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The Wnt Signal Transduction Pathway

  • Chapter
Signaling Networks and Cell Cycle Control

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Wnt signaling plays a central role in the development of many phylogenetically diverse organisms including Drosophila, Caenorhabditis elegans, Xenopus, and higher vertebrates. In addition, genetic alterations of components in the pathway are associated with tumorigenesis in mice and humans, particularly melanomas and carcinomas of the breast and colon. This chapter reviews the characteristics of individual components of the pathway and discusses some of its unresolved issues.

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  1. Grant D. Barish BS
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  1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    J. Silvio Gutkind PhD

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Barish, G.D., Williams, B.O. (2000). The Wnt Signal Transduction Pathway. In: Gutkind, J.S. (eds) Signaling Networks and Cell Cycle Control. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-218-0_4

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