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Prolactin in Human Breast Cancer Development

  • Barbara K. Vonderhaar
Part of the Contemporary Endocrinology book series (COE)

Abstract

In order to establish a role for a hormone in breast cancer (BC), three criteria must first be met: Specific receptors must be present in or on human BC cells, human BC cells must respond to the hormone as a mitogen, and a clinical response must be achieved when the hormone is prevented from binding to its receptors or following hormone ablation. In the case of estrogen, these three criteria have been met, and its role in human BC is widely accepted. However, the case for prolactin (PRL) has not been widely accepted, because the third criterion has been difficult to satisfy. Recent evidence from the author’ s and others’ laboratories has presented a possible explanation that accounts for the difficulty in establishing the third criterion: Human BC cells synthesize and secrete their own biologically active PRL. This review examines the three criteria, in order to establish the validity of a potential role of PRL in human BC, and to explore possible implications in management of the disease.

Keywords

Breast Cancer Breast Cancer Mammary Gland Mammary Gland Development Prolactin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Humana Press Inc., Totowa, NJ 2000

Authors and Affiliations

  • Barbara K. Vonderhaar

There are no affiliations available

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