SALSA: An Algorithm for Mining Specific Features of Tandem MS Data
We know that our sample contains many proteins, but we only wish to identify those that bear some specific modification. This could be a posttranslational modification, such as phosphorylation, or a modification by a drug or other chemical.
We want to identify peptides in a mixture that all share some sequence identity, but may differ in other ways. This could be due to the presence of wild-type and mutant forms of a protein.
We know or suspect that our sample contains a particular protein, but we also suspect that it may be present in multiple modified forms and we wish to detect all of them.
KeywordsNeutral Loss Neutral Fragment Residue Mass Stable Amino Acid Virtual Ruler
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- Liebler, D. C., Hansen, B. T., Davey, S. W., Tiscareno, L., and Mason, D. E. (2001) Peptide sequence motif analysis of tandem ms data with the SALSA algorithm. Anal. Chem., in press.Google Scholar