Retinoblastoma Protein in Growth Control and Differentiation

  • Lilia Stepanova
  • J. Wade Harper
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Proper development of multicellular organisms from a single cell requires precise control of cellular proliferation, differentiation, and apoptosis. This multistep control involves a complex interplay between numerous genes regulating spatial and temporal aspects of development and proliferation. Defects in these control mechanisms can lead to developmental defects or tumor formation. Research performed over the past decade has brought us closer to an understanding of how a family of critical growth regulators, typified by the retinoblastoma (RB) tumor suppressor gene (Rb), function to control cell proliferation and differentiation.


Retinoblastoma Protein Tumor Suppressor Pathway Muscle Cell Differentiation Pocket Protein Retinoblastoma Gene Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Lilia Stepanova
  • J. Wade Harper

There are no affiliations available

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