Abstract
Adhesion to host tissues enables human pathogens to withstand host defense mechanisms such as removal by fluid flow, mucociliary clearance, and other physical processes. Adhesion is therefore an essential prerequisite for successful colonization of epithelial surfaces and is recognized as a virulence factor for bacterial, viral and fungal pathogens. However, adhesion alone is rarely, if ever, responsible for inducing disease. Most frequently, the combination of adhesion, pathogen growth in the lining epithelial cells, and toxin production or adhesion, penetration, and growth within mucosal epithelial cells determines the course of human diseases.
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Plotkowski, M.C., de Bentzmann, S., Puchelle, E. (2000). Studying Bacterial Adhesion to Respiratory Mucosa. In: An, Y.H., Friedman, R.J. (eds) Handbook of Bacterial Adhesion. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-224-1_29
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