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Early Studies of Thrombolytic Therapy for Stroke

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Thrombolytic Therapy for Stroke

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Abstract

The demonstration that t-PA is clinically effective for acute ischemic stroke treated within three hours of symptom onset was based upon many important studies over the past two decades that then lead to groundbreaking preliminary clinical trials (1–3). This chapter will highlight and discuss this historical aspect of investigations and their results so as to place the current state-of-the-art in perspective. Thrombolytic therapy is an inherently attractive treatment for ischemic stroke based on the known pathologic and angiographic substrates of ischemic cerebrovascular disease. The majority of acute ischemic strokes are the direct consequences of atherothrombosis or thromboembolism of a cerebral or Precerbral artery (see Chapter 2) (4–6). The critical event is usually the formation of an acute thrombus (6). The basis for thrombolytic treatment is to achieve arterial recanalization with a relatively safe agent soon enough to improve patient outcome.

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Authors
  1. Anne M. Guyot MD
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  2. Luchi Quinones MD
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  3. Steven R. Levine MD
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  1. UCSD Stroke Center, San Diego, CA, USA

    Patrick D. Lyden MD

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Guyot, A.M., Quinones, L., Levine, S.R. (2001). Early Studies of Thrombolytic Therapy for Stroke. In: Lyden, P.D. (eds) Thrombolytic Therapy for Stroke. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-131-2_6

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