Abstract
During the 1960s, many pharmaceutical companies around the world were involved in the study of the structure-activity relationships of the antiestrogens. Each compound was an effective antifertility agent in the laboratory rat, but it was clear that the properties scientists were observing in animals did not translate into a clinically useful contraceptive. A number of preliminary clinical trials in breast cancer were conducted with several new antiestrogens because of the recognized link between estrogen and the growth of some breast cancers (1,2). It had also been found in the laboratory that antiestrogens could block the binding of radioactive estradiol in its target tissues, so the rationale for clinical studies in the 1970s was strong.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Beatson GT. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet 1896; ii:104–107.
Boyd S. On oophorectomy in cancer of the breast. BMJ 1900; 2:1161–1167.
Bloom HJG, Biesen E. Antiestrogens in the treatment of breast cancer. Value of raloxidine in 52 advanced cases. BMJ 1974; 2:7–14.
Legha SS, Carter SK. Antiestrogen in the treatment of breast cancer. Cancer Treat Rev 1976; 3:205–216.
Jordan VC. The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur Walpole. Breast Cancer Res Treat 1988; 11:197–209.
Cole MP, Jones CTA, Todd IDH. A new antioestrogenic agent in late breast cancer. An early appraisal of ICI 46, 474. Br J Cancer 1971; 25:270–275.
Ward HWC. Antioestrogenic therapy for breast cancer: a trial of tamoxifen at two dose levels. BMJ 1973; 1:13–14.
Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med 1998; 339:1609–1618.
Early Breast Cancer Trialists’ Collaborative Group Tamoxifen for early breast cancer: an overview of the randomized trials. Lancet 1998; 351:1451–1467.
Jordan VC, Jaspan T. Tamoxifen as an antitumour agent: estrogen binding as a predictive test for tumour response. J Endocrinol 1976; 68:453–460.
Jordan VC. Antitumour activity of the antiestrogen ICI 46, 474 (tamoxifen) in the dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma model. J Steroid Biochem 1974; 5:354.
Jordan VC. Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata. Eur J Cancer 1976; 12:419–424.
Jordan VC, Dix CJ, Allen KE. The effectiveness of long term tamoxifen treatment in a laboratory model for adjuvant hormone therapy of breast cancer, in Adjuvant Therapy of Cancer II (Salmon SE, Jones SE, eds). Grune & Stratton New York, NY Inc., 1979, pp 19–26.
Jordan VC, Allen KE. Evaluation of the antitumour activity of the nonsteroidal antiestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model. Eur J Cancer 1980; 16:239–251.
Jordan VC. Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications. Breast Cancer Res Treat 1983; 3, pp 73–86.
Satyaswaroop PG, Zaino RJ, Mortel R. Estrogen-like effects of tamoxifen on endometrial carcinoma transplanted in nude mice. Cancer Res 1984; 44:4006–4010.
Gottardis MM, Robinson SP, Satyaswaroop PG, Jordan VC. Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Res 1988; 48:812–815.
MacGregor JI, Jordan VC. Basic guide to the mechanisms of antiestrogen action. Pharm Rev 1998; 50:151–196.
Early Breast Cancer Trialists’ Collaborative Group. The effects of adjuvant tamoxifen and of cytotoxic chemotherapy on mortality in early breast cancer: an overview of 61 randomized trials among 28,896 women. N Engl J Med 1988; 319:1681–1692.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Humana Press, a part of Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Jordan, V.C. (2009). Tamoxifen for the Treatment of Breast Cancer. In: Jordan, V.C., Furr, B.J. (eds) Hormone Therapy in Breast and Prostate Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59259-152-7_8
Download citation
DOI: https://doi.org/10.1007/978-1-59259-152-7_8
Publisher Name: Humana Press
Print ISBN: 978-1-60761-471-5
Online ISBN: 978-1-59259-152-7
eBook Packages: Springer Book Archive