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Signaling Networks and Cell Cycle Control pp 213–230Cite as

Ras Signaling and Transformation

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The Ras proto-oncogene proteins are the founding members and prototypes for a large superfamily of small GTPases whose mammalian members now number more than 70. At least seven distinct branches can be defined on the basis of sequence identity and protein function: Ras, Rab, Rho, Ran, Gem/Rad, Rit/Rin, Rheb, and Arf/Arl. The Ras family includes the three Ras proteins (H-Ras, N-Ras and K-Ras4A/4B), as well as the closely related (~50% amino acid identity) Rap (1A, 1B, 2A, and 2B), Ral (lA and IB), and R-Ras (R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3) proteins (1–3).

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Authors
  1. Geoffrey J. Clark
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  2. John P. O’Bryan
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  3. Channing J. Der
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Editor information

Editors and Affiliations

  1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    J. Silvio Gutkind PhD

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© 2000 Humana Press Inc., Totowa, NJ

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Clark, G.J., O’Bryan, J.P., Der, C.J. (2000). Ras Signaling and Transformation. In: Gutkind, J.S. (eds) Signaling Networks and Cell Cycle Control. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-218-0_12

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  • DOI: https://doi.org/10.1007/978-1-59259-218-0_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9695-6

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