Serum and Urine Paraprotein Capillary Electrophoresis
Most requests for serum and urine electrophoresis occur because of the reversal of albumin/globulin ratios in the general chemistry profile or the presence of protein in the urine. The suspicion of possible myelomatosis by the physician also alerts him/her to rule out the presence of a monoclonal gammopathy in the serum or light chain in the urine. Because of the increased sensitivity afforded by the newer electrophoresis systems, paraproteins are found more often. Their appearance in a number of conditions exhibiting a B-cell lymphoproliferative response has renewed the interest of oncologists, hematologists, nephrologists, rheumatologists, internists, and neurologists.
KeywordsCapillary Electrophoresis Capillary Zone Electrophoresis Monoclonal Gammopathy Free Light Chain Sepharose Bead
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