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Molecular and Cellular Basis of Inflammation pp 141–163Cite as

Isoprostanes as Markers of Lipid Peroxidation in Atherosclerosis

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Part of the book series: Current Inflammation Research ((CIRES))

Abstract

Cardiovascular disease is one of the leading causes of morbidity and mortality in the United States. Central to the process of atherogenesis is the uptake of LDL by macrophages resulting in formation of foam cells in the vascular wall. Thus, insights into the mechanism that leads to the uptake of LDL by macrophages are key to understanding the pathogenesis of atherosclerosis. Native LDL is not internalized by macrophages. However, chemical modification of LDL apolipoprotein B-100 converts the LDL into a ligand for scavenger receptors on macrophages, which leads to rapid uptake of the modified LDL (1–3). Because the scavenger pathway of LDL uptake lacks feedback inhibition by intracellular cholesterol content, massive accumulation of modified LDL can occur, resulting in foam cell formation.

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Authors
  1. L. Jackson Roberts II
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  2. Jason D. Morrow
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Editors and Affiliations

  1. Department of Anesthesia, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Charles N. Serhan

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Peter A. Ward

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Roberts, L.J., Morrow, J.D. (1999). Isoprostanes as Markers of Lipid Peroxidation in Atherosclerosis. In: Serhan, C.N., Ward, P.A. (eds) Molecular and Cellular Basis of Inflammation. Current Inflammation Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-253-1_7

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  • DOI: https://doi.org/10.1007/978-1-59259-253-1_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-089-2

  • Online ISBN: 978-1-59259-253-1

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