Manganese in Health and Disease

From Transport to Neurotoxicity
  • Michael Aschner
  • James R. Connor
  • David C. Dorman
  • Elise A. Malecki
  • Kent E. Vrana


Manganese (Mn) is a mineral that is required in small amounts to manufacture enzymes necessary for the metabolism of proteins and fats. A partial list of Mn-dependent enzyme families includes oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. Mn is involved in the function of numerous organ systems and is needed for normal immune function, regulation of blood sugars, production of cellular energy, reproduction, digestion, and bone growth. Mn works with vitamin K to support clotting of the blood. As a vital component of superoxide dismutase (SOD), Mn has important antioxidant properties since MnSOD is one of the body’s main frontline defense mechanisms against damaging free radicals.


Choroid Plexus Inhalation Exposure Methylcyclopentadienyl Manganese Tricarbonyl Manganese Neurotoxicity Methylcyclopentadienyl Manganese Tricarbonyl 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Michael Aschner
  • James R. Connor
  • David C. Dorman
  • Elise A. Malecki
  • Kent E. Vrana

There are no affiliations available

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