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Molecular Mechanism of Biomaterial-Mediated Phagocyte Responses

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Biomaterials Engineering and Devices: Human Applications

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Abstract

In both blood-contact and tissue-contact situations, biomaterial surfaces are covered with substantial numbers of adherent phagocytes shortly after implantation. These adherent phagocytes are actively involved in the pathogenesis of a variety of biomaterial-associated adverse reactions, including inflammation surrounding many types of implants (1–7); implant degradation and stress cracking (8–12); tissue fibrosis surrounding mammary prostheses, joint implants, and many other types of implants (13–19); and device-centered infection (20–22). Such adverse responses to bio-materials may lead to implant failures and, sometimes, fatality.

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Authors
  1. Liping Tang
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Editors and Affiliations

  1. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Donald L. Wise PhD

  2. Cambridge Scientific, Inc., Cambridge, MA, USA

    Joseph D. Gresser PhD , Debra J. Trantolo PhD  & Mario V. Cattaneo PhD ,  & 

  3. Massachusetts General Hospital, Boston, MA, USA

    Kai-Uwe Lewandrowski MD

  4. Mayo Clinic, Rochester, MN, USA

    Michael J. Yaszemski MD, PhD

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© 2000 Springer Science+Business Media New York

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Tang, L. (2000). Molecular Mechanism of Biomaterial-Mediated Phagocyte Responses. In: Wise, D.L., Gresser, J.D., Trantolo, D.J., Cattaneo, M.V., Lewandrowski, KU., Yaszemski, M.J. (eds) Biomaterials Engineering and Devices: Human Applications . Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-196-1_1

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  • DOI: https://doi.org/10.1007/978-1-59259-196-1_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-226-1

  • Online ISBN: 978-1-59259-196-1

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