Skip to main content
SpringerLink
Log in
Book cover

Molecular and Cellular Basis of Inflammation pp 309–324Cite as

Lupus Erythematosus

The Role of Adhesion Molecules and Local Mediators

  • Chapter

Part of the book series: Current Inflammation Research ((CIRES))

Abstract

Inflammation in systemic lupus erythematosus (SLE) is mediated by a complex interaction of the cellular and humoral components of the immune system. Central to the development of tissue injury is an interaction between inflammatory cells and vascular endothelium, which requires the recruitment, activation, and ligation of surface adhesion molecules. These events, induced by immune complexes, cytokines, and complement components are prerequisite for leukocyte egress and local mediator production. This chapter will review mediators that act on inflammatory and endothelial cells to promote vascular injury in SLE.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Takabayashi, T., Vannier, E., Clark, B. D., Margolis, N. H., Dinarello, C. A., Burke, F., and Gelfand, J. A. (1996) A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis. J. Immunol 156, 3455–3460.

    PubMed  CAS  Google Scholar 

  2. Stein, J. M. and Luzio, J. P. (1989) Membrane sorting during vesicle shedding from neutrophils during sublytic complement attack. Biochem. Soc. Trans. 16, 1082,1083.

    Google Scholar 

  3. Morgan, B. P., Dankert, J. R., and Esser, A. R (1987) Recovery of human neutrophils from complement attack: Removal of the membrane attack complex by endocytosis and exocytosis. J. Immunol 138, 246–253.

    PubMed  CAS  Google Scholar 

  4. Morgan, B. P. (1989) Complement membrane attack on nucleated cells: resistance, recovery and nonlethal effects. Biochem. J. 264, 1–14.

    PubMed  CAS  Google Scholar 

  5. Hattori, R., Hamilton, K. K., McEver, R. P., and Sims, P. J. (1989) Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane. J. Biol. Chem. 264, 9053–9060.

    PubMed  CAS  Google Scholar 

  6. Biesecker, G., Katz, S., and Koffler, D. (1981) Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis. J. Exp. Med. 154, 1779–1794.

    Article  PubMed  CAS  Google Scholar 

  7. Biesecker, G., Lavin, L., Zisking, M., and Koffler, D. (1982) Cutaneous localization of the membrane attack complex in discoid and systemic lupus erythematosus. N. Engl. J. Med. 306, 264–270.

    Article  PubMed  CAS  Google Scholar 

  8. Kissel, J. T., Mendell, J. R., and Rammohan, K. W. (1986) Microvascular deposition of complement membrane attack complex in dermatomyositis. N. Engl. J. Med. 314, 329–334.

    Article  PubMed  CAS  Google Scholar 

  9. Schäfer, H., Mathey, D., Hugo, R., and Bhakdi, S. (1986) Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium. J. Immunol., 137, 1945–1949.

    PubMed  Google Scholar 

  10. Ruddy, S., Carpenter, C. B., Chin, K. W., Knostman, J. N., Soter, N. A., Gotze, O., Muller-Eberhard, H. J., and Austen, K. F. (1975) Human complement metabolism: an analysis of 144 studies. Medicine (Baltimore) 54, 165–178.

    Google Scholar 

  11. Charlesworth, J. A., Williams, D. G., Sherington, E., Lachmann, P. J., and Peters, D. K. (1974) Metabolic studies of the third component of complement and the glycine rich glycoprotein in patients with hypocomplementemia. J. Clin. Invest. 53, 1578–1587.

    Article  PubMed  CAS  Google Scholar 

  12. Sliwinski, A. J. and Zvaifler, N. J. (1972) Decreased synthesis of the third component (C3) in hypocomplementemic systemic lupus erythematosus. Clin. Exp. Immunol. 11, 21–29.

    PubMed  CAS  Google Scholar 

  13. Kerr, L., Adelsberg, B. R., Schulman, P., and Spiera, H. (1989) Factor B activation products in patients with systemic lupus erythematosus: a marker of severe disease activity. Arthritis Rheum. 32, 1406–1413.

    Article  PubMed  CAS  Google Scholar 

  14. Falk, R. J., Dalmasso, A. P., Kim, Y., Lam, S., and Michael, A. (1985) Radioimmunoassay of the attack complex of complement in serum from patients with systemic lupus erythematosus. N. Engl. J. Med. 312, 1594–1599.

    Article  PubMed  CAS  Google Scholar 

  15. Belmont, H. M., Hopkins, P., Edelson, H. S., Kaplan, H. B., Ludewig, R., Weissmann, G., and Abramson, S. (1986) Complement activation during systemic lupus erythematosus: C3a and C5a anaphylatoxins circulate during exacerbations of disease. Arthritis Rheum. 29, 1085–1089.

    Article  PubMed  CAS  Google Scholar 

  16. Buyon, J., Tamerius, J., Belmont, H. M., and Abramson, S. (1992) Assessment of disease activity and impending flare in patients with systemic lupus erythematosus: comparison of the use of complement split products and conventional measurements of complement. Arthritis Rheum. 35, 1028–1037.

    Article  PubMed  CAS  Google Scholar 

  17. Buyon, J., Tamerius, J., Ordica, S., Young, B., and Abramson, S. (1992) Activation of the alternative complement pathway accompanies disease flares in systemic lupus erythematosus during pregnancy. Arthritis Rheum. 35, 55–61.

    Article  PubMed  CAS  Google Scholar 

  18. Hopkins, P. T., Belmont, H. M., Buyon, J., Philips, M. R., Weissmann, G., and Abramson, S. B. (1988) Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis. Arthritis Rheum. 31, 632–641.

    Article  PubMed  CAS  Google Scholar 

  19. Ross, G. D. and Medof, M. E. (1985) Membrane complement receptors specific for bound fragments of C3. Adv. Immunol. 37, 217–267.

    Article  PubMed  CAS  Google Scholar 

  20. Schifferli, J. A., Ng, Y. C., and Peters, D. K. (1986) The role of complement and its receptor in the elimination of immune complexes. N. Engl. J. Med. 315, 488–495.

    Article  PubMed  CAS  Google Scholar 

  21. Philips, M. R., Abramson, S. B., and Weissmann, G. (1989) Neutrophil adhesion and autoimmune vascular injury. Clin. Aspects Autoimmunity 3, 6–15.

    Google Scholar 

  22. Yong, K. and Khwaja, A. (1990) Leukocyte cellular adhesion molecules. Blood Rev. 4, 211–225.

    Article  PubMed  CAS  Google Scholar 

  23. McEver, R. P. (1991) Selectins: novel receptors that mediate leukocyte adhesion during inflammation. Thromb. Haemostasis 65, 223–228.

    CAS  Google Scholar 

  24. Lawrence, M. B. and Springer, T. A. (1991) Leukocytes role on a selection of physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65, 859–873.

    Article  PubMed  CAS  Google Scholar 

  25. Nikolic-Paterson, D. J., Lan, H. Y., Hill, P. A., and Atkins, R. C. (1994) Macrophages in renal injury. Kidney Int. 45, S79–S82.

    CAS  Google Scholar 

  26. Pytela, R., Pierschbacher, M., Ginsberg, M., Plow, E., and Rouslahti, E. (1986) Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp-specific adhesion receptors. Science 231, 1559–1562.

    Article  PubMed  CAS  Google Scholar 

  27. Johnson, R. J. (1991) Platelets in inflammatory glomerular injury. Semin. Nephrol. 11, 276–284.

    PubMed  CAS  Google Scholar 

  28. Pierucci, A., Simonetti, B. M., and Pecci, G. (1989) Improvement in renal function with selective thromboxane antagonism in lupus nephritis. N. Engl. J. Med. 320, 421–425.

    Article  PubMed  CAS  Google Scholar 

  29. Johnson, R. J., Lovett, D., Lehrer, R. I., Couser, W. G., and Klebanoff, S. J. (1994) Role of oxidants and proteases in glomerular injury. Kidney Int. 45, 352–359.

    Article  PubMed  CAS  Google Scholar 

  30. Koefiler, P., Schur, P., and Kunkel, H. (1967) Immunological studies concerning the nephritis of systemic lupus erythematosus. J. Exp. Med. 126, 607–624.

    Article  Google Scholar 

  31. Fauci, T. Y., Haynes, B. F., and Katz, P. (1978) The spectrum of vasculitis. Ann. Int. Med. 89, 660–676.

    Article  PubMed  CAS  Google Scholar 

  32. Arthus, M. (1903) Injections répétées de serum de cheval chez la lapin. Soc. Biol. 847–850.

    Google Scholar 

  33. Ishizaka, K. (1963) Gamma globulin and molecular mechanisms in hypersensitivity reations, in Progress in Allergy, vol. 7 (Kallos, P. and Waksman, B. H., eds.), Karger, New York, pp. 32–106.

    Google Scholar 

  34. Frank, M. M., Ellman, L., Green, I., and Cochrane, C. (1973) Site of deposition of C3 in arthus reactions of C4 déficient guinea pigs. J. Immunol. 110, 11,447–11,451.

    Google Scholar 

  35. Lawley, T. J. and Frank, M. M. (1980) Immune complexes and immune complex diseases, in Clinical Immunology (Parker, C. W., ed.) Saunders, Philadelphia, pp. 143.

    Google Scholar 

  36. Cochrane, C. G. (1965) The Arthus reaction, in The Inflammatory Process (Zweifach, B. W., Grant, L., and McCluskey, R. T., eds.), Academic, New York, pp. 613–648.

    Google Scholar 

  37. Sylvestre, D. L. and Ravetch, J. V. (1994) Fc receptors initiate the Arthus reaction: Redefining the inflammatory cascade. Science 265, 1095–1098.

    Article  PubMed  CAS  Google Scholar 

  38. Hopkins, P., Belmont, M., Buyon, J., Philips, M. R., Weissmann, G., and Abramson, S. B. (1988) Increased plasma anaphylotoxins in systemic lupus erythematosus predict flares of the disease and may elicit the adult cerebral distress syndrome. Arthritis Rheum. 31, 632–641.

    Article  PubMed  CAS  Google Scholar 

  39. Belmont, H. M., Buyon, J., Giorno, R., and Abramson, S. B. (1994) Upregulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus: the Shwartzman Phenomenon revisited. Arthritis Rheum. 37, 376–383.

    Article  PubMed  CAS  Google Scholar 

  40. Jacob, H. S., Craddock, P. R., Hammerschmidt, D. E., and Moldow, C. F. (1980) Complement-induced granulocyte aggregation: an unsuspected mechanism of disease. N. Engl. J. Med. 302, 789–794.

    Article  PubMed  CAS  Google Scholar 

  41. Hammerschmidt, D. E., Weaver, L. J., Hudson, L. D., Craddock, P. R., and Jacob, H. S. (1980) Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Lancet 1, 947–949.

    Article  PubMed  CAS  Google Scholar 

  42. Hakim, R., Breillatt, J., Lazarus, M., and Prt, K. (1984) Complement activation and hypersensitivity reactions to hemodialysis membranes. N. Engl. J. Med. 311, 878–882.

    Article  PubMed  CAS  Google Scholar 

  43. Craddock, P., Fehr, J., Dalmasso, A., Brigham, K., and Jacob, H. (1977) Hemodialysis leukopenia. J. Clin. Invest. 59, 879–888.

    Article  PubMed  CAS  Google Scholar 

  44. Chenoweth, D. E., Cooper, S. W., Hugli, T. E., Stewart, R. W., Balckstone, E. H., and Kirklin, S. W. (1981) Complement activation during cardiopulmonary bypass. N. Engl. J. Med. 304, 497–505.

    Article  PubMed  CAS  Google Scholar 

  45. Perez, H. D., Horn, J. K., Ong, R., and Goldstein, I. (1983) Complement (C5)-derived chemotactic activity in serum from patients with pancreatitis. J. Lab. Clin. Med. 101, 123–129.

    PubMed  CAS  Google Scholar 

  46. Shwartzman, G. (1937) Phenomenon of Local Tissue Reactivity. Paul Hoeber, New York.

    Google Scholar 

  47. Argenbright, L. and Barton, R. (1992) Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo: the Shwartzman Phenomenon revisited. J. Clin. Invest. 89, 259–273.

    Article  PubMed  CAS  Google Scholar 

  48. Abramson, S. B. and Weissmann, G. (1988) Complement split products and the pathogenesis of SLE. Hosp. Pract 23(12), 45–55.

    CAS  Google Scholar 

  49. Pohlman, T. M., Stanness, K. A., Beatty, P. G., Ochs, H. D., and and Harlan, J. M. (1986) J. Immunol. 136, 4548–4553.

    PubMed  CAS  Google Scholar 

  50. Pober, J. S., Gimbrone, M., Lapierre, D., Mendrick, L., Fiers, W., Rothlein, R., and Springer, T. (1986) Overlapping patterns of activation of human endothelial cells by interleukin-1, tumor necrosis factor and immune Interferon. J. Immunol 137, 1893–1896.

    PubMed  CAS  Google Scholar 

  51. Fletcher, M. P., Seligmann, B. E., and Gallin, J. I. (1982) Correlation of human neutrophil secretion, chemoattractant receptor mobilization and enhanced functional capacity. J. Immunol. 128, 941.

    PubMed  CAS  Google Scholar 

  52. Schur, P. H. and Sandson, J. (1968) Immunologic factors and clinical activity in systemic lupus erythematosus. N. Engl. J. Med. 278, 533–538.

    Article  PubMed  CAS  Google Scholar 

  53. Buyon, J. P., Shadick, N., Berkman, R., Hopkins, P., Dalton, J., Weissmann, G., Winchester, R., and Abramson, S. B. (1988) Surface expression of gp165/95, the complement receptor CR3, as a marker of disease activity in systemic lupus erythematosus. Clin. Immunol. Immunopathol 46, 141–149.

    Article  PubMed  CAS  Google Scholar 

  54. Johnson, R. T. and Richardson, E. P. (1968) The neurological manifestations of systemic lupus erythematosus: a clinical pathological study of 24 cases and a review of the literature. Medicine (Baltimore) 47, 337–369.

    Article  CAS  Google Scholar 

  55. Ellis, S. G. and Verity, M. A. (1979) Central nervous system involvement in systemic lupus erythematosus: a review of the neuropathologic findings in 57 cases, 1955-1977. Semin. Arthritis Rheum. 8, 212–233.

    Article  PubMed  CAS  Google Scholar 

  56. Hammad, A., Tsukada, Y., and Torre, N. (1992) Cerebral occlusive vasculopathy in systemic lupus erythematosus and speculation on the part played by complement. Ann. Rheum. Dis. 51, 550–552.

    Article  PubMed  CAS  Google Scholar 

  57. Devinsky, O., Petito, C. K., and Alonso, D. R. (1988) Clinical and neuropathological findings in systemic lupus erythematosus: the role of vasculitis heart emboli and thrombotic thrombocytopenic purpura. Ann. Neurol. 23, 380.

    Article  PubMed  CAS  Google Scholar 

  58. Abramson, S. B., Dobro, J., Eberle, M. A., Benton, M., Reibman, J., Epstein, H., Belmont, H. M., Rapoport, D. M., and Goldring, R. M. (1991) The syndrome of acute reversible hypoxemia of systemic lupus erythematosus. Ann. Int. Med. 114, 941–947.

    Article  PubMed  CAS  Google Scholar 

  59. Hughes, G. R. and Khamashta, M. A. (1994) The antiphospholipid syndrome. J. Royal Coll. Phys. London 28, 301–304.

    CAS  Google Scholar 

  60. Ordi-Ros, J., Perez-Peman, P., and Monasterio, J. (1994) Clinical and therapeutic aspects associated to phospholipid binding antibodies (lupus anticoagulant and anticardiolipin antibodies). Haemostasis 24, 165–174.

    PubMed  CAS  Google Scholar 

  61. Bevers, E. M. and Galli, M. (1992) Cofactors involved in the antiphospholipid syndrome. Lupus 1, 51–53.

    Article  PubMed  CAS  Google Scholar 

  62. Ozawa, N., Makino, T., Matsubayashi, H., Hosokawa, T., Someya, K., Nozawa, S., and Matsuura, E. (1994) Beta 2-GPI-dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions. J. Clin. Lab. Analysis 8, 255–259.

    Article  CAS  Google Scholar 

  63. Aron, A. L., Gharavi, A. E., and Shoenfeld, Y. (1995) Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome. Int. Arch. Allergy Immunol 106, 8–12.

    Article  PubMed  CAS  Google Scholar 

  64. Pierangeli, S. S. and Harris, E. N. (1994) Antiphospholipid antibodies in an in vivo thrombosis model in mice. Lupus 3, 247–251.

    Article  PubMed  CAS  Google Scholar 

  65. Triplett, D. A. (1992) Antiphospholipid antibodies: proposed mechanisms of action. Am. J. Reprod. Immunol. 28, 211–215.

    Article  PubMed  CAS  Google Scholar 

  66. Wiener, H. M., Vardinon, N., and Yust, I. (1991) Platelet antibody binding and spontaneous aggregation in 21 lupus anticoagulant patients. Vox Sanguinis 61, 111–121.

    Article  PubMed  CAS  Google Scholar 

  67. Vazquez-Mellado, J., Llorente, L., Richaud-Patin, Y., and Alarcon-Segovia, D. (1994) Exposure of anionic phospholipids upon platelet activation permits binding of beta 2 glycoprotein I and through it that of IgG antiphospholipid antibodies: studies in platelets from patients with antiphospholipid syndrome and normal subjects. J. Autoimmunity 7, 335–348.

    Article  CAS  Google Scholar 

  68. Lindsey, N. J., Henderson, F. I., Malia, R., Milford-Ward, M. A., Greaves, M., and Hughes, P. (1994) Inhibition of prostacyclin release by endothelial binding anticardiolipin antibodies in thrombosis-prone patients with systemic lupus erythematosus and the antiphospholipid syndrome. Br. J. Rheumatol. 33, 20–26.

    Article  PubMed  CAS  Google Scholar 

  69. Westerman, E. M., Miles, J. M., Backonja, M., and Sundstrom, W R. (1992) Neuropathologic findings in multiinfarct dementia associated with anticardiolipin antibody: evidence for endothelial injury as the primary event. Arthritis Rheum. 35, 1038–1041.

    Article  PubMed  CAS  Google Scholar 

  70. McCraw, K. R., DeMichele, A., Samuels, P., Roth, D., Kuo, A., Meng, Q. H., Rauch, J., and Cines, D. B. (1991) Detection of endothelial cell-reactive immunoglobulin in patients with antiphospholipid antibodies. Br. J. Haematol. 79, 595–605.

    Article  Google Scholar 

  71. Silver, R. K., Adler, L., Hickman, A. R., and Hageman, J. R. (1991) Anticardiolipin antibody-positive serum enhances endothelial cell platelet-activating factor production. Am. J. Obst. Gyn. 165, 1748–1752.

    Article  CAS  Google Scholar 

  72. Freyssinet, J. M., Toti-Orfanoudakis, F., Ravanat, C., Grunebaum, L., Gauchy, J., Cazenave, J. P., and Wiesel, M. L. (1991) The catalytic role of anionic phospholipids in the activation of protein C by factor Xa and expression of its anticoagulant function in human plasma. Blood Coagul Fibrin 2, 691–698.

    Article  CAS  Google Scholar 

  73. Joseph, J. and Scopelitis, E. (1994) Seronegative antiphospholipid syndrome associated with plasminogen activator inhibitor. Lupus 3, 201–203.

    Article  PubMed  CAS  Google Scholar 

  74. Ahmed, K., Vianna, J., Khamashta, M., and Hughes, G. (1992) IL-2, IL-6, and TNF levels in primary antiphospholilip antibody syndrome. Clin. Exp. Rheumatol. 10, 503 (letter).

    PubMed  CAS  Google Scholar 

  75. Simantov, R., LaSala, J. M., Lo, S. K., Gharavi, E., Sammaritano, L. R., Salmon, J. E., and Silverstein, R. L. (1996) Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J. Clin. Invest. 96, 2211–2219.

    Article  Google Scholar 

  76. Strieker, R. B., Davis, J. A., Gershow, J., Yamamoto, K. S., and Kiprov, D. D. (1992) Thrombotic thrombocytopenic purpura complicating systemic lupus erythematosus: case report and literature review from the plasmapheresis era. J. Rheumatol. 19, 1469–1473.

    Google Scholar 

  77. Cockerell, C. J. and Lewis, J. E. (1993) Systemic lupus erythematosus-like illness associated with syndrome of abnormally large von Willebrand’s factor multimers. South. Med. J. 86, 951–953.

    Article  PubMed  CAS  Google Scholar 

  78. Moake, J. L., Rudy, C. K., Troll, J. H., Weinstein, M. J., Colannino, N. M., Azocar, J., Seder, R. H., Hong, S. L., and Deykin, D. (1982) Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N. Engi J. Med. 303, 1432–1435.

    Article  Google Scholar 

  79. Takahashi, H., Hanano, M., Wada, K., Tatewaki, W., Niwano, H., Tsubouchi, J., Nakano, M., Nakamura, T., and Shibata, A. (1991) Circulating thrombomodulin in thrombotic thrombocytopenic purpura. Am. J. Hematol. 38, 174–177.

    Article  PubMed  CAS  Google Scholar 

  80. Arnaout, M. A. and Colten, H. R. (1984) Complement C3 receptors: structure and function. Molec. Immun. 21, 1191–1199.

    Article  PubMed  CAS  Google Scholar 

  81. Bullard, D. C., King, P. D., Hicks, M. J., Dupont, B., Beaudet, A. L., and Eldon, K. B. (1997) Intercellular adnesion molecule-1 deficiency protects MRL/MpJ-Fas (lpr) mice from early lethality. J. Immunol. 159, 2057–2067.

    Google Scholar 

  82. Springer, T. Z., Teplow, D. B., and Dreyer, W. J. (1985) [Article title]. Nature 314, 540–542.

    Article  PubMed  CAS  Google Scholar 

  83. Belmont, H. M., Amin, A. R., Giorno, R., and Abramson, S. B. (1995) Inducible nitric oxide synthase expression by endothelial cells characterizes systemic lupus erythematosus disease exacerbation, submitted.

    Google Scholar 

  84. Nyberg, F., Acevedo, F., and Stephansson, E. (1997) Different patterns of soluble adhesion molecules in systemic and cutaneous lupus erythematosus. J. Immunol. 65, 230–235.

    Google Scholar 

  85. Berger, M. D., Birx, L., Wetzler, E. M., O’Shea, J. J., Brown, E. J., and Cross, A. S. (1985) Increased expression of C3b receptors or polymarphonuclear leukocytes induced by chemotac-tic factors and by purification procedures. J. Immunol. 135, 1342–1348.

    PubMed  CAS  Google Scholar 

  86. Kilgore, K. S., Shen, J. P., Miller, B. F., Ward, P. A., and Warren, J. S. (1995) Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha-induced endothelial cell expression of E-selectin abd ICAM-1. J. Immunol. 155, 1434–1441.

    PubMed  CAS  Google Scholar 

  87. Jones, S. M., Mathew, C. M., Dixey, J., Lovell, C. R., and McHugh, N. J. (1996) VCAM-1 expression on endothelium in lesions from cutaneous lupus erythematosus is increased compared with systemic and localized scleroderma. J. Exp. Med. 135, 678–686.

    CAS  Google Scholar 

  88. Lozada, C., Levin, R. I., Huie, M., Hirschhorn, R., Naime, D., Whitlow, M., Recht, P. A., Golden, B., and Cronstein, B. N. (1995) Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules. Proc. Natl. Acad. Sci. USA 92, 8378–8382.

    Article  PubMed  CAS  Google Scholar 

  89. Neng Lai, L. K., Leung, J. C., Bil Lai, K., Li, P. K., and Lai, C. K. (1996) Anti-DNA autoantibodies stimulate the release of interleukin—1 and interleukin-6 from human endothelial cells. J. Pathol. 178, 451–158.

    Article  PubMed  CAS  Google Scholar 

  90. Lai, K. N., Leung, J. C., Lai, K. B., Wong, K. C., and Lai, C. K. (1996) Upregulation of adhesion molecule expression on endothelial cells by anti-DNA autoantibodies in systemic lupus erythematosus. Clin. Immunol. Immunopathol. 81, 229–238.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. Michael Belmont
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Steven B. Abramson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anesthesia, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Charles N. Serhan

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Peter A. Ward

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Belmont, H.M., Abramson, S.B. (1999). Lupus Erythematosus. In: Serhan, C.N., Ward, P.A. (eds) Molecular and Cellular Basis of Inflammation. Current Inflammation Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-253-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-253-1_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-089-2

  • Online ISBN: 978-1-59259-253-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation