunogenicity of a pneumococcal conjugate with a licensed polysaccharide vaccine in human immunodeficiency virus and non-human immunodeficiency virus-infected children. Pediatr. Infect. Dis. J. 15 (3), 192–196.

    Article  PubMed  Google Scholar 

  32. Rodriquez-Barradas, M., Musher, D., Lohart, C., Lacke, C., Groover, J., Watson, D., Baughn, R., Cate, T., and Crofoot, G. (1992) Antibody to capsular polysaccharides of Streptococcus pneumonia after vaccination of human immunodeficiency virus-infected subjects with 23-valent pneumococcal vaccine. J. Inf. Dis. 165, 553–556.

    Article  Google Scholar 

  33. Anderson, P. and Betts, R. (1989) Human adult immunogenicity of protein-coupled pneumococcal capsular antigens of serotypes prevalent in otitis media. Pediatr. Infect. Dis. J. 8, S50 — S53.

    Article  PubMed  CAS  Google Scholar 

  34. Steinhoff, M. C., Edwards, K., Keyserling, H., Thorns, M. L., Johnson, C., Madore, D., and Hogerman, D. (1994) A randomized comparison of three bivalent streptococcus pneumoniae glycoprotein conjugate vaccines in young children: effect of polysaccharide size and linkage characteristics. Pediatr. Infect. Dis. J. 13 (5), 368–372.

    Article  PubMed  CAS  Google Scholar 

  35. Riley, I. A. and Douglas, R. M. (1981) An epidemiologic approach to pneumococcal disease. Rev. Infect. Dis. 3, 233–245.

    Article  PubMed  CAS  Google Scholar 

  36. Dagan, R., Zamir, O., Melamed, R., and Leroy, O. (1996) Immunogenicity of two tetravalent pneumococcal vaccines conjugated to either tetanus toxoid (Pnc-TT) or diphtheria toxoid (Pnc-D) in young infants and their boosterability by native polysaccharide (PS) antigens. Paper presented at the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Louisiana, Sept. 15–18, American Society for Microbiology, Washington, DC, p. 151.

    Google Scholar 

  37. Anderson, E. L., Kennedy, D. J., Geldmacher, K. M., Donnelly, J., and Mendelman, P. M. (1996) Immunogenicity of heptavalent pneumococcal conjugate vaccine in infants. J. Pediatr. 128 (5, Part 1), 649–653.

    PubMed  CAS  Google Scholar 

  38. Pichichero, M. E., Shelly, M. A., and Treanor, J. J. (1997) Evaluation of a pentavalent conjugated pneumococcal vaccine in toddlers. Pediatr. Infect. Dis. J. 16 (1), 72–74.

    Article  PubMed  CAS  Google Scholar 

  39. Javier, F. C., Leiva, L., Moore, C., Bradford, N., and Sorensen, R. U. (1997) Conjugate vaccine in children who failed to respond to the 23-valent polysaccharide vaccine. J. Allergy Clin. Immunol. 99 (1, Part 2), S426.

    Google Scholar 

  40. Powers, D. C., Anderson, E. L., Lottenbach, K., and Mink, C. M. (1996) Reactogenicity and immunogenicity of a protein-conjugated pneumococcal oligosaccharide vaccine in older adults. J. Infect. Dis. 173 (4), 1014–1018.

    Article  PubMed  CAS  Google Scholar 

  41. Shelly, M. A., Graves, B., Riley, G. J., and Treanor, J. J. (1995) Comparison of pneumococcal polysaccharide (PS) and CRM-197-conjugated pneumococcal polysaccharide (CRM-PS) vaccines in young and older adults. Clin. Infect. Dis. 21 (3), 789.

    Google Scholar 

  42. Dagan, R., Melamed, R., Muallem, M., Piglansky, L., Greenberg, D., Abramson, O., Mendelman, P. M., Bohidar, N., and Yagupsky, P. (1996) Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine. J. Infect. Dis. 174 (6), 1271–1278.

    Article  PubMed  CAS  Google Scholar 

  43. Obaro, S. K., Adegbola, R. A., Banya, W. A. S., and Greenwood, B. M. (1996) Carriage of pneomococci after pneumococcal vaccination. Lancet 348(9022), 271, 272.

    Google Scholar 

  44. Ulmer, J. B. (1997) Elegantly presented DNA vaccines. Nat. Biotechnol. 15, 842, 843.

    Google Scholar 

  45. Klein, J. (1994) Otitis Media. Clin. Infect. Dis. 19, 823–833.

    Article  PubMed  CAS  Google Scholar 

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Brown, K.R., Ricci, F.M. (1999). Vaccines Against Streptococcus pneumoniae . In: Ellis, R.W. (eds) Combination Vaccines. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-265-4_7

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  • DOI: https://doi.org/10.1007/978-1-59259-265-4_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4802-4

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