Skip to main content

Molecular Genetics and Cancer Screening

Current Status and Future Prospects

  • Chapter
Cancer Screening

Part of the book series: Current Clinical Practice ((CCP))

  • 115 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Watson JD, Crick FHC. (1953) A structure for deoxyribose nucleic acid. Nature 171: 737, 738.

    Google Scholar 

  2. Neuhausen S. (1999) Ethnic differences in cancer risk resulting from genetic variation. Cancer 86 (8): 1755–1762.

    Article  Google Scholar 

  3. Webb MJ. (1998) Symposium: genetic testing and management of the cancer patient and cancer families. J Am Coll Surg 187(41):449–456.

    PubMed  CAS  Google Scholar 

  4. Weitzel JN. (1999) Genetic cancer risk assessment. Cancer 86 (8): 1663–1672.

    Article  Google Scholar 

  5. Lynch HT, et al. (1999) Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Cancer 86 (8): 1629–1636.

    Article  Google Scholar 

  6. Gelehrter TD, et al. (1998) Principles of Medical Genetics. Baltimore, MD: Williams and Wilkins.

    Google Scholar 

  7. Heppner C, Reincke M, Agarwalsk, et al. (1999) MEN1 gene analysis in sporadic adrenocortical neoplasms. J Clin Endo Meta 84(11):216–219.

    Article  CAS  Google Scholar 

  8. Knudson AG. (1996) Hereditary cancer:Two hits revisited. J CancerRes Clin Oncol 122 (3): 135–140.

    Article  CAS  Google Scholar 

  9. Leach FS, Nicolaides NC, Papadopoulos N, et al. (1993) Mutation of a MutS homologue in hereditary non-polyposis colorectal cancer. Cel175:1215–1225.

    Google Scholar 

  10. Nystrrom-Lahti M, Parson R, Sistonen P, et al. (1994) Mismatch repair genes on chromosome 2p and 3p account for a major share of hereditary non-polyposis colorectal cancer families evaluated by linkage. Am J Hum Genet 55: 659–665.

    Google Scholar 

  11. Rebbeck TR. (1999) Inherited genetic predisposition in breast cancer-a population-based perspective. Cancer 86 (8): 1673–1681.

    Article  Google Scholar 

  12. Gauthier-Villars M, et al. (1999) Genetic testing for breast cancer predisposition. Breast Cancer Manag 79(5):1 171–1 187.

    CAS  Google Scholar 

  13. Gayther SA, et al. (1995) Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for genotype-phenotype correlation. Nat Genet 11: 428–433.

    Article  PubMed  CAS  Google Scholar 

  14. Hughes KS, et al. (1999) Prophylactic mastectomy and inherited predisposition to breast carcinoma. Cancer 86 (8): 1682–1696.

    Article  Google Scholar 

  15. Berchuck A, et al. (1999) Managing hereditary ovarian cancer risk. Cancer 86 (8): 1697–1704.

    Article  Google Scholar 

  16. Petersen GM, et al. (1999) Genetic testing and counseling for hereditary forms of colorectal cancer. Cancer 86 (8): 1720–1730.

    Article  Google Scholar 

  17. Powell SM, et al. (1993) Molecular diagnosis of familial adenomatous polyposis. N Engl J Med 329: 1982–1987.

    Article  PubMed  CAS  Google Scholar 

  18. Green MH. (1999) The genetics of hereditary melanoma and nevi. Cancer 86 (8): 1644–1657.

    Google Scholar 

  19. Cannon-Albright IA, et al. (1994) Localization of the 9p melanoma susceptibility locus (MLM) to a 2-cM region between D9S726 and D9S 171. Genomics 23: 265–268.

    Article  PubMed  CAS  Google Scholar 

  20. Cannon-Albright IA, et al. (1994) Penetrance and expressivity of the chromosome 9p melanoma susceptibility locus (MLM). Cancer Res 54: 6041–6044.

    PubMed  CAS  Google Scholar 

  21. Kamb GA, et al. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436–440.

    Article  PubMed  CAS  Google Scholar 

  22. Wolfel HT, et al. (1995) A pl 6INK4a in sensitive CDK4 mutant targeted by cytotoxic T-cells in a human melanoma. Science 269: 1281–1284.

    Article  PubMed  CAS  Google Scholar 

  23. Calender A. (1998) genetic testing in multiple endocrine neoplasia and related syndromes. Forum (Genova) 8(2):146–159.

    PubMed  CAS  Google Scholar 

  24. Wohllk N, et al. (1996) Application of genetic screening information to the management of medullary thyroid carcinoma and multiple endocrine neoplasia type 2. Endo Metabol Clin 25 (1): 1–25.

    Article  CAS  Google Scholar 

  25. Ilipoulos KO, et al. (1995) Tumor suppressor by the human von Hippel-Lindau gene product. Nat Med 1:822–826.

    Article  Google Scholar 

  26. Duan, DR, et al. (1995) Inhibition of transcriptional elongation by the VHL tumor suppressor protein. Science 269: 1402–1406.

    Article  PubMed  CAS  Google Scholar 

  27. Seizinger BR, et al. (1988) von Hippel Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 332:268,269.

    Article  Google Scholar 

  28. Friedrich CA. (1999) von Hippel Lindau syndrome—a pleomorphic condition. Cancer 86(8):1658–1662.

    Article  Google Scholar 

  29. Bondy M, et al. (1997) Ethical issues of genetic testing and their implications in epidemiological studies. Ann Epidemiol 7: 363–366.

    Article  PubMed  CAS  Google Scholar 

  30. Parker LS, et al. (1996) Standards of care and ethical concerns in genetic testing and screening. Clin Obstet Gynnocol 9 (4): 873–884.

    Article  Google Scholar 

  31. White MT, et al. (1999) Genetic testing for disease susceptibility: social, ethical and legal issues for family physicians. Am Fam Physician 60 (3): 748–755.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ling, Z., Aziz, K., Wu, G.Y. (2002). Molecular Genetics and Cancer Screening. In: Aziz, K., Wu, G.Y. (eds) Cancer Screening. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-191-6_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-191-6_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-229-2

  • Online ISBN: 978-1-59259-191-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics