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Role of Complement in Endothelial Cell Activation

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Molecular and Cellular Basis of Inflammation

Part of the book series: Current Inflammation Research ((CIRES))

Abstract

Complement has long been known to play a key role in the inflammatory response, although the precise mechanisms of its influences are uncertain. Intravascular activation of the complement pathway occurs as a result of the sequential activation of a cascade of proteolytic enzymes. Generation of numerous bioactive complement-derived products in turn evoke a complex series of cardiovascular responses. In vivo and in vitro inflammatory models serve to demonstrate the mechanisms of inflammatory injury, specifically defining complement interaction with vascular endothelial cells, and may provide insights into the central role of complement in the inflammatory response. The contribution of complement activation through an interaction with and activation of vascular endothelial cells is the focus of this chapter.

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Authors
  1. Peter A. Ward
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  2. Hedwig S. Murphy
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Editors and Affiliations

  1. Department of Anesthesia, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Charles N. Serhan

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Peter A. Ward

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Ward, P.A., Murphy, H.S. (1999). Role of Complement in Endothelial Cell Activation. In: Serhan, C.N., Ward, P.A. (eds) Molecular and Cellular Basis of Inflammation. Current Inflammation Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-253-1_1

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  • DOI: https://doi.org/10.1007/978-1-59259-253-1_1

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