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Handbook of Neurotoxicology pp 3–56Cite as

Developmental Neurotoxicology

Testing and Interpretation

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Abstract

Developmental neurotoxicology is the study of adverse effects on the nervous system resulting from exposure to a toxicant during development. The scientific discipline of developmental neurotoxicology integrates the principles and methods of neurotoxicology with those of developmental toxicology; concepts and techniques from developmental neuroanatomy, neurobiology, and experimental psychology are also highly applicable. In addition, developmental neurotoxicology research over the past 50 years has led to concepts and methodologies unique to this discipline. The developing nervous system is highly susceptible to toxic insult, and exposure to toxic agents may result in adverse effects at doses lower than those required to produce the same effect in adults (1). Enhanced sensitivity of the developing nervous system (in particular the central nervous system [CNS]) to disruption is due to factors such as a prolonged course of development, immaturity of the blood-brain barrier (BBB), and lack of regeneration of damaged CNS neurons. One of the more insidious aspects of developmental neurotoxicity is that its functional manifestations may not be readily apparent at birth or in infancy, but rather, become evident during adulthood when the nervous system is mature and possibly even senescent.

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  1. Judith W. Henck
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    Edward J. Massaro

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Henck, J.W. (2002). Developmental Neurotoxicology. In: Massaro, E.J. (eds) Handbook of Neurotoxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-165-7_1

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