Insulin-Like Growth Factors and Endocrine Neoplasia

  • Douglas Yee
  • Adrian V. Lee
Part of the Contemporary Endocrinology book series (COE)


The observation that breast (BC) and prostate cancer (PC) are regulated by sex hormones provided a paradigm for treatment of these diseases (1,2). Despite the accumulation of multiple genetic abnormalities, the cancer cell is still responsive to extracellular signals that were previously required for normal growth and development of the organ. Blockade of steroid hormone receptors, or inhibition of the synthesis of the ligands for the receptors, are successful and relatively nontoxic therapeutic modalities for treatment of virtually all stages of BC and PC (3,4). Thus, it is a worthwhile effort to define other growth regulatory pathways important for cancer cells, with the long-term goal of developing additional specific therapies. This chapter discusses the evidence that the insulinlike growth factors (IGFs) regulate cancer cell growth, and that strategies directed at inhibition of IGF action could be useful therapeutic strategies for cancer treatment.


Human Breast Cancer Cell 
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© Humana Press Inc., Totowa, NJ 2000

Authors and Affiliations

  • Douglas Yee
  • Adrian V. Lee

There are no affiliations available

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