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Marine Mammals as Sentinels of Environmental Biotoxins

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Handbook of Neurotoxicology
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Abstract

Harmful algal blooms (HABs), commonly known as “red tides,” are documented in almost every coastal region of the world. Over the past decade, these toxic blooms appear to have increased in number, magnitude, and seasonal duration, potentially due to the spread of toxic algal species to new areas, eutrophication caused by human development of coastal areas, and global climate change Some of the microscopic, single-celled algae that constitute the base of the marine food chain produce the potent toxins found in these harmful blooms. These toxins can accumulate in fish, shellfish, and other marine organisms, and move through the food chain, at times affecting the highest consumers, including marine mammals and humans. Humans are usually well-protected by federal and state monitoring programs that detect the toxins at an early stage and restrict the harvest or sale of the toxic seafood. However, marine mammal health is not protected by the same routine monitoring programs. Recent evidence has indicated that mass mortalities and strandings of whales, dolphins, sea lions, manatees, and sea otters, in some cases, may be caused by their exposure to marine biotoxins.

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References

  1. Gunter, G., Williams, R. H., Davis, C. C., and Smith F. G. W. (1948) Catastrophic mass mortality of marine animals and coincident phytoplankton bloom on the west coast of Florida, November 1946 to August 1947. Ecolog. Monogr. 18, 309 - 324.

    Google Scholar 

  2. Tracey, G. A. (1998) Feeding reduction, reproductive failure, and mortality in Mytilus edulis during the 1985 "brown tide" in Narragansett Bay, Rhode Island. Mar. Ecol. Prog. Ser. 50, 73 - 81.

    Article  Google Scholar 

  3. Dennison, W. C., Marshal, G. J., and Wigand, C. (1989) Effect of `brown tide' shading on eelgrass (Zostera marine L.) distributions, in Novel Phytoplankton Blooms: Causes and Impacts of Recurrent Brown Tides and Other Unusual Blooms. Coastal and Estuarine Studies, vol. 35 ( Cosper, E. M., Bricelj, V. M., and Carpenter, E. J., eds.), Springer Verlag, Berlin, pp. 675 - 692.

    Google Scholar 

  4. Burkholder, J. M., Noga, E. J., Hobbs, C. H., and Glasgow, Jr., H. B. (1992) New "phantom" dinoflagellate is the causative agent of major estuarine fish kills. Nature 358, 407 - 410.

    Article  PubMed  CAS  Google Scholar 

  5. Taylor, F. J. R. (1993) Current problems with harmful phytoplankton blooms in British Columbia waters, in Toxic Phytoplankton Blooms in the Sea ( Smayda, T. J. and Shimizu Y., eds.), Elsevier Science,. Amsterdam, pp. 699 - 703.

    Google Scholar 

  6. Landsberg, J. H. (1995) Tropical reef-fish disease outbreaks and mass mortalities in Florida, USA: what is the role of dietary biological toxins? Dis. Aquat. Org. 22, 83 - 100.

    Article  Google Scholar 

  7. Landsberg, J. H., Balazs, G. H., Steidinger, K. A., Baden, D. G., Work, T. M., and Russell, D. J. (1999) The potential role of natural tumor promoters in marine turtle fibropapillomatosis. J. Aq. Animal Health 11, 199 - 210.

    Article  Google Scholar 

  8. Scholin, C.A., Gulland, F., Doucette, G. J., Benson, S., Busman, M., Chavez, et al. (2000) Mortality of sea lions along the central California coast linked to a toxic diatom bloom. Nature 403, 80 - 84.

    Google Scholar 

  9. Hall, S., Strichartz, G. R., Moczydlowski, E., Ravindran, A., and Reichardt, P. B. (1990) The saxitoxins: sources, chemistry, and pharmacology, in Marine Toxins (Hall, S. and Strichartz, G. R., eds.), ACS Symposium Series 418. American Chemical Society Washington, DC, pp. 29 - 65.

    Google Scholar 

  10. Baden, D. G. and Trainer, V. L. (1993) Mode of action of toxins of seafood poisoning, in Algal Toxins in Seafood and Drinking Water (Falconer, I. R., ed.), Academic Press, New York, pp. 49 - 74.

    Google Scholar 

  11. Hernandez, M., Robinson, I., Aguilar, A., Gonzalez, L. M., Lopez-Jurado, L. F., Reyero, M. I., et al. (1998) Did algal toxins cause monk seal mortality? Nature 393, 28 - 29.

    Google Scholar 

  12. DeGange, A. R. and Vacca, M. M. (1989) Sea otter mortality at Kodiak Island, Alaska, during summer 1987. J. Mammol. 70 (4), 836 - 838.

    Article  Google Scholar 

  13. Layne, J. N. (1965) Observations on marine mammals in Florida waters. Bull. Fl. State Mus. 9, 131 - 181.

    Google Scholar 

  14. O'Shea, T. J., Rathbun, G. B., Bonde, R. K., Buergelt, C. D., and Odell, D. K. (1991) An epizootic of Florida manatees associated with a dinoflagellate bloom. Mar. Mamm. Sci. 7 (2), 165 - 179.

    Article  Google Scholar 

  15. Landsberg, J. H. and Steidinger, K. A. (1998) A historical review of Gymnodinium breve red tides implicated in mass mortalities of the manatee (Trichechus manatus latirostris) in Florida, USA, in Harmful Algae ( Reguera, B., Blanco, J., Fernandez, M. L., and Wyatt, T., eds.), UNESCO, Paris, pp. 97 - 100.

    Google Scholar 

  16. Bossart, G. D., Baden, D. G., Ewing, R. Y., Roberts, B., and Wright, S. D. (1998) Brevetoxicosis in manatees (Trichechus manatus latirostris) from the 1996 epizootic: gross, histologic, and immunohistochemical features. Toxicol. Path. 26, 276 - 282.

    Article  CAS  Google Scholar 

  17. Steidinger, K. A., Burklew, M. A., and Ingle, R. M. (1973) The effects of Gymnodinium breve toxin on estuarine animals, in Marine Pharmacognosy: Action of Marine Toxins at the Cellular Level ( Martin, D. F. and Padilla, G. M., eds.), Academic Press, New York, pp. 179 - 202.

    Google Scholar 

  18. Steidinger, K. A. and Haddad, K. (1981) Biologic and hydrographic aspects of red tides. Bioscience 31, 814 - 819.

    Article  Google Scholar 

  19. Baden, D. G. and Mende, T. J. (1982) Toxicity of two toxins from the Florida red tide marine dinoflagellate, Gymnodinium breve. Toxicon 20, 457 - 461.

    Article  CAS  Google Scholar 

  20. Pierce, R. H. (1986) Red tide (Gymnodinium breve) toxin aerosols: a review. Toxicon 24, 955 - 965.

    Article  PubMed  CAS  Google Scholar 

  21. Geraci, J. R. (1989) Clinical investigation of the 1987-88 mass mortality of bottlenose dolphins along the U.S. central and south Atlantic coast. Final report to National Marine Fisheries Service, U.S. Navy, Office of Naval Research, and Marine Mammal Commission, pp. 63.

    Google Scholar 

  22. Scott, G. P., Burn, D. M., and Hansen, L. J. (1988) The dolphin dieoff: long-term effects and recovery of the population. Proceedings Oceans '88, Baltimore, MD. pp, 819 - 823.

    Google Scholar 

  23. Baden, D. G. (1983) Marine food-borne dinoflagellate toxins. Int. Rev. Cytol. 82, 99 - 150.

    Article  PubMed  CAS  Google Scholar 

  24. Geraci, J. R., Anderson, D. M., Timperi, R. J., St. Aubin, D. J., Early, G. A., Prescott, J. H., and Mayo, C. A. (1989) Humpback whales (Megaptera novaeangliae) fatally poisoned by dinoflagellate toxin. Can. J. Fish. Aquat. Sci. 46, 1895 - 1898.

    Google Scholar 

  25. Gulland, F., et al. (2000) Domoic acid toxicity in California sea lions (Zalophus californicus) stranded along the central California coast, May-October 1998. Report to the National Marine Fisheries Service Working Group on Unusual Marine Mortality Events. US Dept. of Commerce, NOAA Tech. Memo. NMFS-OPR-17, 45 p.

    Google Scholar 

  26. Lefebvre, K. A., Powell, C. L., Doucette, G. J., Silver, J. B., Miller, P. E., Hughes, M. P., et al. (1999) Detection of domoic acid in northern anchovies and California sea lions associated with an unusual mortality event. Nat. Toxins 7, 85 - 92.

    Article  PubMed  CAS  Google Scholar 

  27. Trainer, V. L., Adams, N. G., Bill, B. D., Stehr, C. M., Wekell, J. C., Moeller, P., et al. (2000) Domoic acid production near California coastal upwelling zones, June 1998. Limnol. Oceanogr. 45 (8), 401 - 440.

    Article  Google Scholar 

  28. Xi, D., Peng, Y. G., and Ramsdell, J. S. (1997) Domoic acid is a potent neurotoxin to neonatal rats. Nat. Toxins 5 (2), 74 - 79.

    Article  PubMed  CAS  Google Scholar 

  29. Scholin, C., Massion, G., Mellinger, E., Brown, M., Wright, D., and Cline, D. (1999) The development and application of molecular probes and novel instrumentation for detection of harmful algae. Ocean Community Conference 98 Proceedings, Marine Technology Society, Washington, DC, vol. 1, pp. 367 - 370.

    Google Scholar 

  30. Trainer, V. L. and Baden, D. G. (1999) High affinity binding of red tide neurotoxins to marine mammal brain. Aquat. Toxicol. 46, 139 - 148.

    Article  CAS  Google Scholar 

  31. AOAC (1984). Official Methods of Analysis of the Association of Official Analytical Chemists (Williams, S., ed.), 14th ed. Association of Official Analytical Chemists, Secs 18.086-18. 092, AOAC Inc., Arlington, VA, pp. 344 - 345.

    Google Scholar 

  32. Ridgway, S. H., McCormick, J. G., and Weyer, E. G. (1974) Surgical approach to the dolphin’s ear. J. Exp. Zool. 188 (3), 265 - 276.

    Article  PubMed  CAS  Google Scholar 

  33. McFarren, E. F., Schafer, M. L., Campbell, J. E., Lewis, K. H., Jensen, E. T., and Schantz, E. J. (1960) Public health significance of paralytic shellfish poison. Adv. Food Res. 10, 135 - 179.

    Article  PubMed  CAS  Google Scholar 

  34. Ridgway, S. H. (1972) Homeostasis in the aquatic environment, in Mammals of the Sea: Biology and Medicine ( Ridgeway, S. H., ed.), Thomas, Springfield, IL, pp. 590 - 603.

    Google Scholar 

  35. Perl, T. M., Bedard, L., Kosatsky, T., Hocking, J. C., Todd, E. C. and Remis, R. C. (1990) An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. N. Engl. J. Med. 322, 1775 - 1780.

    Article  PubMed  CAS  Google Scholar 

  36. Landsberg, J. H. (1996) Neoplasia and biotoxins in bivalves: is there a connection? J. Shellfish Res. 15, 203 - 230.

    Google Scholar 

  37. Trainer, V. L., McPhee, J. C., Boutelet-Bochan, H., Baker, C., Scheuer, T., Babin, D., et al. (1997) High affinity binding of pyrethroids to the alpha subunit of brain sodium channels. Mol. Pharmacol. 51, 651 - 657.

    Google Scholar 

  38. Wekell, J. C., Gauglitz, Jr., E. J., Barnett, H. J., Hatfield, C. L., and Eklund, M. (1994) The occurrence of domoic acid in razor clams (Siliqua patula), Dungeness crab (Cancer magister), and anchovies (Engraulis mordax). J. Shellfish Res. 13, 587 - 593.

    Google Scholar 

  39. Garthwaite, I., Ross, K. M., Miles, C. O., Hansen, R. P., Foster, D., Wilkins, A. L., and Towers, N. R. (1998) Polyclonal antibodies to domoic acid, and their use in immunoassays for domoic acid in sea water and shellfish. Nat. Toxins 6, 93 - 104.

    Google Scholar 

  40. Fairey, E., Stuart, N., Busman, M., Kimm-Brinson, D., Moeller, P., and Ramsdell, J. (2001) Biomonitoring brevetoxin exposure in mammals using blood spot cards, in Harmful Algal Blooms (Hallegraeff, G., ed.), 9th International Conference Proceedings.

    Google Scholar 

  41. Baden, D. G., Abraham, W., Fleming, L., Bossart, G., Benson, J. and Cheng, Y. S. (2001) What is the respiratory irritant in the air during Florida red tides? in Harmful Algal Blooms (Hallegraeff, G., ed.), 9th International Conference Proceedings.

    Google Scholar 

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Trainer, V.L. (2002). Marine Mammals as Sentinels of Environmental Biotoxins. In: Massaro, E.J. (eds) Handbook of Neurotoxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-132-9_18

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  • DOI: https://doi.org/10.1007/978-1-59259-132-9_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-193-6

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