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Fibroblast Growth Factors and Their Receptors in Breast and Prostate Cancer

  • R. C. Coombes
  • S. Marsh
  • J. Gomm
  • C. Johnston
Part of the Contemporary Endocrinology book series (COE)

Abstract

The fibroblast growth factor (FGF) family has emerged as perhaps the largest group of polypeptide growth factors to be involved in cellular growth and differentiation. It presently comprises more than 20 published members that share a varying degree of homology, and, with the exception of FGF7 and FGF10, which specifically act on epithelial cells (ECs), have a similar broad mitogenic spectrum, i.e., they promote the proliferation of a variety of cells, including those of mesodermal origin, and are angiogenic. With the exception of FGF8, their genes have similar organization and, in some cases, map to comparable regions on human and mouse chromosomes. Their pattern of expression is very different, ranging from restricted expression in some stages of development, e.g., FGF3, FGF4, and FGF5, to rather ubiquitous expression in a variety of tissues and organs, in the cases of FGF1 and FGF2. They all appear to bind heparin and heparan sulphate proteoglycans (HSPG) in the extracellular matrix, which originally led to their alternative grouping, as the heparin-binding growth factors (1).

Keywords

Breast Cancer Fibroblast Growth Factor Fibroblast Growth Factor Receptor Basic Fibroblast Growth Factor Mouse Mammary Tumor Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Humana Press Inc., Totowa, NJ 2000

Authors and Affiliations

  • R. C. Coombes
  • S. Marsh
  • J. Gomm
  • C. Johnston

There are no affiliations available

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