The Proteome

  • Daniel C. Liebler


Each of our cells contains all the information necessary to make a complete human being. However, not all the genes are expressed in all the cells. Genes that code for enzymes essential to basic cellular functions (e.g., glucose catabolism, DNA synthesis) are expressed in virtually all cells, whereas those with highly specialized functions are expressed only in specific cell types (e.g., rhodopsin in retinal pigment epithelium). Thus, all cells express: 1) genes whose protein products provide essential functions, and 2) genes whose protein products provide unique cell-specific functions. Thus, every organism has one genome, but many proteomes.


Retinal Pigment Epithelium Codon Bias Glucose Catabolism Cysteine Thiol Basic Cellular Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Suggested Reading

  1. Apweiler, R., Attwood, T. K., Bairoch, A., Bateman, A., Birney, E., et al. (2001) The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res. 29, 37–40.PubMedCrossRefGoogle Scholar
  2. Coghlan, A. and Wolfe, K. H. (2000) Relationship of codon bias to mRNA concentration and protein length in Saccharomyces cerevisiae. Yeast 16, 1131–1145.PubMedCrossRefGoogle Scholar
  3. Gygi, S. P., Rochon, Y., Franza, B. R., and Aebersold, R. (1999) Correlation between protein and mRNA abundance in yeast. Mol. Cell Biol. 19, 1720–1730.PubMedGoogle Scholar
  4. Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor Miklos, G. L., Nelson, C. R., et al. (2000) Comparative genomics of the eukaryotes. Science 287, 2204–2215.PubMedCrossRefGoogle Scholar
  5. Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., et al. (2001) The sequence of the human genome. Science 291, 1304–1351.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Daniel C. Liebler
    • 1
  1. 1.College of PharmacyThe University of ArizonaTucsonUSA

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