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Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs

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Modern Therapeutics in Rheumatic Diseases
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Abstract

Physicians have the capacity to attenuate most types of pain, but the effectiveness of the presently available medications is typically limited by their toxic effects. One such class of analgesic medications is the nonsteroidal anti-inflammatory drugs (NSAIDs), which have been shown to be anti-inflammatory, analgesic, and antipyretic. NSAIDs represent one of the most commonly used classes of drugs in the world, with more than 17,000,000 Americans using various NSAIDs on a daily basis.

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References

  1. Morbidity and Mortality Weekly Report, 1994.

    Google Scholar 

  2. Morbidity and Mortality Weekly Report, 1995.

    Google Scholar 

  3. Simon, L.S., F.L. Lanza, P.E. Lipsky, R.C. Hubbard, S. Talwalker, B.D. Schwartz, et al. 1998. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. Arthritis Rheum. 41:1591–1602.

    Article  PubMed  CAS  Google Scholar 

  4. Rehman, Q. and N.E. Lane. 1999. Getting control of osteoarthritis pain. An update on treatment options. Postgrad. Med. 106:127–134

    PubMed  CAS  Google Scholar 

  5. Brooks, P.M. and R.O. Day. 1991. Nonsteroidal antiinflammatory drugs: differences and similarities. N. Engl. J. Med. 324:1716–1725.

    Article  PubMed  CAS  Google Scholar 

  6. Simon, L.S. and V. Strand. 1997. Clinical response to nonsteroidal antiinflammatory drugs. Arthritis Rheum. 40:1940–1943

    Article  PubMed  CAS  Google Scholar 

  7. Fosslien, E. 1998. Adverse effects of nonsteroidal anti-inflammatory drugs on the gastrointestinal system. Ann. Clin. Lab. Sci. 28:67/81.

    Google Scholar 

  8. Silverstein, F.E., G. Faich, J.L. Goldstein, L.S. Simon, T. Pincus, A. Whelton, et al. 2000. The celecoxib long-term safety study (CLASS): a randomized double-blind controlled trial. JAMA 284: 1247–1255.

    Article  PubMed  CAS  Google Scholar 

  9. Laine, L., S. Harper, T. Simon, et al. 1999. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase-2 specific inhibitor, with that of ibuprofen on gastroduodenal mucosa of patients with osteoarthritis. Gastroenterology 117:776–783.

    Article  PubMed  CAS  Google Scholar 

  10. Leese, P., R. Hubbard, A. Karim, P. Isakson, S. Yu, and S. Geis. 2000. Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial. J. Clin. Pharmacol. 40:124–132.

    Article  PubMed  CAS  Google Scholar 

  11. Brater, C. 2000. Pharmacokinetics. In: Up to Date , Rose, B.D. (ed.), Up to Date, Wellesley, MA.

    Google Scholar 

  12. Schlondorff, D. 1993. Renal complications of nonsteroidal anti-inflammatory drugs. Kid. Int. 44:643–653.

    Article  CAS  Google Scholar 

  13. Brooks, P.M. and R.O. Day. 1991. Nonsteroidal antiinflammatory drugs: differences and similarities. N. Engl. J. Med. 324:1716–1725.

    Article  PubMed  CAS  Google Scholar 

  14. Mahmud, T., S.S. Rafi, D.L. Scott, J.M. Wrigglesworth, and I. Bjarnason. 1996. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum. 39:1998–2003.

    Article  PubMed  CAS  Google Scholar 

  15. Walker, J.S., R.B. Sheather-Reid, J.J. Carmody, J.H. Vial, and R.O. Day. 1997. Nonsteroidal antiinflammatory drugs in rheumatoid arthritis and osteoarthritis: support for the concept of “responders” and “nonresponders” Arthritis Rheum. 40:1944–1954.

    Article  PubMed  CAS  Google Scholar 

  16. Furst, D.E. 1994. Are there differences among nonsteroidal antiinflammatory drugs? Comparing acetylated salicylates, nonacetylated salicylates, and nonacetylated nonsteroidal antiinflammatory drugs. Arthritis Rheum. 37(1):1–9.

    Article  PubMed  CAS  Google Scholar 

  17. Crofford, L.J., P. Lipsky, P. Brooks, S.B. Abramson, L.S. Simon, L.B.A. van de Putte. 2000. Basic biology and clinical application of cyclooxygenase-2. Arthritis Rheum. 43:4–13.

    Article  PubMed  CAS  Google Scholar 

  18. Dubois, R.N., S.B. Abramson, L. Crofford, R. Gupta, L.S. Simon, L.B. Van De Putte, P.E. Lipsky. 1998. Cyclooxygenase in biology and disease. FASEB. J. 12:1063–1073.

    PubMed  CAS  Google Scholar 

  19. Mitchell, J.A., P. Akarasereenont, C. Thiemermann, R.J. Flower, and J.R. Vane. 1994. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 90:11,

    Google Scholar 

  20. Mitchell, J.A., P. Akarasereenont, C. Thiemermann, R.J. Flower, and J.R. Vane. 1994. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 693–11,697.

    Google Scholar 

  21. Bensen, W.G., J.J. Fiechtner, J.I. McMillen, W.H. Zhao, S.S. Yu, E.M. Woods, et al. 1999. Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhbitor: A randomized controlled trial Mayo Clin. Proc. 1999; 74:1095–1105.

    Article  PubMed  CAS  Google Scholar 

  22. Ehrich, E.W., A. Dallob, I. De Lepeleire, A. Van Hecken, D. Riendeau, W. Yuan W, et al. Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model. Clin. Pharmacol. Ther. 1999;65:336–347.

    Article  PubMed  CAS  Google Scholar 

  23. Schnitzer, T.J., M. Kamin, and W.H. Olson. 1999. Tramadol allows reduction of naproxen dose among patients with naproxen-responsive osteoarthtis pain: a randomized, double blind, placebo controlled trial. Arthritis Rheum. 42:1370–1377.

    Article  PubMed  CAS  Google Scholar 

  24. Simon, L.S. 1996. Nonsteroidal antiinflammatory drugs and their effects: the importance of COX selectivity. J. Clin. Rheum. 2:135–140.

    Article  CAS  Google Scholar 

  25. Simchowitz, L., J. Mehta, and I. Spilberg. 1979. Chemotactic factor-induced generation of superoxide radicals by human neutrophils: effect of metabolic inhibitors and antiinflammatory drugs. Arthritis Rheum. Jul ;22(7):755–763.

    Article  CAS  Google Scholar 

  26. Goodwin, J.S. 1984. Immunologic effects of nonsteroidal anti-inflammatory drugs. Am. J. Med. Oct 15;77(4B):7–15.

    PubMed  CAS  Google Scholar 

  27. Diaz-Gonzalez, F., I. González-Alvero, M.R. Companero, et al. Prevention of in vitro neutrophilendothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs. J. Clin. Invest. 1995; 95(4):1756–1765.

    Article  PubMed  CAS  Google Scholar 

  28. Amin, A.R., P. Vyas, M. Attur, J. Leszczynska-Piziak, I.R. Patel, G. Weissmann, and S.B. Abramson. 1995. The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc. Natl. Acad. Sci. USA 92:7926–7930.

    Article  PubMed  CAS  Google Scholar 

  29. Bombardier, C., P.M. Peloso, and C.H. Goldsmith. 1995. Salsalate, a nonacetylated salicylate, is as efficacious as diclofenac in patients with rheumatoid arthritis. Salsalate-diclofenac study group. I. Rheumatol. 22:617–624.

    CAS  Google Scholar 

  30. Agrawal, N.M., J. Caldwell, A.J. Kivitz, et al. 1999. Comparison of the upper gastrointestinal safety of Arthrotec 7 and nabumetome in osteoarthritis patients at high risk for developing nonsteroidal anti-inflammatory drug-induced gastrointestinal ulcers. Clin. Ther. April; 21(4):659–674.

    Article  PubMed  CAS  Google Scholar 

  31. Simon, L.S., C. Basch, and D. Robinson. 1991. Naproxen levels in plasma and synovial fluid of patients with rheumatoid arthritis. Curr. Therapeut. 13(supp.) 4:35–43.

    Google Scholar 

  32. Garcia Rodriguez, L.A., R. Williams, L.E. Derby, A.D. Dean, and H. Jick. 1994. Acute liver injury asociated with nonsteroidal antiinflammatory drugs and the role of risk factors. Arch. Intern. Med. 154:311–316.

    Article  PubMed  CAS  Google Scholar 

  33. Helfgott, S.M., J. Sandberg-Cook, D. Zakim, and J. Nestler. 1990. Diclofenac-associated hepatotoxicity. JAMA 264:2660–2662.

    Article  PubMed  CAS  Google Scholar 

  34. Simon, L.S. 1996. Actions and toxicities of the NSAIDs. Curr. Opin. Rheum. 8:169–175.

    Article  CAS  Google Scholar 

  35. Robinson, D.R., M. Skoskiewicz, K.J. Bloch, G. Castorena, et al. 1986. Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep. J. Exp. Med. Jun 1;163(6):1509–1517.

    Article  PubMed  CAS  Google Scholar 

  36. Wolfe, M.M., D.R. Lichtenstein, and G. Singh. 1999. Gastrointestinal toxicity of the nonsteroidal antiinflammatory drugs. N. Engl. J. Med. 340:1888–1899.

    Article  PubMed  CAS  Google Scholar 

  37. Bjarnson, I., J. Hyllar, A.J. Macpherson, and A.S. Russell. 1993. Side effects of the nonsteroidal anitinflammatory drugs on small and large intestine. Gastroenterology 104:1832–1847.

    Google Scholar 

  38. Fries, J.P., S.R. Miller, and P.W. Spitz. 1989. Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use. Gastroenterology 96:647–655.

    PubMed  CAS  Google Scholar 

  39. Gabriel, S.E., L. Jaaklimainen, and C. Bombadier. Risk for serious gastrointestinal complications related to use of nonsteroidal antiinflammatory drugs: a meta-analysis. Ann. Int. Med. 1991; 115:787–796.

    PubMed  CAS  Google Scholar 

  40. Allison, M.C., A.G. Howatson, and C.J. Torance. 1992. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N. Engl. J. Med. 327:749–754.

    Article  PubMed  CAS  Google Scholar 

  41. Silverstein, F.E., D.Y. Graham, J.R. Senior, et al. 1995. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. Ann. Intern. Med. 123:214

    Google Scholar 

  42. Griffin, M.R., J.M. Piper, J.R. Daugherty, M. Snowden, and W.A. Ray. 1991. Nonsteroidal antiinflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann. Intern. Med. 114:257–263.

    PubMed  CAS  Google Scholar 

  43. Langman, M.J., D.M. Jensen, D.J. Watson, S.E. Harper, P.L. Zhao, H. Quan, et al. 1999. Adverse upper gastrointestinal effects of rofecoxib compared with NSIADs. JAMA 282:1929–1933.

    Article  PubMed  CAS  Google Scholar 

  44. Scheiman, J.M. and L. Laine. 1996. Nonsteroidal antiinflammatory drug gastropathy. Gastrointet. Endosc. Clin. North. Am. 6:489–504.

    Google Scholar 

  45. Singh, G., D.R. Ramey, D. Morfeld, H. Shi, H.T. Hatoum, and J.F. Fries. 1996. Gastrointestinal tract complications of nonsteroidal antiinflammaotry drug treatment in rheumatoid arthritis. A prospective observational study. Arch. Intern. Med. 156:1530–1536.

    Article  PubMed  CAS  Google Scholar 

  46. Simon, L.S., H.T. Hatoum, R.M. Bittman, W.T. Archambault, and R.P. Polisson. 1996. Risk factors for serious nonsteroidal-induced gastrointestinal complications: regression analysis of the MUCOSA trial. Fam. Med. 28:202–208.

    Google Scholar 

  47. Graham, D.Y., R.H. White, L.W. Moreland, et al. 1993. Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs. Ann. Intern. Med. 119:257–262.

    PubMed  CAS  Google Scholar 

  48. Taha, A., N. Hudson, C.J. Hawkey, A.J. Swannell, P.N. Trye, J. Cottrell, et al. 1996. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammaotry drugs. N. Engl. J. Med. 334:1435–1439.

    Article  PubMed  CAS  Google Scholar 

  49. Hawkey, C.J., J.A. Karrasch, L. Szczepanski, D.G. Walker, A. Barkun, A.J. Swannell, et al. 1998. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. N. Engl. J. Med. 338: 727–734.

    Article  PubMed  CAS  Google Scholar 

  50. McAdam, B.F., F. Catella-Lawson, I.A. Mardini, S. Kapoor, J.A. Lawson, and G.A. Fitz Gerald. 1999. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc. Natl. Acad. Sci. USA May 11;96(10):5890.

    CAS  Google Scholar 

  51. Patrono, C. and M.J. Dunn. 1987. The clinical significance of inhibition of renal prostaglandin synthesis. Kid. Int. 32:1.

    Article  CAS  Google Scholar 

  52. Saag, K.G., L.M. Rubenstein, E.A. Chrischilles, and R.B. Wallace. 1995. Nonsteroidal antiinflammatory drugs and cognitive decline in the elderly. J. Rheumatol. 22: 2142–2147.

    PubMed  CAS  Google Scholar 

  53. Simon, L.S. 1998. Biology and toxic effects of nonsteroidal anti-inflammatory drugs. Curr. Opin. Rheumatol. May 10(3):153–158.

    Article  PubMed  CAS  Google Scholar 

  54. Nilsson, OS and P.E. Persson. 1999. Heterotopic bone formation after joint replacement. Curr. Opin. Rheumatol. 11:127–131.

    Article  PubMed  CAS  Google Scholar 

  55. Huskisson, E.C., H. Berry, P. Gishen, R.W. Jubb, and J. Whitehead. 1995. Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal investigation of nonsteroidal anti-inflammatory drugs in knee osteoarthritis. J. Rheumatol. 22:1941–1946.

    PubMed  CAS  Google Scholar 

  56. Amin, A.R., M. Attur, R.N. Patel, G.D. Thakker, P.J. Marshall, et al. 1997. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. J. Clin. Invest. Mar 15;99(6):1231–1237.

    Article  PubMed  CAS  Google Scholar 

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Husni, M.E., Simon, L.S. (2002). Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs. In: Tsokos, G.C. (eds) Modern Therapeutics in Rheumatic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-239-5_4

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  • DOI: https://doi.org/10.1007/978-1-59259-239-5_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9708-3

  • Online ISBN: 978-1-59259-239-5

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