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The Pathogenesis and Pathophysiology of Emphysema

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Lung Volume Reduction Surgery

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Abstract

Emphysema, the “abnormal permanent enlargement of the airspaces distal to the terminal bronchioles, accompanied by destruction of their walls and without obvious fibrosis,” is the result of a complex pathophysiologic process that occurs in the setting of one or more of several risk factors, of which by far the most important is cigarette smoking. Other risk factors for the development of emphysema include exposure to environmental tobacco smoke and/or high levels of ambient air pollution, sex, and race. Socioeconomic factors and occupational exposures may also contribute to or form part of the stimulus, which sets in motion the chain of events, which lead ultimately to destruction of lung tissue.

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Authors
  1. Neil W. Schluger MD
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  2. Jeanine D’Armiento MD
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Editors and Affiliations

  1. Division of Cardiothoracic Surgery, The New York Presbyterian Hospital-Columbia Presbyterian Center, New York, NY, USA

    Michael Argenziano MD (Columbia University College of Physicians and Surgeons) & Mark E. Ginsburg MD (Columbia University College of Physicians and Surgeons) (Columbia University College of Physicians and Surgeons) &  (Columbia University College of Physicians and Surgeons)

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© 2002 Springer Science+Business Media New York

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Schluger, N.W., D’Armiento, J. (2002). The Pathogenesis and Pathophysiology of Emphysema. In: Argenziano, M., Ginsburg, M.E. (eds) Lung Volume Reduction Surgery. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-121-3_1

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  • DOI: https://doi.org/10.1007/978-1-59259-121-3_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-220-9

  • Online ISBN: 978-1-59259-121-3

  • eBook Packages: Springer Book Archive

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