Abstract
Tumor necrosis factor-α (TNF-α) has been shown to induce hemorrhagic necrosis and regression in experimental murine solid tumors (1). When infused into mice bearing methylcholanthrene-A-induced (MethA) fibrosarcomas, there is rapid induction of intravascular coagulation at the tumor site resulting in a major drop in tumor blood flow (2). In this model, intravascular coagulation is initiated by enhanced expression of tissue factor (or thromboplastin) on the luminal surface of the tumor-associated endothelial cells, ultimately leading to the deposition of insoluble fibrin on the endothelial surface (2,3). It has been hypothesized that this excessive thrombus formation leads to vascular occlusion, precipitating tumor cell death and regression of the tumor.
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Murray, C., Tas, M. (2002). Endothelial Monocyte-Activating Polypeptide II. In: Fan, TP.D., Kohn, E.C. (eds) The New Angiotherapy. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-126-8_25
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DOI: https://doi.org/10.1007/978-1-59259-126-8_25
Publisher Name: Humana Press, Totowa, NJ
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Online ISBN: 978-1-59259-126-8
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