Abstract
The spleen is a uniquely adapted lymphoid organ that is dedicated to the clearance of blood cells, microorganisms, and other particles from the blood. This chapter deals with the microanatomy of the spleen, its highly specialized extracellular matrix components, distinctive vascular endothelial cell receptors, and the extraordinary organization of the venous vasculature. We also address the cellular mechanisms of splenic clearance, which are typified by the vascular organization of the spleen; mechanisms and regulation of clearance, and the development of a unique component; specialized barrier cells, which may be essential to the spleen’s clearance functions in stress.
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References
Blue, J. and Weiss, L. (1981a) Periarterial macrophage sheaths (ellipsoids) in cat spleen: an electron microscope study. Am. J. Anat. 161, 115–134.
Blue, J. and Weiss, L. (1981b) Electron microscopy of the red pulp of the dog spleen including vascular arrangements, perarterial macrophage sheaths (ellipsoids) and the contractile innervated reticular meshwork. Am. J. Anat. 161, 189–281.
Borrello, M. A. and Phipps, R. P. (1996) Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsets. Cell. Immunol. 173, 198–206.
Buckley, P. J., Smith, M. R., Braverman, M. F., and Dickson, S. A. (1987) Human spleen contains phenotypic subsets of macrophage and dendritic cells that occupy discrete microanatomic locations. Am. J. Pathol. 128, 505–520.
Drenckhahn, D. and Wagner, J. (1986) Stress fibers in the splenic sinus endothelium in situ: molecular structure, relationship to the extracellular matrix and contractility. J. Cell Biol. 102, 1738–1747.
Faller, A. (1985) Splenic architecture as reflected in the connective tissue structure of the human spleen. Experientia 41, 164–167.
Ford, W. L. (1969) Immunological and migratory properties of lymphocytes recirculating through the rat spleen. Br. J. Exp. Pathol. 50, 257–269.
Ford, W. L. (1968) The mechanism of lymphopenia produced by chronic irradiation of the rat spleen. Br. J. Exp. Pathol. 49, 502–513.
Fujita, T., Kashimura, M., and Adachi, K. (1982) Scanning electron microscopy studies of the spleen: normal and pathological. Scan. Electron Microsc. 1, 435–444.
Fujita, T., Kashimura, M., and Adachi, K. (1985) Scanning electron microscopy and terminal circulation. Experientia 41, 167–179.
Groom, A. C. (1987) Microcirculation of the spleen: new concepts, new challenges. Microvasc. Res. 34, 269–289.
Hammond, B. J. (1975) A compartimental analysis of circulatory lymphocytes in the spleen. Cell Tissue Kinet, 8, 153–169.
Kashimura, M. and Fujita, K. (1987) A scanning electron microscope study of human spleen: relationship between microcirculation and functions. Scan. Microsc. 1, 841–851.
Koike, R., Nishimura, T., Yasumizu, R., Tanaka, H., Hataba, Y., Hataba, Y., (1996) The splenic marginal zone is absent in alymphoplastic aly mutant mice. Eur. J. Immunol. 26, 669–675.
Kraal, G., Schornagel, K., Streeter, P. R., Holzmann, B., and Butcher, E. C. (1995) Expression of the mucosal vascular addressin, MadCAM1, on sinus-lining cells in the spleen. Am. J. Pathol. 147, 763–771.
Levesque, M. J. and Groom, A. C. (1981) Fast transit of red cells and plasma in contracted versus relaxed spleens. Can. J. Phys. Pharm. 59, 53–58.
Liakka, A., Apaja-Sarkkinen, M., Karttunen, T., and Autio-Harmainen, H. (1991) Distribution of laminin and types IV and III collagen in fetal, infant and adult human spleens. Cell Tissue Res. 263, 245–252.
Liakka, A. and Autio-Harmainen, H. (1992) Distribution of extracellular matrix proteins tenascin, fibronectin, and vitronectin in fetal, infant and adult human spleens. J. Histochem. Cytochem. 40, 1203–1210.
Liakka, A., Karjalainen, H., Virtanen, I., and Autio-Harmainen, H. (1995) Immuno-electron-microscopic localization of types III pN- collagen and IV collagen, laminin and tenascin in developing and adult human spleen. Cell Tissue Res. 282, 117–127.
Lyons, A. B. and Parish, C. R. (1995) Are murine marginal-zone macrophages the splenic white pulp analog of high endothelial venules? Eur. J. Immunol. 25, 3165–3172.
Pabst, R. (1988) The spleen in lymphocyte migration. Immunol. Today 9, 43–45.
Persson, S. G., Ekman, L., Lydin, G., and Tufvesson, G. (1973a) Circulatory effects of splenectomy in the horse. I. Effect on red cell distribution and variability of haematocrit in the peripheral blood. Zentralbl. Veterinarmed.[A] 20, 441–455.
Persson, S. G., Ekman, L., Lydin, G., and Tufvesson, G. (1973b) Circulatory effects of splenectomy in the horse. II. Effect of plasma volume and total and circulating red cell volume. Zentralbi. Veterinarmed.[A] 20, 456–468.
Reilly, F. D. (1985) Innervation and vascular pharmacodynamics of the mammalian spleen. Experientia 41, 187–192.
Reis, F. P. and Ferraz de Carvalho, C. A. (1988) Functional architecture of the splenic vein in the adult human. Acta. Anat. 132, 109–113.
Sasou, S., Satodate, R., Masuda, T., and Takayama, K. (1986) Scanning electron microscopic features of the spleen in the rat and human: a comparative study. Scan Electron Microsc. 3, 1063–1069.
Tablin, F. and Weiss, L. (1983) The equine spleen: an electron microscopic analysis. Am. J. Anat. 166, 393–416.
Toccanier-Pelte, M. F., Skalli, O., Kapanci, Y., and Gabbiani, G. (1987) Characterization of stromal cells with myoid features in lymph nodes and spleen in normal and pathologic conditions. Am. J. Pathol. 129, 109–118.
Uehara, K. and Miyoshi, M. (1997) Junctions between the sinus endothelial cells of rat spleen. Cell Tissue Res. 287, 187–192.
Van Ewijk, W. and Nieuwenhuis, P. (1985) Compartments, domains, and migration pathways of lymphoid cells in the splenic pulp. Experientia 41, 199–208.
van Krieken, J. H. J. M. and te Velde, J. (1988) Normal histology of the human spleen. Am. J. Surg. Pathol. 12 777–785.
Van Vliet, E., Melis, M., Foidart, J. M., and Van Ewijk, W. (1986) Reticular fibroblasts in peripheral lymphoid organs identified by a monoclonal antibody. J. Histochem. Cytochem. 34, 883–890.
Weiss, L. (1983) The red pulp of the spleen: structural basis of blood flow. Clin. Haematol. 12, 375–393.
Weiss, L. (1985) New trends in spleen research: conclusion. Experientia 41, 243–248.
Weiss, L., Powell, R., and Schiffman, F. J. (1985) Terminating arterial vessels in red pulp of the spleen. Experientia 40, 233–242.
Weiss, L., Geduldig, U., and Weidanz, W. (1986) Mechanisms of splenic control of murine malaria: reticular cell activation and the development of a blood-spleen barrier. Am. J. Anat. 176, 251–285.
Weiss, L. (1991) Barrier cells in the spleen. Immunol. Today 12, 24–29.
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Tablin, F., Chamberlain, J.K., Weiss, L. (2002). The Microanatomy of the Mammalian Spleen. In: Bowdler, A.J. (eds) The Complete Spleen. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-124-4_2
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DOI: https://doi.org/10.1007/978-1-59259-124-4_2
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61737-071-7
Online ISBN: 978-1-59259-124-4
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